FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594306037> ?p ?o ?g. }

• W2594306037 endingPage "117822341769017" @default.
• W2594306037 startingPage "117822341769017" @default.
• W2594306037 abstract "This study aimed to investigate the effect of hydroalcoholic Achillea wilhelmsii C. Koch extract (HAWE) on phosphodiesterase 5 (PDE5) gene expression and cyclic guanosine 3',5' monophosphate (cGMP) signaling in the MCF-7 and MDA-Mb-468 cell lines. The effective dose (ED50) of HAWE was examined in both cell lines using a 3-(4,5-dimethylhiazol-2-yl)-2,5-diphenyltetrazolium bromide viability test, and the type of cell death was detected by flow cytometry. The expression of PDE5 and the concentration of cGMP were measured in a time-dependent manner in the ED50 by real-time polymerase chain reaction and a colorimetric assay, respectively. Treatment with HAWE showed 25 µg/mL to be the ED50 for both cell lines, and HAWE led to a reduction in the PDE5 messenger RNA expression. The intracellular cGMP increased in a time-dependent manner. The results showed that HAWE has an antiproliferative property in MCF-7 and MDA-Mb-468 cell lines through the cGMP pathway. Therefore, HAWE is a potential source to effectively isolate inhibitory PDE5." @default.
• W2594306037 created "2017-03-16" @default.
• W2594306037 creator A5025604158 @default.
• W2594306037 creator A5058011542 @default.
• W2594306037 creator A5068243198 @default.
• W2594306037 date "2017-01-01" @default.
• W2594306037 modified "2023-09-27" @default.
• W2594306037 title "Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3′,5′ Monophosphate by Hydroalcoholic <i>Achillea wilhelmsii</i> C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468" @default.
• W2594306037 cites W1539031135 @default.
• W2594306037 cites W1965726339 @default.
• W2594306037 cites W1967304952 @default.
• W2594306037 cites W1974639883 @default.
• W2594306037 cites W1992243371 @default.
• W2594306037 cites W1996628084 @default.
• W2594306037 cites W1997955037 @default.
• W2594306037 cites W2004567605 @default.
• W2594306037 cites W2011436901 @default.
• W2594306037 cites W2017588643 @default.
• W2594306037 cites W2025573005 @default.
• W2594306037 cites W2045073455 @default.
• W2594306037 cites W2047729795 @default.
• W2594306037 cites W2049472065 @default.
• W2594306037 cites W2065731223 @default.
• W2594306037 cites W2070115846 @default.
• W2594306037 cites W2070737114 @default.
• W2594306037 cites W2070897791 @default.
• W2594306037 cites W2096271770 @default.
• W2594306037 cites W2105462428 @default.
• W2594306037 cites W2105607387 @default.
• W2594306037 cites W2119621416 @default.
• W2594306037 cites W2123350513 @default.
• W2594306037 cites W2128846879 @default.
• W2594306037 cites W2160561644 @default.
• W2594306037 cites W2208114687 @default.
• W2594306037 cites W588985956 @default.
• W2594306037 cites W2029342781 @default.
• W2594306037 doi "https://doi.org/10.1177/1178223417690178" @default.
• W2594306037 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5391053" @default.
• W2594306037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28469435" @default.
• W2594306037 hasPublicationYear "2017" @default.
• W2594306037 type Work @default.
• W2594306037 sameAs 2594306037 @default.
• W2594306037 citedByCount "9" @default.
• W2594306037 countsByYear W25943060372017 @default.
• W2594306037 countsByYear W25943060372019 @default.
• W2594306037 countsByYear W25943060372020 @default.
• W2594306037 countsByYear W25943060372021 @default.
• W2594306037 countsByYear W25943060372022 @default.
• W2594306037 countsByYear W25943060372023 @default.
• W2594306037 crossrefType "journal-article" @default.
• W2594306037 hasAuthorship W2594306037A5025604158 @default.
• W2594306037 hasAuthorship W2594306037A5058011542 @default.
• W2594306037 hasAuthorship W2594306037A5068243198 @default.
• W2594306037 hasBestOaLocation W25943060371 @default.
• W2594306037 hasConcept C109541995 @default.
• W2594306037 hasConcept C121608353 @default.
• W2594306037 hasConcept C126322002 @default.
• W2594306037 hasConcept C134018914 @default.
• W2594306037 hasConcept C1491633281 @default.
• W2594306037 hasConcept C153911025 @default.
• W2594306037 hasConcept C181199279 @default.
• W2594306037 hasConcept C2776768464 @default.
• W2594306037 hasConcept C2777995097 @default.
• W2594306037 hasConcept C2780994212 @default.
• W2594306037 hasConcept C2994423619 @default.
• W2594306037 hasConcept C519581460 @default.
• W2594306037 hasConcept C53227056 @default.
• W2594306037 hasConcept C54355233 @default.
• W2594306037 hasConcept C553184892 @default.
• W2594306037 hasConcept C55493867 @default.
• W2594306037 hasConcept C62826618 @default.
• W2594306037 hasConcept C71924100 @default.
• W2594306037 hasConcept C74534348 @default.
• W2594306037 hasConcept C79879829 @default.
• W2594306037 hasConcept C81885089 @default.
• W2594306037 hasConcept C86803240 @default.
• W2594306037 hasConcept C96232424 @default.
• W2594306037 hasConcept C98274493 @default.
• W2594306037 hasConceptScore W2594306037C109541995 @default.
• W2594306037 hasConceptScore W2594306037C121608353 @default.
• W2594306037 hasConceptScore W2594306037C126322002 @default.
• W2594306037 hasConceptScore W2594306037C134018914 @default.
• W2594306037 hasConceptScore W2594306037C1491633281 @default.
• W2594306037 hasConceptScore W2594306037C153911025 @default.
• W2594306037 hasConceptScore W2594306037C181199279 @default.
• W2594306037 hasConceptScore W2594306037C2776768464 @default.
• W2594306037 hasConceptScore W2594306037C2777995097 @default.
• W2594306037 hasConceptScore W2594306037C2780994212 @default.
• W2594306037 hasConceptScore W2594306037C2994423619 @default.
• W2594306037 hasConceptScore W2594306037C519581460 @default.
• W2594306037 hasConceptScore W2594306037C53227056 @default.
• W2594306037 hasConceptScore W2594306037C54355233 @default.
• W2594306037 hasConceptScore W2594306037C553184892 @default.
• W2594306037 hasConceptScore W2594306037C55493867 @default.
• W2594306037 hasConceptScore W2594306037C62826618 @default.
• W2594306037 hasConceptScore W2594306037C71924100 @default.
• W2594306037 hasConceptScore W2594306037C74534348 @default.
• W2594306037 hasConceptScore W2594306037C79879829 @default.

• next