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- W2593744497 abstract "Mitochondria are major producers of reactive oxygen species (ROS) in many cells including cancer cells. However, complex interrelationships between mitochondrial ROS (mitoROS), mitochondrial membrane potential (ΔΨm) and Ca2+ are not completely understood. Using human carcinoma cells, we further highlight biphasic ROS dynamics: - gradual mitoROS increase followed by mitoROS flash. Also, we demonstrate heterogeneity in rates of mitoROS generation and flash initiation time. Comparing mitochondrial and near-extra-mitochondrial signals, we show that mechanisms of mitoROS flashes in single mitochondria, linked to mitochondrial permeability transition pore opening (ΔΨm collapse) and calcium sparks, may involve flash triggering by certain levels of external ROS released from the same mitochondria. In addition, mitochondria-mitochondria interactions can produce wave propagations of mitoROS flashes and ΔΨm collapses in cancer cells similar to phenomena of ROS-induced ROS release (RIRR). Our data suggest that in cancer cells RIRR, activation of mitoROS flashes and mitochondrial depolarization may involve participation of extramitochondrial-ROS produced either by individual mitochondria and/or by neighboring mitochondria. This could represent general mechanisms in ROS-ROS signaling with suggested role in both mitochondrial and cellular physiology and signaling." @default.
- W2593744497 created "2017-03-16" @default.
- W2593744497 creator A5002203819 @default.
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- W2593744497 date "2017-06-01" @default.
- W2593744497 modified "2023-10-16" @default.
- W2593744497 title "Synchronism in mitochondrial ROS flashes, membrane depolarization and calcium sparks in human carcinoma cells" @default.
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- W2593744497 doi "https://doi.org/10.1016/j.bbabio.2017.03.001" @default.
- W2593744497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5972832" @default.
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