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• W2593904730 abstract "Mass spectrometry analysis combined with in vitro assays reveals that SPINDLY is an O-fucosyltransferase that modifies the growth repressor DELLA and consequently enhances its activity to regulate transcription of target genes. Plant development requires coordination among complex signaling networks to enhance the plant's adaptation to changing environments. DELLAs, transcription regulators originally identified as repressors of phytohormone gibberellin signaling, play a central role in integrating multiple signaling activities via direct protein interactions with key transcription factors. Here, we found that DELLA is mono-O-fucosylated by the novel O-fucosyltransferase SPINDLY (SPY) in Arabidopsis thaliana. O-fucosylation activates DELLA by promoting its interaction with key regulators in brassinosteroid- and light-signaling pathways, including BRASSINAZOLE-RESISTANT1 (BZR1), PHYTOCHROME-INTERACTING-FACTOR3 (PIF3) and PIF4. Moreover, spy mutants displayed elevated responses to gibberellin and brassinosteroid, and increased expression of common target genes of DELLAs, BZR1 and PIFs. Our study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development. This finding may have broader importance because SPY orthologs are conserved in prokaryotes and eukaryotes, thus suggesting that intracellular O-fucosylation may regulate a wide range of biological processes in diverse organisms." @default.
• W2593904730 created "2017-03-16" @default.
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• W2593904730 date "2017-02-28" @default.
• W2593904730 modified "2023-10-18" @default.
• W2593904730 title "The Arabidopsis O-fucosyltransferase SPINDLY activates nuclear growth repressor DELLA" @default.
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• W2593904730 doi "https://doi.org/10.1038/nchembio.2320" @default.
• W2593904730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5391292" @default.
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• W2593904730 hasPublicationYear "2017" @default.
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