Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594239134> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2594239134 abstract "Multiple sclerosis is an inflammatory and demyelinating multifactorial disease that results from the interplay between environmental factors and a susceptible genetic background. Omega (ω)-3/ω-6 polyunsaturated fatty acids (PUFAs) and some vitamins have been shown to reduce the number and severity of relapses and the overall progression of disability in multiple sclerosis patients, however clinical trials remain inconclusive due to a plethora of reasons. In this randomized, double blinded, placebo controlled trial aiming to provide concrete conclusions for the role of PUFAs and vitamins A and E (both gamma (γ) and alpha (α)) in multiple sclerosis. By measuring the incorporation and changes of the lipid composition in red blood cell (RBC) membranes before and after the dietary intervention, and by correlating the efficacy of the different interventions with disease progression, it was shown that supplementation with these specific molecules (that can either act on their own or synergistically) could probably cause the decrease of arachidonic acid (AA) and linoleic acid (LA) from the RBC membranes and the subsequent substitution by eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). These events parallel the clinical observations where this can be correlated with the increased number of relapse activity occurring in the first six months of treatment and later with a prolonged period of remission. Supplementation with the mixture of PUFAs (both ω3 and ω6), vitamin E as gamma tocopherol significantly reduced the annualised relapse rate (ARR) and the risk of sustained disability progression without any reported serious adverse events." @default.
- W2594239134 created "2017-03-16" @default.
- W2594239134 creator A5057621491 @default.
- W2594239134 date "2016-07-01" @default.
- W2594239134 modified "2023-09-23" @default.
- W2594239134 title "The effects of Omega-3, Omega-6 Polyunsaturated Fatty Acids (PUFAs) and Vitamin E on patients with the remitting-relapsing (RR) form of Multiple Sclerosis (MS) in Cyprus" @default.
- W2594239134 hasPublicationYear "2016" @default.
- W2594239134 type Work @default.
- W2594239134 sameAs 2594239134 @default.
- W2594239134 citedByCount "0" @default.
- W2594239134 crossrefType "dissertation" @default.
- W2594239134 hasAuthorship W2594239134A5057621491 @default.
- W2594239134 hasConcept C124490489 @default.
- W2594239134 hasConcept C126322002 @default.
- W2594239134 hasConcept C134018914 @default.
- W2594239134 hasConcept C142724271 @default.
- W2594239134 hasConcept C168563851 @default.
- W2594239134 hasConcept C181199279 @default.
- W2594239134 hasConcept C19038510 @default.
- W2594239134 hasConcept C197934379 @default.
- W2594239134 hasConcept C203014093 @default.
- W2594239134 hasConcept C204787440 @default.
- W2594239134 hasConcept C27081682 @default.
- W2594239134 hasConcept C2776091944 @default.
- W2594239134 hasConcept C2777171753 @default.
- W2594239134 hasConcept C2777551382 @default.
- W2594239134 hasConcept C2778004101 @default.
- W2594239134 hasConcept C2778078955 @default.
- W2594239134 hasConcept C2780640218 @default.
- W2594239134 hasConcept C2780809830 @default.
- W2594239134 hasConcept C543025807 @default.
- W2594239134 hasConcept C55493867 @default.
- W2594239134 hasConcept C71924100 @default.
- W2594239134 hasConcept C86803240 @default.
- W2594239134 hasConcept C90924648 @default.
- W2594239134 hasConceptScore W2594239134C124490489 @default.
- W2594239134 hasConceptScore W2594239134C126322002 @default.
- W2594239134 hasConceptScore W2594239134C134018914 @default.
- W2594239134 hasConceptScore W2594239134C142724271 @default.
- W2594239134 hasConceptScore W2594239134C168563851 @default.
- W2594239134 hasConceptScore W2594239134C181199279 @default.
- W2594239134 hasConceptScore W2594239134C19038510 @default.
- W2594239134 hasConceptScore W2594239134C197934379 @default.
- W2594239134 hasConceptScore W2594239134C203014093 @default.
- W2594239134 hasConceptScore W2594239134C204787440 @default.
- W2594239134 hasConceptScore W2594239134C27081682 @default.
- W2594239134 hasConceptScore W2594239134C2776091944 @default.
- W2594239134 hasConceptScore W2594239134C2777171753 @default.
- W2594239134 hasConceptScore W2594239134C2777551382 @default.
- W2594239134 hasConceptScore W2594239134C2778004101 @default.
- W2594239134 hasConceptScore W2594239134C2778078955 @default.
- W2594239134 hasConceptScore W2594239134C2780640218 @default.
- W2594239134 hasConceptScore W2594239134C2780809830 @default.
- W2594239134 hasConceptScore W2594239134C543025807 @default.
- W2594239134 hasConceptScore W2594239134C55493867 @default.
- W2594239134 hasConceptScore W2594239134C71924100 @default.
- W2594239134 hasConceptScore W2594239134C86803240 @default.
- W2594239134 hasConceptScore W2594239134C90924648 @default.
- W2594239134 hasLocation W25942391341 @default.
- W2594239134 hasOpenAccess W2594239134 @default.
- W2594239134 hasPrimaryLocation W25942391341 @default.
- W2594239134 hasRelatedWork W1502799429 @default.
- W2594239134 hasRelatedWork W1983925259 @default.
- W2594239134 hasRelatedWork W2020078559 @default.
- W2594239134 hasRelatedWork W2053612684 @default.
- W2594239134 hasRelatedWork W2070626698 @default.
- W2594239134 hasRelatedWork W2073749311 @default.
- W2594239134 hasRelatedWork W2090453246 @default.
- W2594239134 hasRelatedWork W2094017457 @default.
- W2594239134 hasRelatedWork W2123164235 @default.
- W2594239134 hasRelatedWork W2133858157 @default.
- W2594239134 hasRelatedWork W2139643410 @default.
- W2594239134 hasRelatedWork W2215374705 @default.
- W2594239134 hasRelatedWork W2260015110 @default.
- W2594239134 hasRelatedWork W2334837766 @default.
- W2594239134 hasRelatedWork W2340299350 @default.
- W2594239134 hasRelatedWork W2592739144 @default.
- W2594239134 hasRelatedWork W2793787049 @default.
- W2594239134 hasRelatedWork W2963889141 @default.
- W2594239134 hasRelatedWork W3029797194 @default.
- W2594239134 hasRelatedWork W46335509 @default.
- W2594239134 isParatext "false" @default.
- W2594239134 isRetracted "false" @default.
- W2594239134 magId "2594239134" @default.
- W2594239134 workType "dissertation" @default.