Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594460031> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2594460031 abstract "Genome-wide association studies (GWAS) and next-generation sequencing (NGS) has led to an increase in information about the human genome and cardiovascular disease. Understanding the role of genes in cardiac function and pathology requires modeling gene interactions and identification of regulatory genes as part of a gene regulatory network (GRN). Feature selection and data reduction not sufficient and require domain knowledge to deal with large data. We propose three novel innovations in constructing a GRN based on heuristics. A 2D Visualised Co-regulation function. Post-processing to identify gene-gene interactions. Finally a threshold algorithm is applied to identify the hub genes that provide the backbone of the GRN. The 2D Visualized Co-regulation function performed significantly better compared to the Pearson's correlation for measuring pairwise associations (t=3.46, df=5, p=0.018). The F-measure, improved from 0.11 to 0.12. The hub network provided a 60% improvement to that reported in the literature. The performance of the hub network was then also compared against ARACNe and performed significantly better (p=0.024). We conclude that a heuristics approach in developing GRNs has potential to improve our understanding of gene regulation and interaction in diverse biological function and disease." @default.
- W2594460031 created "2017-03-16" @default.
- W2594460031 creator A5028568297 @default.
- W2594460031 creator A5047791912 @default.
- W2594460031 creator A5063406002 @default.
- W2594460031 creator A5080095540 @default.
- W2594460031 date "2016-09-14" @default.
- W2594460031 modified "2023-09-23" @default.
- W2594460031 title "A Heuristic Gene Regulatory Networks Model for Cardiac Function and Pathology" @default.
- W2594460031 cites W1937374553 @default.
- W2594460031 cites W2009027406 @default.
- W2594460031 cites W2010136740 @default.
- W2594460031 cites W2015271344 @default.
- W2594460031 cites W2016474243 @default.
- W2594460031 cites W2036145288 @default.
- W2594460031 cites W2056254608 @default.
- W2594460031 cites W2083618510 @default.
- W2594460031 cites W2126669894 @default.
- W2594460031 cites W2159993062 @default.
- W2594460031 cites W2166267715 @default.
- W2594460031 cites W2167190345 @default.
- W2594460031 cites W2169950095 @default.
- W2594460031 doi "https://doi.org/10.22489/cinc.2016.101-135" @default.
- W2594460031 hasPublicationYear "2016" @default.
- W2594460031 type Work @default.
- W2594460031 sameAs 2594460031 @default.
- W2594460031 citedByCount "1" @default.
- W2594460031 countsByYear W25944600312018 @default.
- W2594460031 crossrefType "proceedings-article" @default.
- W2594460031 hasAuthorship W2594460031A5028568297 @default.
- W2594460031 hasAuthorship W2594460031A5047791912 @default.
- W2594460031 hasAuthorship W2594460031A5063406002 @default.
- W2594460031 hasAuthorship W2594460031A5080095540 @default.
- W2594460031 hasConcept C104317684 @default.
- W2594460031 hasConcept C106208931 @default.
- W2594460031 hasConcept C111919701 @default.
- W2594460031 hasConcept C116834253 @default.
- W2594460031 hasConcept C124101348 @default.
- W2594460031 hasConcept C127705205 @default.
- W2594460031 hasConcept C135763542 @default.
- W2594460031 hasConcept C14036430 @default.
- W2594460031 hasConcept C150194340 @default.
- W2594460031 hasConcept C153209595 @default.
- W2594460031 hasConcept C154945302 @default.
- W2594460031 hasConcept C173801870 @default.
- W2594460031 hasConcept C184898388 @default.
- W2594460031 hasConcept C41008148 @default.
- W2594460031 hasConcept C54355233 @default.
- W2594460031 hasConcept C59822182 @default.
- W2594460031 hasConcept C67339327 @default.
- W2594460031 hasConcept C70721500 @default.
- W2594460031 hasConcept C86803240 @default.
- W2594460031 hasConceptScore W2594460031C104317684 @default.
- W2594460031 hasConceptScore W2594460031C106208931 @default.
- W2594460031 hasConceptScore W2594460031C111919701 @default.
- W2594460031 hasConceptScore W2594460031C116834253 @default.
- W2594460031 hasConceptScore W2594460031C124101348 @default.
- W2594460031 hasConceptScore W2594460031C127705205 @default.
- W2594460031 hasConceptScore W2594460031C135763542 @default.
- W2594460031 hasConceptScore W2594460031C14036430 @default.
- W2594460031 hasConceptScore W2594460031C150194340 @default.
- W2594460031 hasConceptScore W2594460031C153209595 @default.
- W2594460031 hasConceptScore W2594460031C154945302 @default.
- W2594460031 hasConceptScore W2594460031C173801870 @default.
- W2594460031 hasConceptScore W2594460031C184898388 @default.
- W2594460031 hasConceptScore W2594460031C41008148 @default.
- W2594460031 hasConceptScore W2594460031C54355233 @default.
- W2594460031 hasConceptScore W2594460031C59822182 @default.
- W2594460031 hasConceptScore W2594460031C67339327 @default.
- W2594460031 hasConceptScore W2594460031C70721500 @default.
- W2594460031 hasConceptScore W2594460031C86803240 @default.
- W2594460031 hasLocation W25944600311 @default.
- W2594460031 hasOpenAccess W2594460031 @default.
- W2594460031 hasPrimaryLocation W25944600311 @default.
- W2594460031 hasRelatedWork W1556113727 @default.
- W2594460031 hasRelatedWork W1976199261 @default.
- W2594460031 hasRelatedWork W2012500049 @default.
- W2594460031 hasRelatedWork W2064982054 @default.
- W2594460031 hasRelatedWork W2076513103 @default.
- W2594460031 hasRelatedWork W2123969803 @default.
- W2594460031 hasRelatedWork W2128704089 @default.
- W2594460031 hasRelatedWork W2142664740 @default.
- W2594460031 hasRelatedWork W2156421048 @default.
- W2594460031 hasRelatedWork W2465098683 @default.
- W2594460031 hasRelatedWork W2565065834 @default.
- W2594460031 hasRelatedWork W2586478664 @default.
- W2594460031 hasRelatedWork W2602620302 @default.
- W2594460031 hasRelatedWork W2890417315 @default.
- W2594460031 hasRelatedWork W2898942770 @default.
- W2594460031 hasRelatedWork W2904574059 @default.
- W2594460031 hasRelatedWork W2909771700 @default.
- W2594460031 hasRelatedWork W3123383153 @default.
- W2594460031 hasRelatedWork W3163717165 @default.
- W2594460031 hasRelatedWork W3189268428 @default.
- W2594460031 isParatext "false" @default.
- W2594460031 isRetracted "false" @default.
- W2594460031 magId "2594460031" @default.
- W2594460031 workType "article" @default.