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• W2594518074 abstract "Prenatal exposure to infection is a recognized environmental risk factor for neuropsychiatric disorders of developmental origins such as autism or schizophrenia. Experimental work in animals indicates that this link is mediated by maternal immune activation (MIA) involving interactions between cytokine-associated inflammatory events, oxidative stress, and other pathophysiological processes such as hypoferremia and zinc deficiency. Maternal administration of the viral mimic polyriboinosinic-polyribocytidylic acid (poly(I:C)) in mice produces several behavioral phenotypes in adult offspring of relevance to autism spectrum disorder (ASD) and other neurodevelopmental disorders. Here, we investigated whether some of these phenotypes might also present in juveniles. In addition, given the known immunomodulatory and neuroprotective effects of vitamin D, we also investigated whether the co-administration of vitamin D could block MIA-induced ASD-related behaviors. We co-administered the hormonally active form of vitamin D, 1α,25 dihydroxy vitamin D3 (1,25OHD), simultaneously with poly(I:C) and examined (i) social interaction, stereotyped behavior, emotional learning and memory, and innate anxiety-like behavior in juveniles and (ii) the levels of the pro-inflammatory cytokines IL-1β, IL-6 and TNF-α in maternal plasma and fetal brains. We show that like adult offspring that were exposed to MIA, juveniles display similar deficits in social approach behavior. Juvenile MIA offspring also show abnormal stereotyped digging and impaired acquisition and expression of tone-cued fear conditioning. Importantly, our study reveals that prenatal administration of 1,25OHD abolishes all these behavioral deficits in poly(I:C)-treated juveniles. However, prenatal administration of vitamin D had no effect on pro-inflammatory cytokine levels in dams or in fetal brains suggesting the anti-inflammatory actions of vitamin D are not the critical mechanism for its preventive actions in this ASD animal model. This work raises the possibility that early dietary supplementation with vitamin D may open new avenues for a successful attenuation or even prevention of neurodevelopmental disorders following maternal inflammation during pregnancy." @default.
• W2594518074 created "2017-03-16" @default.
• W2594518074 creator A5020348729 @default.
• W2594518074 creator A5032027116 @default.
• W2594518074 creator A5053870539 @default.
• W2594518074 creator A5068277671 @default.
• W2594518074 date "2017-03-07" @default.
• W2594518074 modified "2023-10-01" @default.
• W2594518074 title "Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation" @default.
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• W2594518074 cites W1879435919 @default.
• W2594518074 cites W1967887989 @default.
• W2594518074 cites W1971328735 @default.
• W2594518074 cites W1980812175 @default.
• W2594518074 cites W1982145294 @default.
• W2594518074 cites W1989871271 @default.
• W2594518074 cites W1990999239 @default.
• W2594518074 cites W1996853027 @default.
• W2594518074 cites W2000253046 @default.
• W2594518074 cites W2011183628 @default.
• W2594518074 cites W2021087861 @default.
• W2594518074 cites W2021909736 @default.
• W2594518074 cites W2024028366 @default.
• W2594518074 cites W2030695586 @default.
• W2594518074 cites W2034427457 @default.
• W2594518074 cites W2036977715 @default.
• W2594518074 cites W2038273986 @default.
• W2594518074 cites W2040408325 @default.
• W2594518074 cites W2040789766 @default.
• W2594518074 cites W2041812587 @default.
• W2594518074 cites W2047772327 @default.
• W2594518074 cites W2048843644 @default.
• W2594518074 cites W2053032438 @default.
• W2594518074 cites W2053714798 @default.
• W2594518074 cites W2054843103 @default.
• W2594518074 cites W2055503327 @default.
• W2594518074 cites W2056901364 @default.
• W2594518074 cites W2061748211 @default.
• W2594518074 cites W2062808587 @default.
• W2594518074 cites W2064954878 @default.
• W2594518074 cites W2065774269 @default.
• W2594518074 cites W2065971435 @default.
• W2594518074 cites W2070438913 @default.
• W2594518074 cites W2073480924 @default.
• W2594518074 cites W2076644456 @default.
• W2594518074 cites W2081161499 @default.
• W2594518074 cites W2084331979 @default.
• W2594518074 cites W2084450750 @default.
• W2594518074 cites W2093802594 @default.
• W2594518074 cites W2098277878 @default.
• W2594518074 cites W2100463268 @default.
• W2594518074 cites W2110448592 @default.
• W2594518074 cites W2114935488 @default.
• W2594518074 cites W2124064773 @default.
• W2594518074 cites W2124580054 @default.
• W2594518074 cites W2125531274 @default.
• W2594518074 cites W2130268646 @default.
• W2594518074 cites W2132155262 @default.
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• W2594518074 cites W2135493800 @default.
• W2594518074 cites W2137618875 @default.
• W2594518074 cites W2140201388 @default.
• W2594518074 cites W2141899840 @default.
• W2594518074 cites W2143217444 @default.
• W2594518074 cites W2150135472 @default.
• W2594518074 cites W2152251767 @default.
• W2594518074 cites W2154965665 @default.
• W2594518074 cites W2157243060 @default.
• W2594518074 cites W2157374919 @default.
• W2594518074 cites W2169769576 @default.
• W2594518074 cites W2170260565 @default.
• W2594518074 cites W2190372604 @default.
• W2594518074 cites W2203502040 @default.
• W2594518074 cites W2253802357 @default.
• W2594518074 cites W2270432837 @default.
• W2594518074 cites W2277293158 @default.
• W2594518074 cites W2315874610 @default.
• W2594518074 cites W2324951369 @default.
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• W2594518074 doi "https://doi.org/10.1186/s13229-017-0125-0" @default.
• W2594518074 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5351212" @default.
• W2594518074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28316773" @default.
• W2594518074 hasPublicationYear "2017" @default.
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• W2594518074 hasAuthorship W2594518074A5053870539 @default.
• W2594518074 hasAuthorship W2594518074A5068277671 @default.

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