FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593695004> ?p ?o ?g. }

• W2593695004 endingPage "2365" @default.
• W2593695004 startingPage "2355" @default.
• W2593695004 abstract "Oral lichen planus (OLP) is a chronic inflammatory disease that may transform to oral squamous cell carcinoma (OSCC), while its carcinogenesis mechanisms are not entirely clear. This study was designed to identify the important genes involved in the malignant transformation of OLP to OSCC. After RNA-sequencing, the differently expressed genes (DEGs) in OLP vs. normal and OSCC vs. normal groups, respectively, were identified by limma package in R language, and then clustering analysis were conducted by Pheatmap package in R language. Weighed gene co-expression network analysis (WGCNA) was performed for the DEGs to screen disease-associated modules. Using Cytoscape software, co-expression networks were constructed for the genes involved in the modules. Enrichment analysis was conducted for the genes involved in the co-expression networks using GOstat package in R language. Finally, quantitative real-time PCR (qRT-PCR) experiments were conducted to validate the key genes. There were, respectively, 223 and 548 DEGs in OLP vs. normal and OSCC vs. normal groups. WGCNA identified the blue modules for the DEGs in the two groups as disease-associated modules. Moreover, 19 common DEGs (including upregulated BCL9L, PER2 and TSPAN33, and downregulated GMPS and HES1) associated with both OLP and OSCC were identified. In the co-expression networks, BCL9L, HES1, PER2 and TSPAN33 might function in OLP via interactions (such as BCL9L-TSPAN33 and HES1-PER2). qRT-PCR analysis showed that BCL9L, PER2 and TSPAN33 were significantly upregulated, and GMP and HES1 were downregulated. These findings indicated that BCL9L, GMPS, HES1, PER2 and TSPAN33 affected the transformation of OLP to OSCC." @default.
• W2593695004 created "2017-03-16" @default.
• W2593695004 creator A5002888527 @default.
• W2593695004 creator A5008633488 @default.
• W2593695004 creator A5017964156 @default.
• W2593695004 creator A5041178217 @default.
• W2593695004 creator A5041346764 @default.
• W2593695004 creator A5073501391 @default.
• W2593695004 creator A5075448316 @default.
• W2593695004 creator A5088677379 @default.
• W2593695004 date "2017-03-01" @default.
• W2593695004 modified "2023-09-29" @default.
• W2593695004 title "Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing" @default.
• W2593695004 cites W1528717512 @default.
• W2593695004 cites W1546952499 @default.
• W2593695004 cites W1561525288 @default.
• W2593695004 cites W1596104651 @default.
• W2593695004 cites W1630865570 @default.
• W2593695004 cites W1896312477 @default.
• W2593695004 cites W1968458420 @default.
• W2593695004 cites W1972749612 @default.
• W2593695004 cites W1973266395 @default.
• W2593695004 cites W1985437472 @default.
• W2593695004 cites W2006828798 @default.
• W2593695004 cites W2012129117 @default.
• W2593695004 cites W2021880506 @default.
• W2593695004 cites W2023860870 @default.
• W2593695004 cites W2029206815 @default.
• W2593695004 cites W2037027640 @default.
• W2593695004 cites W2048121577 @default.
• W2593695004 cites W2052233967 @default.
• W2593695004 cites W2053841715 @default.
• W2593695004 cites W2057498577 @default.
• W2593695004 cites W2070472499 @default.
• W2593695004 cites W2070519801 @default.
• W2593695004 cites W2073726927 @default.
• W2593695004 cites W2080818154 @default.
• W2593695004 cites W2081837126 @default.
• W2593695004 cites W2094500109 @default.
• W2593695004 cites W2099126202 @default.
• W2593695004 cites W2110675408 @default.
• W2593695004 cites W2111918987 @default.
• W2593695004 cites W2121182926 @default.
• W2593695004 cites W2122997780 @default.
• W2593695004 cites W2125951638 @default.
• W2593695004 cites W2128431594 @default.
• W2593695004 cites W2138255346 @default.
• W2593695004 cites W2140729960 @default.
• W2593695004 cites W2142019735 @default.
• W2593695004 cites W2143311031 @default.
• W2593695004 cites W2144078707 @default.
• W2593695004 cites W2146512944 @default.
• W2593695004 cites W2148654292 @default.
• W2593695004 cites W2151066442 @default.
• W2593695004 cites W2155142785 @default.
• W2593695004 cites W2156247618 @default.
• W2593695004 cites W2159015502 @default.
• W2593695004 cites W2163965551 @default.
• W2593695004 cites W2171232664 @default.
• W2593695004 cites W4300958603 @default.
• W2593695004 doi "https://doi.org/10.3892/or.2017.5487" @default.
• W2593695004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28259920" @default.
• W2593695004 hasPublicationYear "2017" @default.
• W2593695004 type Work @default.
• W2593695004 sameAs 2593695004 @default.
• W2593695004 citedByCount "19" @default.
• W2593695004 countsByYear W25936950042017 @default.
• W2593695004 countsByYear W25936950042018 @default.
• W2593695004 countsByYear W25936950042019 @default.
• W2593695004 countsByYear W25936950042020 @default.
• W2593695004 countsByYear W25936950042021 @default.
• W2593695004 countsByYear W25936950042022 @default.
• W2593695004 countsByYear W25936950042023 @default.
• W2593695004 crossrefType "journal-article" @default.
• W2593695004 hasAuthorship W2593695004A5002888527 @default.
• W2593695004 hasAuthorship W2593695004A5008633488 @default.
• W2593695004 hasAuthorship W2593695004A5017964156 @default.
• W2593695004 hasAuthorship W2593695004A5041178217 @default.
• W2593695004 hasAuthorship W2593695004A5041346764 @default.
• W2593695004 hasAuthorship W2593695004A5073501391 @default.
• W2593695004 hasAuthorship W2593695004A5075448316 @default.
• W2593695004 hasAuthorship W2593695004A5088677379 @default.
• W2593695004 hasBestOaLocation W25936950041 @default.
• W2593695004 hasConcept C104317684 @default.
• W2593695004 hasConcept C127561419 @default.
• W2593695004 hasConcept C2780283210 @default.
• W2593695004 hasConcept C2781018059 @default.
• W2593695004 hasConcept C29537977 @default.
• W2593695004 hasConcept C502942594 @default.
• W2593695004 hasConcept C54355233 @default.
• W2593695004 hasConcept C555283112 @default.
• W2593695004 hasConcept C70721500 @default.
• W2593695004 hasConcept C86803240 @default.
• W2593695004 hasConceptScore W2593695004C104317684 @default.
• W2593695004 hasConceptScore W2593695004C127561419 @default.
• W2593695004 hasConceptScore W2593695004C2780283210 @default.
• W2593695004 hasConceptScore W2593695004C2781018059 @default.
• W2593695004 hasConceptScore W2593695004C29537977 @default.

• next