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• W2594512546 abstract "Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1." @default.
• W2594512546 created "2017-03-16" @default.
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• W2594512546 date "2017-01-01" @default.
• W2594512546 modified "2023-10-16" @default.
• W2594512546 title "BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage" @default.
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• W2594512546 doi "https://doi.org/10.1155/2017/5094934" @default.
• W2594512546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5352890" @default.
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