Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594315205> ?p ?o ?g. }
- W2594315205 abstract "Abstract The irreversibility of glomerulosclerotic changes depends on the degree of podocyte injury. We have previously demonstrated the endocytic translocation of podocin to the subcellular area in severely injured podocytes and found that this process is the primary disease trigger. Here we identified the protein sorting nexin 9 (SNX9) as a novel facilitator of podocin endocytosis in a yeast two-hybrid analysis. SNX9 is involved in clathrin-mediated endocytosis, actin rearrangement and vesicle transport regulation. Our results revealed and confirmed that SNX9 interacts with podocin exclusively through the Bin–Amphiphysin–Rvs (BAR) domain of SNX9. Immunofluorescence staining revealed the expression of SNX9 in response to podocyte adriamycin-induced injury both in vitro and in vivo . Finally, an analysis of human glomerular disease biopsy samples demonstrated strong SNX9 expression and co-localization with podocin in samples representative of severe podocyte injury, such as IgA nephropathy with poor prognosis, membranous nephropathy and focal segmental glomerulosclerosis. In conclusion, we identified SNX9 as a facilitator of podocin endocytosis in severe podocyte injury and demonstrated the expression of SNX9 in the podocytes of both nephropathy model mice and human patients with irreversible glomerular disease." @default.
- W2594315205 created "2017-03-16" @default.
- W2594315205 creator A5012874068 @default.
- W2594315205 creator A5020010316 @default.
- W2594315205 creator A5025616849 @default.
- W2594315205 creator A5037618983 @default.
- W2594315205 creator A5038076129 @default.
- W2594315205 creator A5040361880 @default.
- W2594315205 creator A5061171292 @default.
- W2594315205 creator A5062165253 @default.
- W2594315205 creator A5071129667 @default.
- W2594315205 creator A5076815130 @default.
- W2594315205 creator A5078494019 @default.
- W2594315205 creator A5087582370 @default.
- W2594315205 date "2017-03-07" @default.
- W2594315205 modified "2023-09-27" @default.
- W2594315205 title "Sorting Nexin 9 facilitates podocin endocytosis in the injured podocyte" @default.
- W2594315205 cites W1485982200 @default.
- W2594315205 cites W1564161461 @default.
- W2594315205 cites W1966911466 @default.
- W2594315205 cites W1968323673 @default.
- W2594315205 cites W1969996031 @default.
- W2594315205 cites W1980653333 @default.
- W2594315205 cites W1982361859 @default.
- W2594315205 cites W1985219470 @default.
- W2594315205 cites W1985804361 @default.
- W2594315205 cites W2015120929 @default.
- W2594315205 cites W2022749558 @default.
- W2594315205 cites W2030716084 @default.
- W2594315205 cites W2039404500 @default.
- W2594315205 cites W2039537505 @default.
- W2594315205 cites W2044812044 @default.
- W2594315205 cites W2055100695 @default.
- W2594315205 cites W2055903121 @default.
- W2594315205 cites W2058880763 @default.
- W2594315205 cites W2061980453 @default.
- W2594315205 cites W2062452684 @default.
- W2594315205 cites W2065697919 @default.
- W2594315205 cites W2069684013 @default.
- W2594315205 cites W2073939793 @default.
- W2594315205 cites W2078264101 @default.
- W2594315205 cites W2096672118 @default.
- W2594315205 cites W2100990796 @default.
- W2594315205 cites W2105525777 @default.
- W2594315205 cites W2108586733 @default.
- W2594315205 cites W2110230080 @default.
- W2594315205 cites W2110490604 @default.
- W2594315205 cites W2114746933 @default.
- W2594315205 cites W2114889093 @default.
- W2594315205 cites W2116155412 @default.
- W2594315205 cites W2125663667 @default.
- W2594315205 cites W2130779504 @default.
- W2594315205 cites W2132864654 @default.
- W2594315205 cites W2133992677 @default.
- W2594315205 cites W2136243698 @default.
- W2594315205 cites W2147955626 @default.
- W2594315205 cites W2157963288 @default.
- W2594315205 cites W2164249826 @default.
- W2594315205 cites W2164934883 @default.
- W2594315205 cites W2167841885 @default.
- W2594315205 cites W2168450345 @default.
- W2594315205 cites W2174311642 @default.
- W2594315205 cites W2276198961 @default.
- W2594315205 cites W2282703745 @default.
- W2594315205 cites W2436991393 @default.
- W2594315205 cites W4231951653 @default.
- W2594315205 cites W4235200559 @default.
- W2594315205 cites W4243856904 @default.
- W2594315205 doi "https://doi.org/10.1038/srep43921" @default.
- W2594315205 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5339724" @default.
- W2594315205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28266622" @default.
- W2594315205 hasPublicationYear "2017" @default.
- W2594315205 type Work @default.
- W2594315205 sameAs 2594315205 @default.
- W2594315205 citedByCount "7" @default.
- W2594315205 countsByYear W25943152052018 @default.
- W2594315205 countsByYear W25943152052020 @default.
- W2594315205 countsByYear W25943152052021 @default.
- W2594315205 countsByYear W25943152052022 @default.
- W2594315205 countsByYear W25943152052023 @default.
- W2594315205 crossrefType "journal-article" @default.
- W2594315205 hasAuthorship W2594315205A5012874068 @default.
- W2594315205 hasAuthorship W2594315205A5020010316 @default.
- W2594315205 hasAuthorship W2594315205A5025616849 @default.
- W2594315205 hasAuthorship W2594315205A5037618983 @default.
- W2594315205 hasAuthorship W2594315205A5038076129 @default.
- W2594315205 hasAuthorship W2594315205A5040361880 @default.
- W2594315205 hasAuthorship W2594315205A5061171292 @default.
- W2594315205 hasAuthorship W2594315205A5062165253 @default.
- W2594315205 hasAuthorship W2594315205A5071129667 @default.
- W2594315205 hasAuthorship W2594315205A5076815130 @default.
- W2594315205 hasAuthorship W2594315205A5078494019 @default.
- W2594315205 hasAuthorship W2594315205A5087582370 @default.
- W2594315205 hasBestOaLocation W25943152051 @default.
- W2594315205 hasConcept C102747710 @default.
- W2594315205 hasConcept C126322002 @default.
- W2594315205 hasConcept C134018914 @default.
- W2594315205 hasConcept C142724271 @default.
- W2594315205 hasConcept C170493617 @default.
- W2594315205 hasConcept C2776855237 @default.