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- W2593673372 abstract "Introduction Results from studies on awareness disorders in Alzheimer's disease (AD) are controversial because the methodologies, the “objects” of awareness, and the patients' pathologic stage all vary. Our study aimed to compare scores and correlates of awareness according to the stage of the disease and the assessment method. Methods We compared 20 mild AD patients to 20 mild cognitive impairment (MCI) patients, using the Patient Competency Rating Scale (PCRS; patient vs. caregiver report) and the Self-Consciousness Scale (rating scale). All patients underwent cognitive, psycho-affective and behavioral assessments (global cognition, executive functions, episodic memory, anxiety-depression, and apathy measures). Results Groups were matched for age, education, and gender. They were comparable on the depression, anxiety, apathy and awareness scales (ps > .05), and differed for all cognitive variables (p < .05). Using the median split approach, greater apathy and lower depression were associated with poorer awareness on the Self-Consciousness Scale (respectively: odds ratio [OR] = 4.8, p = .03; OR = 4.84, p = .04), and the PCRS (only apathy: OR = 9.3, p = .003). Greater apathy plus lower depression were associated with poorer awareness in both scales (PCRS: OR = 40.5, p = .005; Self-consciousness scale: OR = 28, p = .012). Conclusion These results evidence comparable awareness between AD and MCI patients. The correlates were more affective and behavioral than cognitive, independently from assessment method." @default.
- W2593673372 created "2017-03-16" @default.
- W2593673372 creator A5062355424 @default.
- W2593673372 date "2017-03-06" @default.
- W2593673372 modified "2023-09-27" @default.
- W2593673372 title "Awareness, apathy, and depression in Alzheimer's disease and mild cognitive impairment" @default.
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- W2593673372 doi "https://doi.org/10.1002/brb3.661" @default.
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