Matches in SemOpenAlex for { <https://semopenalex.org/work/W2593965944> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2593965944 abstract "OBJECTIVE: To evaluate weakness and fatigue in a neuromuscular clinic patient population using the six-minute walk test (6MWT). BACKGROUND: The 6MWT is a primary end-point in many clinical trials involving neuromuscular disease. Weakness and fatigue are captured by the 6MWT, but it9s uncertain whether fatigue accompanies weakness in these conditions. Comparison across neuromuscular diseases has not been examined. DESIGN/METHODS: Sixty-seven patients performed the 6MWT: (SMA =19; DMD/BMD =23; myasthenia gravis (MG) =12; mitochondrial disease (MITO) =13), ranging in age from 5 to 45 years. SMA and DMD patients were tested longitudinally. Percent-predicted distance was computed from normative values to determine weakness. Fatigue was determined by the decrement in distance from the first to sixth minute. Pearson correlation coefficients examined the relationship between percent-predicted distance and fatigue. Paired sample t-tests evaluated fatigue and distance. RESULTS: Weakness was seen across all groups (%-predicted distance =62.2%). Fatigue was seen only in SMA (21.3% decrement), with other groups showing little or no fatigue (DMD/BMD =6.0%; MG =3.8%; MITO =0.7%). Correlation between %-predicted distance and fatigue was high only in SMA (R = - 0.73; p CONCLUSIONS: All patients with neuromuscular disease demonstrated weakness (%-predicted distance). Only the SMA group demonstrated fatigue, inversely related to walking ability. In contrast, weakness progressed in DMD without fatigue. Previous studies showed that functional worsening in SMA is absent over 12 months and only subtle over longer periods. Conversely, fatigue increased significantly over 12 months. These findings suggest independent mechanisms underlying weakness and fatigue in SMA. Supported by: SMA Foundation. Disclosure: Dr. Blumenschine has nothing to disclose. Dr. Montes has received personal compensation for activities with ISIS Pharmaceuticals, Inc. as a consultant. Dr. Dunaway has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Chiriboga has nothing to disclose. Dr. Sproule9s spouse holds stock and/or stock options in Pfizer Inc. Dr. De Vivo has received personal compensation for activities with Isis Pharmaceuticals." @default.
- W2593965944 created "2017-03-16" @default.
- W2593965944 creator A5002489918 @default.
- W2593965944 creator A5005685754 @default.
- W2593965944 creator A5014533589 @default.
- W2593965944 creator A5017185598 @default.
- W2593965944 creator A5019144958 @default.
- W2593965944 creator A5050866757 @default.
- W2593965944 creator A5087495619 @default.
- W2593965944 date "2013-02-12" @default.
- W2593965944 modified "2023-09-24" @default.
- W2593965944 title "Weakness Is Independent of Fatigue in Diverse Neuromuscular Diseases (P03.049)" @default.
- W2593965944 hasPublicationYear "2013" @default.
- W2593965944 type Work @default.
- W2593965944 sameAs 2593965944 @default.
- W2593965944 citedByCount "0" @default.
- W2593965944 crossrefType "journal-article" @default.
- W2593965944 hasAuthorship W2593965944A5002489918 @default.
- W2593965944 hasAuthorship W2593965944A5005685754 @default.
- W2593965944 hasAuthorship W2593965944A5014533589 @default.
- W2593965944 hasAuthorship W2593965944A5017185598 @default.
- W2593965944 hasAuthorship W2593965944A5019144958 @default.
- W2593965944 hasAuthorship W2593965944A5050866757 @default.
- W2593965944 hasAuthorship W2593965944A5087495619 @default.
- W2593965944 hasConcept C114614502 @default.
- W2593965944 hasConcept C126322002 @default.
- W2593965944 hasConcept C141071460 @default.
- W2593965944 hasConcept C161921814 @default.
- W2593965944 hasConcept C1862650 @default.
- W2593965944 hasConcept C2776356578 @default.
- W2593965944 hasConcept C2776418732 @default.
- W2593965944 hasConcept C2776874296 @default.
- W2593965944 hasConcept C2777515770 @default.
- W2593965944 hasConcept C2778105408 @default.
- W2593965944 hasConcept C2779134260 @default.
- W2593965944 hasConcept C2780247198 @default.
- W2593965944 hasConcept C2908647359 @default.
- W2593965944 hasConcept C33923547 @default.
- W2593965944 hasConcept C71924100 @default.
- W2593965944 hasConcept C99454951 @default.
- W2593965944 hasConcept C99508421 @default.
- W2593965944 hasConceptScore W2593965944C114614502 @default.
- W2593965944 hasConceptScore W2593965944C126322002 @default.
- W2593965944 hasConceptScore W2593965944C141071460 @default.
- W2593965944 hasConceptScore W2593965944C161921814 @default.
- W2593965944 hasConceptScore W2593965944C1862650 @default.
- W2593965944 hasConceptScore W2593965944C2776356578 @default.
- W2593965944 hasConceptScore W2593965944C2776418732 @default.
- W2593965944 hasConceptScore W2593965944C2776874296 @default.
- W2593965944 hasConceptScore W2593965944C2777515770 @default.
- W2593965944 hasConceptScore W2593965944C2778105408 @default.
- W2593965944 hasConceptScore W2593965944C2779134260 @default.
- W2593965944 hasConceptScore W2593965944C2780247198 @default.
- W2593965944 hasConceptScore W2593965944C2908647359 @default.
- W2593965944 hasConceptScore W2593965944C33923547 @default.
- W2593965944 hasConceptScore W2593965944C71924100 @default.
- W2593965944 hasConceptScore W2593965944C99454951 @default.
- W2593965944 hasConceptScore W2593965944C99508421 @default.
- W2593965944 hasLocation W25939659441 @default.
- W2593965944 hasOpenAccess W2593965944 @default.
- W2593965944 hasPrimaryLocation W25939659441 @default.
- W2593965944 hasRelatedWork W1497422561 @default.
- W2593965944 hasRelatedWork W1551411926 @default.
- W2593965944 hasRelatedWork W163378021 @default.
- W2593965944 hasRelatedWork W1782868933 @default.
- W2593965944 hasRelatedWork W1994855158 @default.
- W2593965944 hasRelatedWork W2078966280 @default.
- W2593965944 hasRelatedWork W2094756185 @default.
- W2593965944 hasRelatedWork W2120134743 @default.
- W2593965944 hasRelatedWork W2194343245 @default.
- W2593965944 hasRelatedWork W2333591877 @default.
- W2593965944 hasRelatedWork W2410995481 @default.
- W2593965944 hasRelatedWork W2521421673 @default.
- W2593965944 hasRelatedWork W2603756496 @default.
- W2593965944 hasRelatedWork W2772681474 @default.
- W2593965944 hasRelatedWork W2803412240 @default.
- W2593965944 hasRelatedWork W2884556938 @default.
- W2593965944 hasRelatedWork W3096130019 @default.
- W2593965944 hasRelatedWork W3175401201 @default.
- W2593965944 hasRelatedWork W61897702 @default.
- W2593965944 hasRelatedWork W1779058000 @default.
- W2593965944 hasVolume "80" @default.
- W2593965944 isParatext "false" @default.
- W2593965944 isRetracted "false" @default.
- W2593965944 magId "2593965944" @default.
- W2593965944 workType "article" @default.