FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593823651> ?p ?o ?g. }

• W2593823651 endingPage "796" @default.
• W2593823651 startingPage "789" @default.
• W2593823651 abstract "Depressive disorders cause large socioeconomic effects influencing not only the patients themselves but also their family and broader community as well. To better understand the physiologic factors underlying depression, in this study, we performed metabolomics analysis, an omics technique that comprehensively analyzes small molecule metabolites in biological samples. Specifically, we utilized high-resolution magic-angle spinning-1H-NMR (HRMAS-1H-NMR) spectroscopy to comprehensively analyze the changes in metabolites in the hippocampal tissue of rats exposed to chronic stress (CS) via multi-step principal component analysis (multi-step PCA). The rats subjected to CS exhibited obvious depression-like behaviors. High correlations were observed between the first principal component (PC1) score in the score plot obtained using multi-step PCA and measurements from depression-like behavioral testing (body weight, sucrose preference test, and open field test). Alanine, glutamate, glutamine, and aspartate levels in the hippocampal tissue were significantly lower, whereas N-acetylaspartate, myo-inositol, and creatine were significantly higher in the CS group compared to the control (non-CS) group. As alanine, glutamate, and glutamine are known to be involved in energy metabolism, especially in the tricarboxylic acid cycle, chronic exogenous stress may have induced abnormalities in energy metabolism in the brains of the rats. The results suggest that N-acetylaspartate and creatine levels may have increased in order to complement the loss of energy-producing activity resulting from the development of the depression-like disorder. Multi-step PCA therefore allowed an exploration of the degree of depression-like symptoms as represented by changes in intrinsic metabolites." @default.
• W2593823651 created "2017-03-16" @default.
• W2593823651 creator A5012309946 @default.
• W2593823651 creator A5020054422 @default.
• W2593823651 creator A5039442610 @default.
• W2593823651 creator A5040346157 @default.
• W2593823651 creator A5058152187 @default.
• W2593823651 creator A5066805489 @default.
• W2593823651 creator A5073198239 @default.
• W2593823651 date "2017-01-01" @default.
• W2593823651 modified "2023-10-16" @default.
• W2593823651 title "High-Resolution Magic-Angle Spinning-¹H-NMR Spectroscopy-Based Metabolic Profiling of Hippocampal Tissue in Rats with Depression-Like Symptoms" @default.
• W2593823651 cites W1963823771 @default.
• W2593823651 cites W1980053634 @default.
• W2593823651 cites W1981825819 @default.
• W2593823651 cites W1997017221 @default.
• W2593823651 cites W2008391268 @default.
• W2593823651 cites W2017014565 @default.
• W2593823651 cites W2019686079 @default.
• W2593823651 cites W2021431498 @default.
• W2593823651 cites W2025616795 @default.
• W2593823651 cites W2027098744 @default.
• W2593823651 cites W2036992368 @default.
• W2593823651 cites W2044505607 @default.
• W2593823651 cites W2046800442 @default.
• W2593823651 cites W2048696229 @default.
• W2593823651 cites W2052924277 @default.
• W2593823651 cites W2053265328 @default.
• W2593823651 cites W2053585277 @default.
• W2593823651 cites W2062099857 @default.
• W2593823651 cites W2069289521 @default.
• W2593823651 cites W2073636547 @default.
• W2593823651 cites W2074504157 @default.
• W2593823651 cites W2088818024 @default.
• W2593823651 cites W2092581653 @default.
• W2593823651 cites W2098539376 @default.
• W2593823651 cites W2128782976 @default.
• W2593823651 cites W2150116418 @default.
• W2593823651 cites W2152699744 @default.
• W2593823651 cites W2325189010 @default.
• W2593823651 cites W2331058183 @default.
• W2593823651 cites W2334787351 @default.
• W2593823651 cites W2417887391 @default.
• W2593823651 cites W2950416655 @default.
• W2593823651 doi "https://doi.org/10.1248/bpb.b16-00783" @default.
• W2593823651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28260722" @default.
• W2593823651 hasPublicationYear "2017" @default.
• W2593823651 type Work @default.
• W2593823651 sameAs 2593823651 @default.
• W2593823651 citedByCount "13" @default.
• W2593823651 countsByYear W25938236512018 @default.
• W2593823651 countsByYear W25938236512019 @default.
• W2593823651 countsByYear W25938236512020 @default.
• W2593823651 countsByYear W25938236512021 @default.
• W2593823651 countsByYear W25938236512022 @default.
• W2593823651 crossrefType "journal-article" @default.
• W2593823651 hasAuthorship W2593823651A5012309946 @default.
• W2593823651 hasAuthorship W2593823651A5020054422 @default.
• W2593823651 hasAuthorship W2593823651A5039442610 @default.
• W2593823651 hasAuthorship W2593823651A5040346157 @default.
• W2593823651 hasAuthorship W2593823651A5058152187 @default.
• W2593823651 hasAuthorship W2593823651A5066805489 @default.
• W2593823651 hasAuthorship W2593823651A5073198239 @default.
• W2593823651 hasBestOaLocation W25938236511 @default.
• W2593823651 hasConcept C103191249 @default.
• W2593823651 hasConcept C126322002 @default.
• W2593823651 hasConcept C126838900 @default.
• W2593823651 hasConcept C134018914 @default.
• W2593823651 hasConcept C136569192 @default.
• W2593823651 hasConcept C143409427 @default.
• W2593823651 hasConcept C148762608 @default.
• W2593823651 hasConcept C170493617 @default.
• W2593823651 hasConcept C185592680 @default.
• W2593823651 hasConcept C21565614 @default.
• W2593823651 hasConcept C2779177272 @default.
• W2593823651 hasConcept C2779349466 @default.
• W2593823651 hasConcept C2779896295 @default.
• W2593823651 hasConcept C2781161787 @default.
• W2593823651 hasConcept C43617362 @default.
• W2593823651 hasConcept C515207424 @default.
• W2593823651 hasConcept C55493867 @default.
• W2593823651 hasConcept C61174792 @default.
• W2593823651 hasConcept C66974803 @default.
• W2593823651 hasConcept C71240020 @default.
• W2593823651 hasConcept C71924100 @default.
• W2593823651 hasConcept C84935128 @default.
• W2593823651 hasConceptScore W2593823651C103191249 @default.
• W2593823651 hasConceptScore W2593823651C126322002 @default.
• W2593823651 hasConceptScore W2593823651C126838900 @default.
• W2593823651 hasConceptScore W2593823651C134018914 @default.
• W2593823651 hasConceptScore W2593823651C136569192 @default.
• W2593823651 hasConceptScore W2593823651C143409427 @default.
• W2593823651 hasConceptScore W2593823651C148762608 @default.
• W2593823651 hasConceptScore W2593823651C170493617 @default.
• W2593823651 hasConceptScore W2593823651C185592680 @default.
• W2593823651 hasConceptScore W2593823651C21565614 @default.
• W2593823651 hasConceptScore W2593823651C2779177272 @default.
• W2593823651 hasConceptScore W2593823651C2779349466 @default.

• next