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- W2593691603 abstract "Abstract Identification of bioinspired yet nonnatural low cost and stable chemical scaffolds has been a long term goal for a plethora of applications, ranging from medicinal chemistry to material science. To meet the goal of biomimicry the use of peptoids has been one of the most symbolic approaches of the last two decades, due to their ability to adopt folded nanostructures, and thus be designed to adopt specific conformations. They have attracted significant attention as peptide and protein mimics due to their ability to circumvent complications associated with peptide therapeutics. Peptoids are oligomers based on a polyglycine backbone in which the side chains are appended to the amide nitrogen (poly- N -substituted glycines). This modification bestows protease resistance, while allowing suitable mimicry of the spacing between the critical chemical functionalities of bioactive peptides. Consequently, peptoids have found numerous applications in therapeutics, diagnostics, and biomedical applications. They are attractive targets for the drug discovery process because they can be amicably designed and developed as peptide mimics. Methods to direct the peptoid backbone toward formation of specific secondary structures, such as helices and also nanoparticles, have also been explored for the discovery of potent bioactive peptoid modules. So far, peptoids have established bioactivity as lung surfactants, small molecule drugs, drug delivery vehicles, cancer therapy and antimicrobial agents. In this chapter, we discuss the potential of peptoids in future therapeutics." @default.
- W2593691603 created "2017-03-16" @default.
- W2593691603 creator A5053657168 @default.
- W2593691603 creator A5058032023 @default.
- W2593691603 date "2017-01-01" @default.
- W2593691603 modified "2023-09-26" @default.
- W2593691603 title "Peptoids: tomorrow’s therapeutics" @default.
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