Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594496570> ?p ?o ?g. }
- W2594496570 abstract "The heterotrimeric SecYEG complex cooperates with YidC to facilitate membrane protein insertion by an unknown mechanism. Here we show that YidC contacts the interior of the SecY channel resulting in a ligand-activated and voltage-dependent complex with distinct ion channel characteristics. The SecYEG pore diameter decreases from 8 Å to only 5 Å for the YidC-SecYEG pore, indicating a reduction in channel cross-section by YidC intercalation. In the presence of a substrate, YidC relocates to the rim of the pore as indicated by increased pore diameter and loss of YidC crosslinks to the channel interior. Changing the surface charge of the pore by incorporating YidC into the channel wall increases the anion selectivity, and the accompanying change in wall hydrophobicity is liable to alter the partition of helices from the pore into the membrane. This could explain how the exit of transmembrane domains from the SecY channel is facilitated by YidC." @default.
- W2594496570 created "2017-03-16" @default.
- W2594496570 creator A5000946042 @default.
- W2594496570 creator A5009442181 @default.
- W2594496570 creator A5013827334 @default.
- W2594496570 creator A5035934903 @default.
- W2594496570 creator A5038730428 @default.
- W2594496570 creator A5051060098 @default.
- W2594496570 creator A5061034834 @default.
- W2594496570 creator A5070862488 @default.
- W2594496570 creator A5087527556 @default.
- W2594496570 creator A5089825949 @default.
- W2594496570 date "2017-03-07" @default.
- W2594496570 modified "2023-10-11" @default.
- W2594496570 title "YidC and SecYEG form a heterotetrameric protein translocation channel" @default.
- W2594496570 cites W1546001194 @default.
- W2594496570 cites W1584878924 @default.
- W2594496570 cites W1652876740 @default.
- W2594496570 cites W1747708829 @default.
- W2594496570 cites W1895859721 @default.
- W2594496570 cites W1913648471 @default.
- W2594496570 cites W1974389262 @default.
- W2594496570 cites W1975843918 @default.
- W2594496570 cites W1978110792 @default.
- W2594496570 cites W1979649414 @default.
- W2594496570 cites W1983333099 @default.
- W2594496570 cites W1990054050 @default.
- W2594496570 cites W1995146606 @default.
- W2594496570 cites W1996478334 @default.
- W2594496570 cites W2003246957 @default.
- W2594496570 cites W2005500642 @default.
- W2594496570 cites W2009843970 @default.
- W2594496570 cites W2013120996 @default.
- W2594496570 cites W2025859600 @default.
- W2594496570 cites W2025924686 @default.
- W2594496570 cites W2027335569 @default.
- W2594496570 cites W2031224627 @default.
- W2594496570 cites W2033534477 @default.
- W2594496570 cites W2034065930 @default.
- W2594496570 cites W2036237297 @default.
- W2594496570 cites W2036762805 @default.
- W2594496570 cites W2037587917 @default.
- W2594496570 cites W2038486025 @default.
- W2594496570 cites W2039311296 @default.
- W2594496570 cites W2039661444 @default.
- W2594496570 cites W2043651940 @default.
- W2594496570 cites W2048052250 @default.
- W2594496570 cites W2049749552 @default.
- W2594496570 cites W2057832018 @default.
- W2594496570 cites W2062401722 @default.
- W2594496570 cites W2065537479 @default.
- W2594496570 cites W2067217155 @default.
- W2594496570 cites W2067646832 @default.
- W2594496570 cites W2070331860 @default.
- W2594496570 cites W2073726493 @default.
- W2594496570 cites W2079568874 @default.
- W2594496570 cites W2081934821 @default.
- W2594496570 cites W2088909375 @default.
- W2594496570 cites W2088921362 @default.
- W2594496570 cites W2097534440 @default.
- W2594496570 cites W2103541362 @default.
- W2594496570 cites W2115558294 @default.
- W2594496570 cites W2117213358 @default.
- W2594496570 cites W2118016880 @default.
- W2594496570 cites W2119133319 @default.
- W2594496570 cites W2119861313 @default.
- W2594496570 cites W2126106174 @default.
- W2594496570 cites W2132192325 @default.
- W2594496570 cites W2135607443 @default.
- W2594496570 cites W2141735006 @default.
- W2594496570 cites W2147187494 @default.
- W2594496570 cites W2150067070 @default.
- W2594496570 cites W2155930834 @default.
- W2594496570 cites W2162060803 @default.
- W2594496570 cites W2162514321 @default.
- W2594496570 cites W2169336165 @default.
- W2594496570 cites W2171679939 @default.
- W2594496570 cites W2172252505 @default.
- W2594496570 cites W2914041088 @default.
- W2594496570 cites W4242066724 @default.
- W2594496570 doi "https://doi.org/10.1038/s41598-017-00109-8" @default.
- W2594496570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5427846" @default.
- W2594496570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28273911" @default.
- W2594496570 hasPublicationYear "2017" @default.
- W2594496570 type Work @default.
- W2594496570 sameAs 2594496570 @default.
- W2594496570 citedByCount "42" @default.
- W2594496570 countsByYear W25944965702017 @default.
- W2594496570 countsByYear W25944965702018 @default.
- W2594496570 countsByYear W25944965702019 @default.
- W2594496570 countsByYear W25944965702020 @default.
- W2594496570 countsByYear W25944965702021 @default.
- W2594496570 countsByYear W25944965702022 @default.
- W2594496570 countsByYear W25944965702023 @default.
- W2594496570 crossrefType "journal-article" @default.
- W2594496570 hasAuthorship W2594496570A5000946042 @default.
- W2594496570 hasAuthorship W2594496570A5009442181 @default.
- W2594496570 hasAuthorship W2594496570A5013827334 @default.
- W2594496570 hasAuthorship W2594496570A5035934903 @default.
- W2594496570 hasAuthorship W2594496570A5038730428 @default.