Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594220918> ?p ?o ?g. }
- W2594220918 endingPage "6085" @default.
- W2594220918 startingPage "6076" @default.
- W2594220918 abstract "Nutrient-driven O-GlcNAcylation is strikingly abundant in the brain and has been linked to development and neurodegenerative disease. We selectively targeted the O-GlcNAcase (Oga) gene in the mouse brain to define the role of O-GlcNAc cycling in the central nervous system. Brain knockout animals exhibited dramatically increased brain O-GlcNAc levels and pleiotropic phenotypes, including early-onset obesity, growth defects, and metabolic dysregulation. Anatomical defects in the Oga knockout included delayed brain differentiation and neurogenesis as well as abnormal proliferation accompanying a developmental delay. The molecular basis for these defects included transcriptional changes accompanying differentiating embryonic stem cells. In Oga KO mouse ES cells, we observed pronounced changes in expression of pluripotency markers, including Sox2, Nanog, and Otx2. These findings link the O-GlcNAc modification to mammalian neurogenesis and highlight the role of this nutrient-sensing pathway in developmental plasticity and metabolic homeostasis." @default.
- W2594220918 created "2017-03-16" @default.
- W2594220918 creator A5012249665 @default.
- W2594220918 creator A5049078993 @default.
- W2594220918 creator A5052691073 @default.
- W2594220918 creator A5059291029 @default.
- W2594220918 creator A5081114129 @default.
- W2594220918 date "2017-04-01" @default.
- W2594220918 modified "2023-10-18" @default.
- W2594220918 title "Nutrient-driven O-linked N-acetylglucosamine (O-GlcNAc) cycling impacts neurodevelopmental timing and metabolism" @default.
- W2594220918 cites W1570460795 @default.
- W2594220918 cites W1599732984 @default.
- W2594220918 cites W1850749226 @default.
- W2594220918 cites W1985039567 @default.
- W2594220918 cites W1988250463 @default.
- W2594220918 cites W1992182372 @default.
- W2594220918 cites W1993052072 @default.
- W2594220918 cites W1997650538 @default.
- W2594220918 cites W2018077021 @default.
- W2594220918 cites W2023103979 @default.
- W2594220918 cites W2040714286 @default.
- W2594220918 cites W2041801261 @default.
- W2594220918 cites W2051948190 @default.
- W2594220918 cites W2052162377 @default.
- W2594220918 cites W2052369998 @default.
- W2594220918 cites W2057608998 @default.
- W2594220918 cites W2057716523 @default.
- W2594220918 cites W2061999440 @default.
- W2594220918 cites W2075358633 @default.
- W2594220918 cites W2089465141 @default.
- W2594220918 cites W2090211150 @default.
- W2594220918 cites W2092412966 @default.
- W2594220918 cites W2094006348 @default.
- W2594220918 cites W2099236073 @default.
- W2594220918 cites W2105086774 @default.
- W2594220918 cites W2107089340 @default.
- W2594220918 cites W2107277218 @default.
- W2594220918 cites W2114688343 @default.
- W2594220918 cites W2119754857 @default.
- W2594220918 cites W2120036668 @default.
- W2594220918 cites W2120667767 @default.
- W2594220918 cites W2137404591 @default.
- W2594220918 cites W2140409722 @default.
- W2594220918 cites W2144814555 @default.
- W2594220918 cites W2149739033 @default.
- W2594220918 cites W2161402141 @default.
- W2594220918 cites W2166815183 @default.
- W2594220918 cites W2192080449 @default.
- W2594220918 cites W2257073739 @default.
- W2594220918 cites W2301431651 @default.
- W2594220918 cites W2543063006 @default.
- W2594220918 cites W2597023523 @default.
- W2594220918 doi "https://doi.org/10.1074/jbc.m116.774042" @default.
- W2594220918 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5391740" @default.
- W2594220918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28246173" @default.
- W2594220918 hasPublicationYear "2017" @default.
- W2594220918 type Work @default.
- W2594220918 sameAs 2594220918 @default.
- W2594220918 citedByCount "59" @default.
- W2594220918 countsByYear W25942209182017 @default.
- W2594220918 countsByYear W25942209182018 @default.
- W2594220918 countsByYear W25942209182019 @default.
- W2594220918 countsByYear W25942209182020 @default.
- W2594220918 countsByYear W25942209182021 @default.
- W2594220918 countsByYear W25942209182022 @default.
- W2594220918 countsByYear W25942209182023 @default.
- W2594220918 crossrefType "journal-article" @default.
- W2594220918 hasAuthorship W2594220918A5012249665 @default.
- W2594220918 hasAuthorship W2594220918A5049078993 @default.
- W2594220918 hasAuthorship W2594220918A5052691073 @default.
- W2594220918 hasAuthorship W2594220918A5059291029 @default.
- W2594220918 hasAuthorship W2594220918A5081114129 @default.
- W2594220918 hasBestOaLocation W25942209181 @default.
- W2594220918 hasConcept C104317684 @default.
- W2594220918 hasConcept C107459253 @default.
- W2594220918 hasConcept C134018914 @default.
- W2594220918 hasConcept C145103041 @default.
- W2594220918 hasConcept C169760540 @default.
- W2594220918 hasConcept C182704531 @default.
- W2594220918 hasConcept C207701140 @default.
- W2594220918 hasConcept C2491326 @default.
- W2594220918 hasConcept C2777933648 @default.
- W2594220918 hasConcept C4746552 @default.
- W2594220918 hasConcept C511355011 @default.
- W2594220918 hasConcept C55493867 @default.
- W2594220918 hasConcept C86803240 @default.
- W2594220918 hasConcept C95444343 @default.
- W2594220918 hasConceptScore W2594220918C104317684 @default.
- W2594220918 hasConceptScore W2594220918C107459253 @default.
- W2594220918 hasConceptScore W2594220918C134018914 @default.
- W2594220918 hasConceptScore W2594220918C145103041 @default.
- W2594220918 hasConceptScore W2594220918C169760540 @default.
- W2594220918 hasConceptScore W2594220918C182704531 @default.
- W2594220918 hasConceptScore W2594220918C207701140 @default.
- W2594220918 hasConceptScore W2594220918C2491326 @default.
- W2594220918 hasConceptScore W2594220918C2777933648 @default.
- W2594220918 hasConceptScore W2594220918C4746552 @default.
- W2594220918 hasConceptScore W2594220918C511355011 @default.