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• W2594277674 abstract "Colorectal cancer (CRC) is a major worldwide health problem due to its high prevalence and mortality rate. T-cell intracellular antigen 1 (TIA1) is an important tumor suppressor involved in many aspects of carcinogenesis and cancer development. How TIA1 expression is regulated during CRC development remains to be carefully elucidated.In CRC tissue sample pairs, TIA1 protein and mRNA levels were monitored by Western blot and qRT-PCR, respectively. Combining meta-analysis and miRNA target prediction software, we could predict microRNAs that targeted TIA1. Next, three CRC cell lines (SW480, Caco2 and HT29) were used to demonstrate the direct targeting of TIA1 by miR-19a. In addition, we investigated the biological effects of TIA1 inhibition by miR-19a both in vitro by CCK-8, EdU, Transwell, Ki67 immunofluorescence and Colony formation assays and in vivo by a xenograft mice model.In colorectal cancer (CRC), we found that TIA1 protein, but not its mRNA, was downregulated. We predicted that TIA1 was a target of miR-19a and validated that miR-19a binded directly to the 3'-UTR of TIA1 mRNA. miR-19a could promote cell proliferation and migration in CRC cells and accelerated tumor growth in xenograft mice by targeting TIA1.This study highlights an oncomiR role for miR-19a in regulating TIA1 in CRC and suggests that miR-19a may be a novel molecular therapeutic target for CRC." @default.
• W2594277674 created "2017-03-16" @default.
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• W2594277674 date "2017-03-04" @default.
• W2594277674 modified "2023-10-17" @default.
• W2594277674 title "miR-19a promotes colorectal cancer proliferation and migration by targeting TIA1" @default.
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• W2594277674 cites W1566568466 @default.
• W2594277674 cites W1648301895 @default.
• W2594277674 cites W1655178001 @default.
• W2594277674 cites W1753657885 @default.
• W2594277674 cites W1964072966 @default.
• W2594277674 cites W1969003435 @default.
• W2594277674 cites W1969679584 @default.
• W2594277674 cites W1982529507 @default.
• W2594277674 cites W1989504358 @default.
• W2594277674 cites W2002404925 @default.
• W2594277674 cites W2012648887 @default.
• W2594277674 cites W2014518368 @default.
• W2594277674 cites W2018507242 @default.
• W2594277674 cites W2019678870 @default.
• W2594277674 cites W2021536610 @default.
• W2594277674 cites W2021543366 @default.
• W2594277674 cites W2023893507 @default.
• W2594277674 cites W2025296756 @default.
• W2594277674 cites W2040191060 @default.
• W2594277674 cites W2043435109 @default.
• W2594277674 cites W2043704189 @default.
• W2594277674 cites W2044782990 @default.
• W2594277674 cites W2046314136 @default.
• W2594277674 cites W2046930479 @default.
• W2594277674 cites W2050869737 @default.
• W2594277674 cites W2053490054 @default.
• W2594277674 cites W2059200009 @default.
• W2594277674 cites W2059382687 @default.
• W2594277674 cites W2061452886 @default.
• W2594277674 cites W2062290101 @default.
• W2594277674 cites W2080719056 @default.
• W2594277674 cites W2082044596 @default.
• W2594277674 cites W2082639157 @default.
• W2594277674 cites W2083381199 @default.
• W2594277674 cites W2085592081 @default.
• W2594277674 cites W2090017296 @default.
• W2594277674 cites W2090312211 @default.
• W2594277674 cites W2095692554 @default.
• W2594277674 cites W2096528587 @default.
• W2594277674 cites W2105186321 @default.
• W2594277674 cites W2108057660 @default.
• W2594277674 cites W2116365126 @default.
• W2594277674 cites W2117391818 @default.
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• W2594277674 cites W2127501324 @default.
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• W2594277674 cites W2138366746 @default.
• W2594277674 cites W2138664009 @default.
• W2594277674 cites W2151483495 @default.
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• W2594277674 cites W2159807040 @default.
• W2594277674 cites W2161693225 @default.
• W2594277674 cites W2163199119 @default.
• W2594277674 cites W2163718382 @default.
• W2594277674 cites W2165284248 @default.
• W2594277674 cites W2167604826 @default.
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• W2594277674 doi "https://doi.org/10.1186/s12943-017-0625-8" @default.
• W2594277674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5336638" @default.
• W2594277674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28257633" @default.
• W2594277674 hasPublicationYear "2017" @default.
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