Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593846306> ?p ?o ?g. }
- W2593846306 endingPage "38" @default.
- W2593846306 startingPage "25" @default.
- W2593846306 abstract "Febrile seizure (FS) is the most common seizure type in infants and young children. FS may induce functional changes in the hippocampal circuitries. Abnormality of excitatory and inhibitory neurotransmissions was previously related to wide-spread seizure attack in the hippocampus following recurrent seizure onset. To clarify the involvement of expressional changes and functional alterations of hippocampal interneurons with epileptogenesis following FS, we investigated long-term effects following recurrent seizure in a hyperthermia-induced seizure animal model. At 12 weeks following FS, the recurrent seizure time period, local field potentials (LFP) revealed high amplitude potential and a sharp wave characteristic of epilepsy. Mossy fiber reorganization in the hippocampus was also detected as abnormal synaptic connection at 8 weeks. Calretinin (CR) −positive interneurons were transiently enhanced during epileptogenic period at 7–9 weeks after FS in the CA1 and DG region and it is double labeled with VGLUT-1. However, although GABAA-α1 immunoreactivities were un-changed as similar to control hippocampus at 7–9 weeks after seizure onset, its expression was significantly enhanced at 4 weeks and 12 weeks and it is colocalized with GABA. Furthermore, the field excitatory postsynaptic potential (fEPSP) and the paired-pulse responses including population spike (PS) latency, excitability ratio and PS2/PS1 ratio were markedly altered in the CA1 and DG region at 12 weeks after FS. Therefore, our findings in present study indicate that these time-dependent changes may be based on the persistent alterations of hippocampal neuronal circuits in balance between excitatory and inhibitory responses, and may lead to the epileptogenesis and spread of seizure activity following FS." @default.
- W2593846306 created "2017-03-16" @default.
- W2593846306 creator A5004603769 @default.
- W2593846306 creator A5007523006 @default.
- W2593846306 creator A5010303370 @default.
- W2593846306 creator A5021769068 @default.
- W2593846306 creator A5027123155 @default.
- W2593846306 creator A5064580118 @default.
- W2593846306 date "2017-05-01" @default.
- W2593846306 modified "2023-10-17" @default.
- W2593846306 title "Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures" @default.
- W2593846306 cites W1482497049 @default.
- W2593846306 cites W1487386905 @default.
- W2593846306 cites W1503335897 @default.
- W2593846306 cites W1695332227 @default.
- W2593846306 cites W1842971324 @default.
- W2593846306 cites W1906116459 @default.
- W2593846306 cites W1942035355 @default.
- W2593846306 cites W1947066063 @default.
- W2593846306 cites W1964287283 @default.
- W2593846306 cites W1965013913 @default.
- W2593846306 cites W1965800877 @default.
- W2593846306 cites W1966135027 @default.
- W2593846306 cites W1969158362 @default.
- W2593846306 cites W1969480628 @default.
- W2593846306 cites W1969994771 @default.
- W2593846306 cites W1970843014 @default.
- W2593846306 cites W1973296281 @default.
- W2593846306 cites W1975730562 @default.
- W2593846306 cites W1975960101 @default.
- W2593846306 cites W1976072459 @default.
- W2593846306 cites W1976168790 @default.
- W2593846306 cites W1976437022 @default.
- W2593846306 cites W1976639286 @default.
- W2593846306 cites W1977040894 @default.
- W2593846306 cites W1977080405 @default.
- W2593846306 cites W1978488532 @default.
- W2593846306 cites W1978547106 @default.
- W2593846306 cites W1978722261 @default.
- W2593846306 cites W1981114447 @default.
- W2593846306 cites W1982867586 @default.
- W2593846306 cites W1982890379 @default.
- W2593846306 cites W1983665651 @default.
- W2593846306 cites W1984255188 @default.
- W2593846306 cites W1984710179 @default.
- W2593846306 cites W1985640395 @default.
- W2593846306 cites W1993507604 @default.
- W2593846306 cites W1995536650 @default.
- W2593846306 cites W1997059985 @default.
- W2593846306 cites W1999183559 @default.
- W2593846306 cites W2001323697 @default.
- W2593846306 cites W2005108511 @default.
- W2593846306 cites W2005887069 @default.
- W2593846306 cites W2007778040 @default.
- W2593846306 cites W2011818210 @default.
- W2593846306 cites W2013705793 @default.
- W2593846306 cites W2015610005 @default.
- W2593846306 cites W2018149936 @default.
- W2593846306 cites W2020064573 @default.
- W2593846306 cites W2021194790 @default.
- W2593846306 cites W2022998519 @default.
- W2593846306 cites W2023697740 @default.
- W2593846306 cites W2023871512 @default.
- W2593846306 cites W2025474716 @default.
- W2593846306 cites W2026916133 @default.
- W2593846306 cites W2030926288 @default.
- W2593846306 cites W2031622726 @default.
- W2593846306 cites W2035206318 @default.
- W2593846306 cites W2038202089 @default.
- W2593846306 cites W2038465691 @default.
- W2593846306 cites W2038913711 @default.
- W2593846306 cites W2044157568 @default.
- W2593846306 cites W2044894106 @default.
- W2593846306 cites W2045373812 @default.
- W2593846306 cites W2052381603 @default.
- W2593846306 cites W2054387717 @default.
- W2593846306 cites W2061742208 @default.
- W2593846306 cites W2062187642 @default.
- W2593846306 cites W2064696882 @default.
- W2593846306 cites W2065958702 @default.
- W2593846306 cites W2067071866 @default.
- W2593846306 cites W2070354822 @default.
- W2593846306 cites W2072648531 @default.
- W2593846306 cites W2073843946 @default.
- W2593846306 cites W2075062590 @default.
- W2593846306 cites W2077488853 @default.
- W2593846306 cites W2078394923 @default.
- W2593846306 cites W2078459395 @default.
- W2593846306 cites W2079302576 @default.
- W2593846306 cites W2081143235 @default.
- W2593846306 cites W2083577693 @default.
- W2593846306 cites W2085612514 @default.
- W2593846306 cites W2088804493 @default.
- W2593846306 cites W2089090377 @default.
- W2593846306 cites W2089553401 @default.
- W2593846306 cites W2092649925 @default.
- W2593846306 cites W2093428018 @default.
- W2593846306 cites W2102005912 @default.