FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593719294> ?p ?o ?g. }

• W2593719294 endingPage "1750002" @default.
• W2593719294 startingPage "1750002" @default.
• W2593719294 abstract "The cytochrome P450 (CYP) superfamily, exists in the human liver, is responsible for more than 90% of the metabolism of clinical drugs. So it is necessary to adopt a new kind of computer simulation methods that can predict the rejection capability of compounds for a concrete CYPs isoform. In this work, a model is presented for classification of CYP450 1A2 inhibitors and noninhibitors based on a multi-tiered deep belief network (DBN) on a large dataset. The dataset composed of more than 13,000 heterogeneous compounds was acquired from PubChem. Firstly, 139 2D and 53 3D descriptors are calculated and preprocessed. Then, the unsupervised learning method is used to train DBN model to automatically extract multiple levels of distributed representation from the descriptors of training set. Finally, by using testing set and external validation set, we evaluate the classified performance of DBN for the inhibition of CYP1A2. Meanwhile, the proposed model is compared with shallow machine learning models (support vector machine (SVM) and artificial neural network (ANN)). We also discussed the performance of DBN by comparing it with different features combination. The experimental results showed that DBN has a better prediction ability compared with SVM and ANN. And these models combined with the features of 2D and 3D obtain the best forecast accuracy." @default.
• W2593719294 created "2017-03-16" @default.
• W2593719294 creator A5027475930 @default.
• W2593719294 creator A5057774088 @default.
• W2593719294 creator A5075221279 @default.
• W2593719294 creator A5087361214 @default.
• W2593719294 creator A5088224258 @default.
• W2593719294 date "2017-03-01" @default.
• W2593719294 modified "2023-09-24" @default.
• W2593719294 title "Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors Based on Deep Belief Network" @default.
• W2593719294 cites W1586335931 @default.
• W2593719294 cites W1975448236 @default.
• W2593719294 cites W1990399577 @default.
• W2593719294 cites W2024059620 @default.
• W2593719294 cites W2031216614 @default.
• W2593719294 cites W2035278971 @default.
• W2593719294 cites W2045776044 @default.
• W2593719294 cites W2046589863 @default.
• W2593719294 cites W2060862064 @default.
• W2593719294 cites W2062202831 @default.
• W2593719294 cites W2065687591 @default.
• W2593719294 cites W2076461322 @default.
• W2593719294 cites W2077736710 @default.
• W2593719294 cites W2080355854 @default.
• W2593719294 cites W2100495367 @default.
• W2593719294 cites W2108069432 @default.
• W2593719294 cites W2108101947 @default.
• W2593719294 cites W2121732173 @default.
• W2593719294 cites W2136922672 @default.
• W2593719294 cites W2148804536 @default.
• W2593719294 cites W2233093977 @default.
• W2593719294 cites W2234529989 @default.
• W2593719294 cites W84368778 @default.
• W2593719294 cites W2066346983 @default.
• W2593719294 doi "https://doi.org/10.1142/s146902681750002x" @default.
• W2593719294 hasPublicationYear "2017" @default.
• W2593719294 type Work @default.
• W2593719294 sameAs 2593719294 @default.
• W2593719294 citedByCount "6" @default.
• W2593719294 countsByYear W25937192942018 @default.
• W2593719294 countsByYear W25937192942020 @default.
• W2593719294 countsByYear W25937192942021 @default.
• W2593719294 countsByYear W25937192942022 @default.
• W2593719294 crossrefType "journal-article" @default.
• W2593719294 hasAuthorship W2593719294A5027475930 @default.
• W2593719294 hasAuthorship W2593719294A5057774088 @default.
• W2593719294 hasAuthorship W2593719294A5075221279 @default.
• W2593719294 hasAuthorship W2593719294A5087361214 @default.
• W2593719294 hasAuthorship W2593719294A5088224258 @default.
• W2593719294 hasConcept C108583219 @default.
• W2593719294 hasConcept C119857082 @default.
• W2593719294 hasConcept C12267149 @default.
• W2593719294 hasConcept C134018914 @default.
• W2593719294 hasConcept C153180895 @default.
• W2593719294 hasConcept C154945302 @default.
• W2593719294 hasConcept C158180186 @default.
• W2593719294 hasConcept C177264268 @default.
• W2593719294 hasConcept C199360897 @default.
• W2593719294 hasConcept C41008148 @default.
• W2593719294 hasConcept C50644808 @default.
• W2593719294 hasConcept C526171541 @default.
• W2593719294 hasConcept C62231903 @default.
• W2593719294 hasConcept C70721500 @default.
• W2593719294 hasConcept C71924100 @default.
• W2593719294 hasConcept C86745063 @default.
• W2593719294 hasConcept C86803240 @default.
• W2593719294 hasConcept C97385483 @default.
• W2593719294 hasConceptScore W2593719294C108583219 @default.
• W2593719294 hasConceptScore W2593719294C119857082 @default.
• W2593719294 hasConceptScore W2593719294C12267149 @default.
• W2593719294 hasConceptScore W2593719294C134018914 @default.
• W2593719294 hasConceptScore W2593719294C153180895 @default.
• W2593719294 hasConceptScore W2593719294C154945302 @default.
• W2593719294 hasConceptScore W2593719294C158180186 @default.
• W2593719294 hasConceptScore W2593719294C177264268 @default.
• W2593719294 hasConceptScore W2593719294C199360897 @default.
• W2593719294 hasConceptScore W2593719294C41008148 @default.
• W2593719294 hasConceptScore W2593719294C50644808 @default.
• W2593719294 hasConceptScore W2593719294C526171541 @default.
• W2593719294 hasConceptScore W2593719294C62231903 @default.
• W2593719294 hasConceptScore W2593719294C70721500 @default.
• W2593719294 hasConceptScore W2593719294C71924100 @default.
• W2593719294 hasConceptScore W2593719294C86745063 @default.
• W2593719294 hasConceptScore W2593719294C86803240 @default.
• W2593719294 hasConceptScore W2593719294C97385483 @default.
• W2593719294 hasIssue "01" @default.
• W2593719294 hasLocation W25937192941 @default.
• W2593719294 hasOpenAccess W2593719294 @default.
• W2593719294 hasPrimaryLocation W25937192941 @default.
• W2593719294 hasRelatedWork W2567271240 @default.
• W2593719294 hasRelatedWork W2741836081 @default.
• W2593719294 hasRelatedWork W2803710604 @default.
• W2593719294 hasRelatedWork W2919358988 @default.
• W2593719294 hasRelatedWork W2991591812 @default.
• W2593719294 hasRelatedWork W3082895349 @default.
• W2593719294 hasRelatedWork W3123344745 @default.
• W2593719294 hasRelatedWork W3136979370 @default.
• W2593719294 hasRelatedWork W3196183652 @default.

• next