Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594444174> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2594444174 abstract "e15108 Background: Targeted therapy of HER2 overexpression in patients with esophagogastric adenocarcinoma (EGA) improves survival; however, the effect is transient due to the development of resistance. Targeting of EGFR alone in EGA was not active. cMet overexpression is suggested to be a possible resistance pathway for EGFR and HER-2 inhibition. We characterized the expression profile of the EGFR family of receptors and cMet as well as their prognostic significance in EGA. Methods: This retrospective analysis included all patients (pts) with EGA who underwent primary resection at the University of Florida from 2001 to 2011 without neoadjuvant therapy. Demographics, risk factors, tumor features, and outcome data were analyzed. Central blinded immunohistochemistry (IHC) was performed on paraffin embedded tumor specimens with EGFR, HER2, HER3, HER4 and cMet expression scored as low (0, 1+) or high expression (2+, 3+). Descriptive statistics, Fisher exact test, Cox regression and Kaplan-Meier methods were used for statistical analyses. Results: 52 pts (42 M/10 F) were analyzed with median age 66 years (37-83). Most tumors (58%) were stage I (T1N0). Receptors expression profiles and their associations are presented in the Table. High HER3-HER4 co-expression was found in 35% of cases (p = 0.002). Univariate analysis did not show significant correlation of age, tumor differentiation, BMI, tobacco use and receptor expression with survival. Stage was the only variable that correlated significantly with survival (p=0.02). Conclusions: This is the first study to our knowledge examining the EGFR family expression relationships and cMet in treatment naïve resected EGA tumors. Associations between receptor expression patterns are of clinical interest for rational development of multi-targeted inhibition. Although our data do not significantly show receptor status as a prognostic factor, some receptor expression associations suggest trends towards worse survival. Larger studies are warranted for further investigation. [Table: see text]" @default.
- W2594444174 created "2017-03-16" @default.
- W2594444174 creator A5004700748 @default.
- W2594444174 creator A5005221044 @default.
- W2594444174 creator A5009620190 @default.
- W2594444174 creator A5020154592 @default.
- W2594444174 creator A5083129512 @default.
- W2594444174 creator A5083228573 @default.
- W2594444174 creator A5090416642 @default.
- W2594444174 date "2013-05-20" @default.
- W2594444174 modified "2023-09-26" @default.
- W2594444174 title "EGFR family and c-Met expression profiles and prognostic significance in esophagogastric adenocarcinoma." @default.
- W2594444174 doi "https://doi.org/10.1200/jco.2013.31.15_suppl.e15108" @default.
- W2594444174 hasPublicationYear "2013" @default.
- W2594444174 type Work @default.
- W2594444174 sameAs 2594444174 @default.
- W2594444174 citedByCount "0" @default.
- W2594444174 crossrefType "journal-article" @default.
- W2594444174 hasAuthorship W2594444174A5004700748 @default.
- W2594444174 hasAuthorship W2594444174A5005221044 @default.
- W2594444174 hasAuthorship W2594444174A5009620190 @default.
- W2594444174 hasAuthorship W2594444174A5020154592 @default.
- W2594444174 hasAuthorship W2594444174A5083129512 @default.
- W2594444174 hasAuthorship W2594444174A5083228573 @default.
- W2594444174 hasAuthorship W2594444174A5090416642 @default.
- W2594444174 hasConcept C121608353 @default.
- W2594444174 hasConcept C126322002 @default.
- W2594444174 hasConcept C143998085 @default.
- W2594444174 hasConcept C170493617 @default.
- W2594444174 hasConcept C2776996007 @default.
- W2594444174 hasConcept C2780467284 @default.
- W2594444174 hasConcept C2781182431 @default.
- W2594444174 hasConcept C3019338163 @default.
- W2594444174 hasConcept C502942594 @default.
- W2594444174 hasConcept C71924100 @default.
- W2594444174 hasConceptScore W2594444174C121608353 @default.
- W2594444174 hasConceptScore W2594444174C126322002 @default.
- W2594444174 hasConceptScore W2594444174C143998085 @default.
- W2594444174 hasConceptScore W2594444174C170493617 @default.
- W2594444174 hasConceptScore W2594444174C2776996007 @default.
- W2594444174 hasConceptScore W2594444174C2780467284 @default.
- W2594444174 hasConceptScore W2594444174C2781182431 @default.
- W2594444174 hasConceptScore W2594444174C3019338163 @default.
- W2594444174 hasConceptScore W2594444174C502942594 @default.
- W2594444174 hasConceptScore W2594444174C71924100 @default.
- W2594444174 hasLocation W25944441741 @default.
- W2594444174 hasOpenAccess W2594444174 @default.
- W2594444174 hasPrimaryLocation W25944441741 @default.
- W2594444174 hasRelatedWork W1974842472 @default.
- W2594444174 hasRelatedWork W1980223409 @default.
- W2594444174 hasRelatedWork W2044414123 @default.
- W2594444174 hasRelatedWork W2059891247 @default.
- W2594444174 hasRelatedWork W2101088933 @default.
- W2594444174 hasRelatedWork W2111629517 @default.
- W2594444174 hasRelatedWork W2117350088 @default.
- W2594444174 hasRelatedWork W2339899799 @default.
- W2594444174 hasRelatedWork W2351334630 @default.
- W2594444174 hasRelatedWork W2461298495 @default.
- W2594444174 hasRelatedWork W2476167802 @default.
- W2594444174 hasRelatedWork W2486351647 @default.
- W2594444174 hasRelatedWork W2590131123 @default.
- W2594444174 hasRelatedWork W2590387990 @default.
- W2594444174 hasRelatedWork W2590452254 @default.
- W2594444174 hasRelatedWork W2791059251 @default.
- W2594444174 hasRelatedWork W2906751866 @default.
- W2594444174 hasRelatedWork W2938493431 @default.
- W2594444174 hasRelatedWork W3049121642 @default.
- W2594444174 hasRelatedWork W3190444700 @default.
- W2594444174 isParatext "false" @default.
- W2594444174 isRetracted "false" @default.
- W2594444174 magId "2594444174" @default.
- W2594444174 workType "article" @default.