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- W2593849573 abstract "A previous systematic review conducted in 2006 indicated that antidepressants may have the potential to improve the course of inflammatory bowel disease (IBD). The current study is an update of this review, aiming to identify and summarise available data on the effect of antidepressants on IBD activity published between 2006 and 2009. Electronic databases were searched to identify all relevant publications issued between 2006 and 2009 in English. Four studies met the inclusion criteria, three randomised controlled trials (RCTs) and one qualitative interview study. Six other papers with relevance to the subject that did not meet inclusion cirteria were also indentified. Desipramine was found to reduce vulnerability to colitis and to improve all examined inflammatory markers in the three animal RCTs, fluoxetine was found to protect against colitis in one RCT. Overall, the studies suggest a positive impact of antidepressants on inflammation in IBD. However, good-quality human data are lacking and more RCTs are needed." @default.
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- W2593849573 date "2009-01-01" @default.
- W2593849573 modified "2023-09-27" @default.
- W2593849573 title "Can antidepressants influence the course of inflammatory bowel disease? The current state of research" @default.
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