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• W2594302014 abstract "Background and aims The development of adolescence psychological health over a 3-year period and its relationship to peripheral endothelial function and the hypothalamic-pituitary-adrenal (HPA)-axis activity were examined in a cohort of healthy adolescents in a longitudinal study. Methods A total of 162 adolescents (94 females) participated in both baseline (mean age 14.5 ± 1 years) and three-year follow-up studies. Psychological health was evaluated by self-report using the Beck Youth Inventories of Emotional and Social Impairment and the psychosomatic problem scale. Peripheral endothelial function was assessed using a peripheral artery tonometry device. The HPA-axis activity measured as cortisol awakening response (CAR) was assessed only at follow-up by collecting two saliva samples, immediately after awakening and 15 min later. Physical activity, smoking and parental education were assessed by questionnaires. Results Adolescents reported increased depression and decreased anger over three years, while only females reported increased psychosomatic complaints. Reduced peripheral endothelial function was associated with high level of anger (β = −0.332, p = 0.018) and disruptive behaviour (β = −0.390, p = 0.006) over three years in males, but not in females, after adjusting for covariates. Blunted cortisol awakening response was associated with high level of anxiety (β = −0.235, p = 0.017), depression (β = −0.203, p = 0.038), anger (β = −0.185, p = 0.048), and low level of self-concept (β = 0.289, p = 0.002) after adjusting for covariates. Conclusions High level of negative emotions during adolescence may have adverse effects on peripheral endothelial function and the regulation of the HPA-axis activity, while high level of self-concept might be protective." @default.
• W2594302014 created "2017-03-16" @default.
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• W2594302014 date "2017-06-01" @default.
• W2594302014 modified "2023-10-16" @default.
• W2594302014 title "Impact of psychological health on peripheral endothelial function and the HPA-axis activity in healthy adolescents" @default.
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• W2594302014 doi "https://doi.org/10.1016/j.atherosclerosis.2017.03.012" @default.
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