FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594155777> ?p ?o ?g. }

• W2594155777 endingPage "32432" @default.
• W2594155777 startingPage "32419" @default.
• W2594155777 abstract "// Lindsay F. Goodale 1,6 , Soren Hayrabedyan 2 , Krassimira Todorova 2 , Roumen Roussev 3 , Sivakumar Ramu 3,8 , Christopher Stamatkin 3,9 , Carolyn B. Coulam 3 , Eytan R. Barnea 4,5,* and Robert O. Gilbert 1,7,* 1 Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA 2 Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria 3 CARI Reproductive Institute, Chicago, IL, USA 4 BioIncept, LLC, Cherry Hill, NJ, USA 5 Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, NJ, USA 6 Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA 7 Ross University School of Veterinary Medicine, Basseterre, St. Kitts, West Indies 8 Promigen Life Sciences, Downers Grove, IL, USA 9 Therapeutic Validation Core, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA * These authors have contributed equally to this work Correspondence to: Eytan R. Barnea, email: // Keywords : recurrent pregnancy loss, preImplantation factor (PIF), oxidative stress, PDI, embryo, Autophagy Received : December 05, 2016 Accepted : February 22, 2017 Published : March 08, 2017 Abstract Recurrent pregnancy loss (RPL) affects 2-3% of couples. Despite a detailed work-up, the etiology is frequently undefined, leading to non-targeted therapy. Viable embryos and placentae express PreImplantation Factor (PIF). Maternal circulating PIF regulates systemic immunity and reduces circulating natural killer cells cytotoxicity in RPL patients. PIF promotes singly cultured embryos’ development while anti-PIF antibody abrogates it. RPL serum induced embryo toxicity is negated by PIF. We report that PIF rescues delayed embryo development caused by <3 kDa RPL serum fraction likely by reducing reactive oxygen species (ROS). We reveal that protein disulfide isomerase/thioredoxin (PDI/TRX) is a prime PIF target in the embryo, rendering it an important ROS scavenger. The 16F16-PDI/TRX inhibitor drastically reduced blastocyst development while exogenous PIF increased >2 fold the number of embryos reaching the blastocyst stage. Mechanistically, PDI-inhibitor preferentially binds covalently to oxidized PDI over its reduced form where PIF avidly binds. PIF by targeting PDI/TRX at a distinct site limits the inhibitor’s pro-oxidative effects. The >3kDa RPL serum increased embryo demise by three-fold, an effect negated by PIF. However, embryo toxicity was not associated with the presence of putative anti-PIF antibodies. Collectively, PIF protects cultured embryos both against ROS, and higher molecular weight toxins. Using PIF for optimizing in vitro fertilization embryos development and reducing RPL is warranted." @default.
• W2594155777 created "2017-03-16" @default.
• W2594155777 creator A5018046573 @default.
• W2594155777 creator A5022083591 @default.
• W2594155777 creator A5026912968 @default.
• W2594155777 creator A5038352294 @default.
• W2594155777 creator A5040100986 @default.
• W2594155777 creator A5040939595 @default.
• W2594155777 creator A5056148869 @default.
• W2594155777 creator A5062683181 @default.
• W2594155777 creator A5062837908 @default.
• W2594155777 date "2017-03-08" @default.
• W2594155777 modified "2023-09-25" @default.
• W2594155777 title "PreImplantation factor (PIF) protects cultured embryos against oxidative stress: relevance for recurrent pregnancy loss (RPL) therapy" @default.
• W2594155777 cites W1010229819 @default.
• W2594155777 cites W1555616027 @default.
• W2594155777 cites W1562480431 @default.
• W2594155777 cites W1934185311 @default.
• W2594155777 cites W1971218841 @default.
• W2594155777 cites W1971662858 @default.
• W2594155777 cites W1973670440 @default.
• W2594155777 cites W1975287389 @default.
• W2594155777 cites W1976282051 @default.
• W2594155777 cites W1976654512 @default.
• W2594155777 cites W1978856408 @default.
• W2594155777 cites W1979573730 @default.
• W2594155777 cites W1982078589 @default.
• W2594155777 cites W1983398005 @default.
• W2594155777 cites W1985616824 @default.
• W2594155777 cites W1987533556 @default.
• W2594155777 cites W1994532961 @default.
• W2594155777 cites W2001244991 @default.
• W2594155777 cites W2015902113 @default.
• W2594155777 cites W2016487803 @default.
• W2594155777 cites W2028586094 @default.
• W2594155777 cites W2029112137 @default.
• W2594155777 cites W2034939363 @default.
• W2594155777 cites W2037463361 @default.
• W2594155777 cites W2037872763 @default.
• W2594155777 cites W2040182585 @default.
• W2594155777 cites W2042500091 @default.
• W2594155777 cites W2044570219 @default.
• W2594155777 cites W2051032344 @default.
• W2594155777 cites W2051038137 @default.
• W2594155777 cites W2065161076 @default.
• W2594155777 cites W2069794343 @default.
• W2594155777 cites W2074458732 @default.
• W2594155777 cites W2080559577 @default.
• W2594155777 cites W2081912151 @default.
• W2594155777 cites W2091725828 @default.
• W2594155777 cites W2091874007 @default.
• W2594155777 cites W2094106959 @default.
• W2594155777 cites W2096203711 @default.
• W2594155777 cites W2098627094 @default.
• W2594155777 cites W2101458866 @default.
• W2594155777 cites W2107098688 @default.
• W2594155777 cites W2109388963 @default.
• W2594155777 cites W2110502567 @default.
• W2594155777 cites W2116762882 @default.
• W2594155777 cites W2122798086 @default.
• W2594155777 cites W2126079531 @default.
• W2594155777 cites W2141697501 @default.
• W2594155777 cites W2150899581 @default.
• W2594155777 cites W2152639767 @default.
• W2594155777 cites W2158130741 @default.
• W2594155777 cites W2163411496 @default.
• W2594155777 cites W2164348008 @default.
• W2594155777 cites W2165399346 @default.
• W2594155777 cites W2170719307 @default.
• W2594155777 cites W2270554445 @default.
• W2594155777 cites W2275098370 @default.
• W2594155777 cites W2321852122 @default.
• W2594155777 cites W2334083216 @default.
• W2594155777 cites W2344404994 @default.
• W2594155777 cites W2464103642 @default.
• W2594155777 cites W2559515124 @default.
• W2594155777 doi "https://doi.org/10.18632/oncotarget.16028" @default.
• W2594155777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6324672" @default.
• W2594155777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30647875" @default.
• W2594155777 hasPublicationYear "2017" @default.
• W2594155777 type Work @default.
• W2594155777 sameAs 2594155777 @default.
• W2594155777 citedByCount "13" @default.
• W2594155777 countsByYear W25941557772017 @default.
• W2594155777 countsByYear W25941557772018 @default.
• W2594155777 countsByYear W25941557772019 @default.
• W2594155777 countsByYear W25941557772020 @default.
• W2594155777 countsByYear W25941557772021 @default.
• W2594155777 countsByYear W25941557772022 @default.
• W2594155777 countsByYear W25941557772023 @default.
• W2594155777 crossrefType "journal-article" @default.
• W2594155777 hasAuthorship W2594155777A5018046573 @default.
• W2594155777 hasAuthorship W2594155777A5022083591 @default.
• W2594155777 hasAuthorship W2594155777A5026912968 @default.
• W2594155777 hasAuthorship W2594155777A5038352294 @default.
• W2594155777 hasAuthorship W2594155777A5040100986 @default.
• W2594155777 hasAuthorship W2594155777A5040939595 @default.
• W2594155777 hasAuthorship W2594155777A5056148869 @default.

• next