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- W2594440343 abstract "Multicellular development in Dictyostelium discoideum involves tightly regulated signaling events controlling the entry into development, initiation of aggregation and chemotaxis, and cellular differentiation. Here we show that PkcA, a Dictyostelium discoideum Protein Kinase C-orthologue, is involved in quorum sensing and the initiation of development, as well as cAMP sensing during chemotaxis. Additionally, by epistasis analysis we provide evidence that PkcA and PldB (a Phospholipase D-orthologue) functionally interact to regulate aggregation, differentiation, and cell-cell adhesion during development. Finally, we show that PkcA acts as a positive regulator of intracellular PLD-activity during development. Taken together, our results suggest that PkcA act through PldB, by regulating PLD-activity, in order to control events during development." @default.
- W2594440343 created "2017-03-16" @default.
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- W2594440343 date "2017-06-01" @default.
- W2594440343 modified "2023-09-26" @default.
- W2594440343 title "Functional interaction of PkcA and PldB regulate aggregation and development in Dictyostelium discoideum" @default.
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- W2594440343 doi "https://doi.org/10.1016/j.cellsig.2017.02.022" @default.
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