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- W2593768764 startingPage "65" @default.
- W2593768764 abstract "Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been developed as antimalarial drug and is used worldwide. Interestingly, the bioactivity is not restricted to malaria treatment. We and others found that ARS-type drugs also reveal anticancer in vitro and in vivo. In this review, we give a systematic overview of the literature published over the past two decades until the end of 2016. Like other natural products, ARS acts in a multi-specific manner against tumors. The cellular response of ARS and its derivatives (dihydroartemisinin, artesunate, artemether, arteether) towards cancer cells include oxidative stress response by reactive oxygen species and nitric oxide, DNA damage and repair (base excision repair, homologous recombination, non-homologous end-joining), various cell death modes (apoptosis, autophagy, ferroptosis, necrosis, necroptosis, oncosis), inhibition of angiogenesis and tumor-related signal transduction pathways (e.g. Wnt/β-catenin pathway, AMPK pathway, metastatic pathways, and others) and signal transducers (NF-κB, MYC/MAX, AP-1, CREBP, mTOR etc). ARS-type drugs are at the stairways to the clinics. Several published case reports and pilot phase I/II trials indicate clinical anticancer activity of these compounds. Because of unexpected cases of hepatotoxicity, combinations of ARS-type drugs with complementary and alternative medicines are not recommended, until controlled clinical trials will prove the safety of non-approved combination treatments." @default.
- W2593768764 created "2017-03-16" @default.
- W2593768764 creator A5052981792 @default.
- W2593768764 date "2017-10-01" @default.
- W2593768764 modified "2023-10-11" @default.
- W2593768764 title "From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy" @default.
- W2593768764 cites W1156477804 @default.
- W2593768764 cites W1486901435 @default.
- W2593768764 cites W1513392008 @default.
- W2593768764 cites W1528480178 @default.
- W2593768764 cites W1547516899 @default.
- W2593768764 cites W1554600230 @default.
- W2593768764 cites W1579791519 @default.
- W2593768764 cites W1593692040 @default.
- W2593768764 cites W1913764854 @default.
- W2593768764 cites W1963914155 @default.
- W2593768764 cites W1964007315 @default.
- W2593768764 cites W1964470200 @default.
- W2593768764 cites W1965003536 @default.
- W2593768764 cites W1966091165 @default.
- W2593768764 cites W1966533879 @default.
- W2593768764 cites W1967509253 @default.
- W2593768764 cites W1967596683 @default.
- W2593768764 cites W1968570263 @default.
- W2593768764 cites W1969451624 @default.
- W2593768764 cites W1970370517 @default.
- W2593768764 cites W1970605250 @default.
- W2593768764 cites W1970930356 @default.
- W2593768764 cites W1971470458 @default.
- W2593768764 cites W1972596256 @default.
- W2593768764 cites W1973840375 @default.
- W2593768764 cites W1975195678 @default.
- W2593768764 cites W1976407590 @default.
- W2593768764 cites W1976605766 @default.
- W2593768764 cites W1976940878 @default.
- W2593768764 cites W1978757362 @default.
- W2593768764 cites W1981838111 @default.
- W2593768764 cites W1981953479 @default.
- W2593768764 cites W1982754259 @default.
- W2593768764 cites W1983356712 @default.
- W2593768764 cites W1984208355 @default.
- W2593768764 cites W1984901124 @default.
- W2593768764 cites W1985323404 @default.
- W2593768764 cites W1985976931 @default.
- W2593768764 cites W1986256291 @default.
- W2593768764 cites W1987407107 @default.
- W2593768764 cites W1987754149 @default.
- W2593768764 cites W1990285247 @default.
- W2593768764 cites W1990312495 @default.
- W2593768764 cites W1991637026 @default.
- W2593768764 cites W1992862362 @default.
- W2593768764 cites W1993494844 @default.
- W2593768764 cites W1994416116 @default.
- W2593768764 cites W1995521183 @default.
- W2593768764 cites W1995685700 @default.
- W2593768764 cites W1996106658 @default.
- W2593768764 cites W1996693184 @default.
- W2593768764 cites W1997183854 @default.
- W2593768764 cites W2001556950 @default.
- W2593768764 cites W2002694981 @default.
- W2593768764 cites W2003368406 @default.
- W2593768764 cites W2004863151 @default.
- W2593768764 cites W2005944513 @default.
- W2593768764 cites W2008290036 @default.
- W2593768764 cites W2009153962 @default.
- W2593768764 cites W2013090067 @default.
- W2593768764 cites W2013299486 @default.
- W2593768764 cites W2014072357 @default.
- W2593768764 cites W2014676459 @default.
- W2593768764 cites W2015301828 @default.
- W2593768764 cites W2015523279 @default.
- W2593768764 cites W2015726039 @default.
- W2593768764 cites W2015924428 @default.
- W2593768764 cites W2016486460 @default.
- W2593768764 cites W2017297090 @default.
- W2593768764 cites W2017640872 @default.
- W2593768764 cites W2018053695 @default.
- W2593768764 cites W2018544899 @default.
- W2593768764 cites W2019647403 @default.
- W2593768764 cites W2019748072 @default.
- W2593768764 cites W2022114614 @default.
- W2593768764 cites W2022462894 @default.
- W2593768764 cites W2023405265 @default.
- W2593768764 cites W2023972534 @default.
- W2593768764 cites W2024050143 @default.
- W2593768764 cites W2024217069 @default.
- W2593768764 cites W2026556401 @default.
- W2593768764 cites W2027240524 @default.
- W2593768764 cites W2029985793 @default.
- W2593768764 cites W2032576041 @default.
- W2593768764 cites W2032680197 @default.
- W2593768764 cites W2033721665 @default.
- W2593768764 cites W2033992955 @default.
- W2593768764 cites W2034173969 @default.
- W2593768764 cites W2034518537 @default.
- W2593768764 cites W2035152288 @default.
- W2593768764 cites W2035228001 @default.
- W2593768764 cites W2035802567 @default.