FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594213840> ?p ?o ?g. }

• W2594213840 endingPage "140" @default.
• W2594213840 startingPage "129" @default.
• W2594213840 abstract "Poor water solubility and slow dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Simvastatin is poorly water-soluble drug and its bioavailability is very low from its crystalline form. The purpose of the present investigation was to increase the solubility and dissolution rate of simvastatin by the preparation of nanosuspension by nanoprecipitation technique at laboratory scale. Prepared nanosuspension was evaluated for its particle size and in vitro dissolution study and characterized by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). A 23 factorial design was employed to study the effect of independent variables, amount of PVPK- 30 (X1), amount of SLS (X2) and organic to aqueous solvent ratio (X3) on dependent variables, particle size (nm) and time required to release 80% of drug (t80). The relationship between the dependent and independent variables was further elucidated using multiple liner regression analysis (MLRA). The obtained results showed that particle size (nm) and rate of dissolution has been improved when nanosuspension prepared with the higher concentration of PVPK-30 with the higher concentration of SLS and lower concentration of organic to aqueous ratio, The rate of dissolution of the optimized nanosuspension was enhanced (80% in 20min), relative to micronized suspension of simvastatin (7.03% in 20 min), mainly due to the formation of nanosized particles. These results indicate the suitability of 23 factorial design for preparation of simvastatin loaded nanosuspension significantly improved in vitro dissolution rate, and thus possibly enhance fast onset of therapeutic drug effect." @default.
• W2594213840 created "2017-03-16" @default.
• W2594213840 creator A5005335495 @default.
• W2594213840 creator A5033136334 @default.
• W2594213840 creator A5040520670 @default.
• W2594213840 creator A5058508949 @default.
• W2594213840 date "2011-01-01" @default.
• W2594213840 modified "2023-09-22" @default.
• W2594213840 title "Formulation, Optimization and characterization of Simvastatin Nanosuspension prepared by nanoprecipitation technique" @default.
• W2594213840 hasPublicationYear "2011" @default.
• W2594213840 type Work @default.
• W2594213840 sameAs 2594213840 @default.
• W2594213840 citedByCount "12" @default.
• W2594213840 countsByYear W25942138402013 @default.
• W2594213840 countsByYear W25942138402014 @default.
• W2594213840 countsByYear W25942138402015 @default.
• W2594213840 countsByYear W25942138402016 @default.
• W2594213840 countsByYear W25942138402017 @default.
• W2594213840 countsByYear W25942138402019 @default.
• W2594213840 countsByYear W25942138402020 @default.
• W2594213840 crossrefType "journal-article" @default.
• W2594213840 hasAuthorship W2594213840A5005335495 @default.
• W2594213840 hasAuthorship W2594213840A5033136334 @default.
• W2594213840 hasAuthorship W2594213840A5040520670 @default.
• W2594213840 hasAuthorship W2594213840A5058508949 @default.
• W2594213840 hasConcept C105341887 @default.
• W2594213840 hasConcept C105795698 @default.
• W2594213840 hasConcept C121332964 @default.
• W2594213840 hasConcept C127413603 @default.
• W2594213840 hasConcept C13965031 @default.
• W2594213840 hasConcept C147789679 @default.
• W2594213840 hasConcept C155574463 @default.
• W2594213840 hasConcept C169222746 @default.
• W2594213840 hasConcept C178790620 @default.
• W2594213840 hasConcept C181389837 @default.
• W2594213840 hasConcept C184651966 @default.
• W2594213840 hasConcept C185592680 @default.
• W2594213840 hasConcept C187530423 @default.
• W2594213840 hasConcept C192562407 @default.
• W2594213840 hasConcept C202444582 @default.
• W2594213840 hasConcept C2776329913 @default.
• W2594213840 hasConcept C2780471494 @default.
• W2594213840 hasConcept C33923547 @default.
• W2594213840 hasConcept C39519442 @default.
• W2594213840 hasConcept C42360764 @default.
• W2594213840 hasConcept C43617362 @default.
• W2594213840 hasConcept C5961521 @default.
• W2594213840 hasConcept C71924100 @default.
• W2594213840 hasConcept C88380143 @default.
• W2594213840 hasConcept C97355855 @default.
• W2594213840 hasConcept C98274493 @default.
• W2594213840 hasConceptScore W2594213840C105341887 @default.
• W2594213840 hasConceptScore W2594213840C105795698 @default.
• W2594213840 hasConceptScore W2594213840C121332964 @default.
• W2594213840 hasConceptScore W2594213840C127413603 @default.
• W2594213840 hasConceptScore W2594213840C13965031 @default.
• W2594213840 hasConceptScore W2594213840C147789679 @default.
• W2594213840 hasConceptScore W2594213840C155574463 @default.
• W2594213840 hasConceptScore W2594213840C169222746 @default.
• W2594213840 hasConceptScore W2594213840C178790620 @default.
• W2594213840 hasConceptScore W2594213840C181389837 @default.
• W2594213840 hasConceptScore W2594213840C184651966 @default.
• W2594213840 hasConceptScore W2594213840C185592680 @default.
• W2594213840 hasConceptScore W2594213840C187530423 @default.
• W2594213840 hasConceptScore W2594213840C192562407 @default.
• W2594213840 hasConceptScore W2594213840C202444582 @default.
• W2594213840 hasConceptScore W2594213840C2776329913 @default.
• W2594213840 hasConceptScore W2594213840C2780471494 @default.
• W2594213840 hasConceptScore W2594213840C33923547 @default.
• W2594213840 hasConceptScore W2594213840C39519442 @default.
• W2594213840 hasConceptScore W2594213840C42360764 @default.
• W2594213840 hasConceptScore W2594213840C43617362 @default.
• W2594213840 hasConceptScore W2594213840C5961521 @default.
• W2594213840 hasConceptScore W2594213840C71924100 @default.
• W2594213840 hasConceptScore W2594213840C88380143 @default.
• W2594213840 hasConceptScore W2594213840C97355855 @default.
• W2594213840 hasConceptScore W2594213840C98274493 @default.
• W2594213840 hasIssue "2" @default.
• W2594213840 hasLocation W25942138401 @default.
• W2594213840 hasOpenAccess W2594213840 @default.
• W2594213840 hasPrimaryLocation W25942138401 @default.
• W2594213840 hasRelatedWork W1503031844 @default.
• W2594213840 hasRelatedWork W2016971948 @default.
• W2594213840 hasRelatedWork W2028536670 @default.
• W2594213840 hasRelatedWork W2028724994 @default.
• W2594213840 hasRelatedWork W2188654845 @default.
• W2594213840 hasRelatedWork W2317645922 @default.
• W2594213840 hasRelatedWork W2336186817 @default.
• W2594213840 hasRelatedWork W2357617931 @default.
• W2594213840 hasRelatedWork W2368045118 @default.
• W2594213840 hasRelatedWork W2490617707 @default.
• W2594213840 hasRelatedWork W2519616849 @default.
• W2594213840 hasRelatedWork W2572614671 @default.
• W2594213840 hasRelatedWork W2590388807 @default.
• W2594213840 hasRelatedWork W2595267155 @default.
• W2594213840 hasRelatedWork W2738507012 @default.
• W2594213840 hasRelatedWork W2746431934 @default.
• W2594213840 hasRelatedWork W3031291235 @default.

• next