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- W2594305425 abstract "From a CH2Cl2 extract of the bark of Taxus wallichiana, six new taxoids, wallitaxanes A-F (1-6), were isolated, together with 29 known compounds. The structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. Wallitaxane D (4) was identified as an opened oxetane-type taxoid having the first naturally occurring C(H)-20 acetal group, while wallitaxanes E (5) and F (6) are representative of the rare abeo-taxoid class. The isolated compounds were evaluated for their α-glucosidase inhibitory activity and for cytotoxicity against the HeLa human cervical cancer cell line. In the present work, taxanes were found to exhibit α-glucosidase inhibitory activity for the first time, and wallitaxane A (1) showed the most potent effect, with an IC50 value of 3.6 μM. In turn, 7-epi-taxol (16) and 7-epi-10-deacetyltaxol (17) showed IC50 values of 0.05 and 0.085 nM, respectively, against HeLa cells." @default.
- W2594305425 created "2017-03-16" @default.
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- W2594305425 date "2017-02-27" @default.
- W2594305425 modified "2023-10-13" @default.
- W2594305425 title "α-Glucosidase Inhibitory and Cytotoxic Taxane Diterpenoids from the Stem Bark of <i>Taxus wallichiana</i>" @default.
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- W2594305425 doi "https://doi.org/10.1021/acs.jnatprod.7b00006" @default.
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