Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593687001> ?p ?o ?g. }
- W2593687001 abstract "Abstract The highly conserved eukaryotic WD40 repeat protein, Receptor for Activated C Kinase 1 (RACK1), is involved in the abscisic acid (ABA) response in Arabidopsis . However, the regulation of RACK1 and the proteins with which it interacts are poorly understood. Here, we show that RACK1B is sumoylated at four residues, Lys50, Lys276, Lys281 and Lys291. Sumoylation increases RACK1B stability and its tolerance to ubiquitination-mediated degradation in ABA response. As a result, sumoylation leads to enhanced interaction between RACK1B and RAP2.6, an AP2/ERF family transcription factor. RACK1B binds directly to the AP2 domain of RAP2.6, which alters the affinity of RAP2.6 for CE1 and GCC cis -acting regulatory elements. Taken together, our findings illustrate that protein stability controlled by dynamic post-transcriptional modification is a critical regulatory mechanism for RACK1B, which functions as scaffold protein for RAP2.6 in ABA signaling." @default.
- W2593687001 created "2017-03-16" @default.
- W2593687001 creator A5007655511 @default.
- W2593687001 creator A5062798207 @default.
- W2593687001 date "2017-03-08" @default.
- W2593687001 modified "2023-09-27" @default.
- W2593687001 title "Sumoylation stabilizes RACK1B and enhance its interaction with RAP2.6 in the abscisic acid response" @default.
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- W2593687001 doi "https://doi.org/10.1038/srep44090" @default.
- W2593687001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5341030" @default.
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