Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594297890> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2594297890 abstract "Multipotent mesenchymal stromal cells (MSCs) have neuro- and glial protective properties and can influence the differentiation and maturation of oligodendrocytes. Clinical trials employing autologous MSC transplantation for the treatment of multiple sclerosis (MS) and other neurodegenerative diseases are ongoing. Extending previous studies, we have performed detailed analysis of the phenotype of MSCs derived from patients with MS using marrow samples donated as part of the ‘ACTiMuS’ trial which is examining the efficacy of unfractionated autologous bone marrow in progressive MS (NCT01815632). In keeping with previous findings, MS MSCs have comparable mesenchymal differentiation potential to MSCs isolated from control subjects. However, donor age negatively correlates with clonogenic potential and premature senescence. Using in vitro models of neuroglial toxicity, we have demonstrated that the neuroglial protective effects of soluble factors produced by MSCs decline with expansion in vitro. Significantly, media conditioned by MSCs isolated from patients with long duration of progressive disease have reduced neuroglial protective capacity. Using tandem mass spectroscopy, we have identified over 40 factors whose secretion by MSCs is altered in progressive MS. Further work will explore their relevance to MS pathogenesis and repair with the aim of identifying new drug candidates and optimisation of cell-based therapy for MS." @default.
- W2594297890 created "2017-03-16" @default.
- W2594297890 creator A5005260981 @default.
- W2594297890 creator A5019706393 @default.
- W2594297890 creator A5078057490 @default.
- W2594297890 creator A5081801856 @default.
- W2594297890 creator A5082004497 @default.
- W2594297890 creator A5090620300 @default.
- W2594297890 date "2016-11-15" @default.
- W2594297890 modified "2023-09-27" @default.
- W2594297890 title "IMPAIRED MSC-MEDIATED NEUROGLIAL PROTECTION IN PROGRESSIVE MS" @default.
- W2594297890 doi "https://doi.org/10.1136/jnnp-2016-315106.17" @default.
- W2594297890 hasPublicationYear "2016" @default.
- W2594297890 type Work @default.
- W2594297890 sameAs 2594297890 @default.
- W2594297890 citedByCount "0" @default.
- W2594297890 crossrefType "journal-article" @default.
- W2594297890 hasAuthorship W2594297890A5005260981 @default.
- W2594297890 hasAuthorship W2594297890A5019706393 @default.
- W2594297890 hasAuthorship W2594297890A5078057490 @default.
- W2594297890 hasAuthorship W2594297890A5081801856 @default.
- W2594297890 hasAuthorship W2594297890A5082004497 @default.
- W2594297890 hasAuthorship W2594297890A5090620300 @default.
- W2594297890 hasConcept C10882517 @default.
- W2594297890 hasConcept C117262875 @default.
- W2594297890 hasConcept C142724271 @default.
- W2594297890 hasConcept C198826908 @default.
- W2594297890 hasConcept C202751555 @default.
- W2594297890 hasConcept C203014093 @default.
- W2594297890 hasConcept C2780007613 @default.
- W2594297890 hasConcept C2780640218 @default.
- W2594297890 hasConcept C28328180 @default.
- W2594297890 hasConcept C502942594 @default.
- W2594297890 hasConcept C55493867 @default.
- W2594297890 hasConcept C71924100 @default.
- W2594297890 hasConcept C86803240 @default.
- W2594297890 hasConcept C95444343 @default.
- W2594297890 hasConceptScore W2594297890C10882517 @default.
- W2594297890 hasConceptScore W2594297890C117262875 @default.
- W2594297890 hasConceptScore W2594297890C142724271 @default.
- W2594297890 hasConceptScore W2594297890C198826908 @default.
- W2594297890 hasConceptScore W2594297890C202751555 @default.
- W2594297890 hasConceptScore W2594297890C203014093 @default.
- W2594297890 hasConceptScore W2594297890C2780007613 @default.
- W2594297890 hasConceptScore W2594297890C2780640218 @default.
- W2594297890 hasConceptScore W2594297890C28328180 @default.
- W2594297890 hasConceptScore W2594297890C502942594 @default.
- W2594297890 hasConceptScore W2594297890C55493867 @default.
- W2594297890 hasConceptScore W2594297890C71924100 @default.
- W2594297890 hasConceptScore W2594297890C86803240 @default.
- W2594297890 hasConceptScore W2594297890C95444343 @default.
- W2594297890 hasLocation W25942978901 @default.
- W2594297890 hasOpenAccess W2594297890 @default.
- W2594297890 hasPrimaryLocation W25942978901 @default.
- W2594297890 hasRelatedWork W1956624744 @default.
- W2594297890 hasRelatedWork W1993089779 @default.
- W2594297890 hasRelatedWork W2001501599 @default.
- W2594297890 hasRelatedWork W2016645461 @default.
- W2594297890 hasRelatedWork W2023519814 @default.
- W2594297890 hasRelatedWork W2041209855 @default.
- W2594297890 hasRelatedWork W2045586545 @default.
- W2594297890 hasRelatedWork W2085582924 @default.
- W2594297890 hasRelatedWork W2623884836 @default.
- W2594297890 hasRelatedWork W2751352478 @default.
- W2594297890 hasRelatedWork W2777496082 @default.
- W2594297890 hasRelatedWork W2800479952 @default.
- W2594297890 hasRelatedWork W2809862294 @default.
- W2594297890 hasRelatedWork W2944818786 @default.
- W2594297890 hasRelatedWork W2980432065 @default.
- W2594297890 hasRelatedWork W3000718433 @default.
- W2594297890 hasRelatedWork W3014738766 @default.
- W2594297890 hasRelatedWork W3038122116 @default.
- W2594297890 hasRelatedWork W3179241079 @default.
- W2594297890 hasRelatedWork W2184735445 @default.
- W2594297890 isParatext "false" @default.
- W2594297890 isRetracted "false" @default.
- W2594297890 magId "2594297890" @default.
- W2594297890 workType "article" @default.