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• W2593756477 endingPage "1189" @default.
• W2593756477 startingPage "1177" @default.
• W2593756477 abstract "Rutin intake is associated with a reduced risk of cardiovascular disease (CVD). The exact mechanism by which rutin can protect against CVD development is still enigmatic. Since, rutin is a compound with a relatively short half-life, the direct antioxidant effect of rutin cannot explain the long-lasting effect on human health. We hypothesized that rutin next to its direct antioxidant effect that improves endothelial function, may also induce an adaptive response in endogenous antioxidant systems.In Human Umbilical Vein Endothelial Cells (HUVECs), the direct antioxidant effect was confirmed. During scavenging of Reactive Oxygen Species (ROS), rutin is oxidized into a quinone derivative. HUVECs pretreated with rutin quinone became better protected against a second challenge with oxidative stress 3h later. LC-MS/MS analysis indicated that rutin quinone targets cysteine 151 of Keap1. Moreover, we found that the quinone is an inhibitor of the selenoprotein thioredoxin reductase 1. These properties correlated with an activation of Nrf2 and upregulation of Glutamate Cysteine Ligase, the rate-limiting enzyme of glutathione synthesis, while NF-κB and HIF activation became blunted by rutin treatment. Furthermore, rutin was found to prevent hydrogen peroxide from impairing relaxation of human chorionic plate placental vessels, which may help to protect endothelial function.Rutin functions as an antioxidant and is oxidized into a quinone that upregulates the Nrf2-mediated endogenous antioxidant response. This mechanism suggests that rutin selectively exerts its protective effects in regions with increased oxidative stress, and explains how rutin reduces the risk of developing CVD.The newly found mechanism behind the long-term protection of rutin against cardiovascular disease, the selective upregulation of endogenous antioxidant systems, contributes to the further understanding why rutin can reduce the risk on developing cardiovascular disease." @default.
• W2593756477 created "2017-03-16" @default.
• W2593756477 creator A5005254219 @default.
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• W2593756477 date "2017-05-01" @default.
• W2593756477 modified "2023-10-01" @default.
• W2593756477 title "Rutin protects against H 2 O 2 -triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress" @default.
• W2593756477 cites W1491000488 @default.
• W2593756477 cites W1499399870 @default.
• W2593756477 cites W1507486876 @default.
• W2593756477 cites W1547863599 @default.
• W2593756477 cites W1580210576 @default.
• W2593756477 cites W1785455093 @default.
• W2593756477 cites W1802175835 @default.
• W2593756477 cites W1910630333 @default.
• W2593756477 cites W1914622032 @default.
• W2593756477 cites W1964994058 @default.
• W2593756477 cites W1966222851 @default.
• W2593756477 cites W1967291007 @default.
• W2593756477 cites W1970161481 @default.
• W2593756477 cites W1975529273 @default.
• W2593756477 cites W1979289204 @default.
• W2593756477 cites W1979780112 @default.
• W2593756477 cites W1980539789 @default.
• W2593756477 cites W1981354055 @default.
• W2593756477 cites W1982754643 @default.
• W2593756477 cites W1983900858 @default.
• W2593756477 cites W1984363621 @default.
• W2593756477 cites W1984556646 @default.
• W2593756477 cites W1992628540 @default.
• W2593756477 cites W1996385661 @default.
• W2593756477 cites W1997684038 @default.
• W2593756477 cites W2001338914 @default.
• W2593756477 cites W2004992052 @default.
• W2593756477 cites W2008344420 @default.
• W2593756477 cites W2008735943 @default.
• W2593756477 cites W2011189284 @default.
• W2593756477 cites W2013158621 @default.
• W2593756477 cites W2015529197 @default.
• W2593756477 cites W2018475044 @default.
• W2593756477 cites W2024263079 @default.
• W2593756477 cites W2026789068 @default.
• W2593756477 cites W2030518813 @default.
• W2593756477 cites W2030691662 @default.
• W2593756477 cites W2032832927 @default.
• W2593756477 cites W2034357128 @default.
• W2593756477 cites W2039705486 @default.
• W2593756477 cites W2043520637 @default.
• W2593756477 cites W2047054612 @default.
• W2593756477 cites W2053086158 @default.
• W2593756477 cites W2053310956 @default.
• W2593756477 cites W2053567988 @default.
• W2593756477 cites W2055421073 @default.
• W2593756477 cites W2056242053 @default.
• W2593756477 cites W2057396623 @default.
• W2593756477 cites W2057792543 @default.
• W2593756477 cites W2060020300 @default.
• W2593756477 cites W2060084080 @default.
• W2593756477 cites W2060273477 @default.
• W2593756477 cites W2066241876 @default.
• W2593756477 cites W2066472053 @default.
• W2593756477 cites W2066757676 @default.
• W2593756477 cites W2075976974 @default.
• W2593756477 cites W2081390089 @default.
• W2593756477 cites W2082407778 @default.
• W2593756477 cites W2083904981 @default.
• W2593756477 cites W2086882156 @default.
• W2593756477 cites W2088548720 @default.
• W2593756477 cites W2097702728 @default.
• W2593756477 cites W2105238585 @default.
• W2593756477 cites W2106303873 @default.
• W2593756477 cites W2107277218 @default.
• W2593756477 cites W2115487906 @default.
• W2593756477 cites W2119293458 @default.
• W2593756477 cites W2123141519 @default.
• W2593756477 cites W2130029858 @default.
• W2593756477 cites W2132019871 @default.
• W2593756477 cites W2132961242 @default.
• W2593756477 cites W2134182910 @default.
• W2593756477 cites W2138228181 @default.
• W2593756477 cites W2138321862 @default.
• W2593756477 cites W2139923937 @default.
• W2593756477 cites W2144843569 @default.
• W2593756477 cites W2144862608 @default.
• W2593756477 cites W2145213768 @default.
• W2593756477 cites W2149023391 @default.
• W2593756477 cites W2150245854 @default.

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