FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594530061> ?p ?o ?g. }

• W2594530061 endingPage "1620" @default.
• W2594530061 startingPage "1620" @default.
• W2594530061 abstract "Abstract [Objective] Previous studies showed that c-KIT mutation and <3log reduction of minimal residual disease (MRD) were two poor prognostic markers for acute myeloid leukemia (AML) with t(8;21) . However, How to deal with c-KIT- mutated t(8;21)AML patients with >3log reduction of MRD remains undefined. To answer this question, we performed this study. [Methods] The current retrospective study consisted of 70 newly diagnosed patients with c-KIT- mutated t(8;21)AML during July 2005 and March 2016 in Peking University People's Hospital. Induction treatment included standard 3+7' regimen or HAA regimen. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) was recommended to all patients with an available donor after 2-3 cycles of consolidation treatment with high-dose cytarabine(HDAC). Patients without a donor or refusing HSCT received HDAC-based intensive treatment. MRD was determined by RUNX1/RUNX1T1 transcript levels detected by Q-PCR. The last follow-up time was July 2016. [Results] Sixty-nine out of 70 patients achieved complete remission(CR).Two patients relapsed after first cycle of consolidation treatment. There were 60 patients having the results of MRD after 2 cycles of consolidation treatment (Figure 1). Thirty-four patients achieved >3log reduction of RUNX1/RUNX1T1 transcript levels (defined as major molecular remission, MMR). There were 16 and 18 patients finally receiving chemotherapy and allo-HSCT. Twenty-six patients did not achieve MMR, and 12 and 14 patients finally receiving chemotherapy and allo-HSCH, respectively. For patients achieving MMR, the 4-year cumulative incidence of relapse (CIR) and disease-free survival (DFS) were 84.8% vs.6.7% (p<0.001) and 20.6% vs.87.5% (p<0.001) when receiving chemotherapy or allo-HSCT(Figure 2). For patients not achieving MMR, the 4-year CIR and DFS were 100% vs.30.8% (p<0.001) and 0% vs.60% (p<0.001) when receiving chemotherapy or allo-HSCT (Figure 2). Multivariate analysis revealed that MRD status (MMR or non-MMR and treatment choice (HSCT or chemotherapy) were independent prognostic factors for relapse, DFS. [Conclusion] We concluded that c-KIT- mutated t(8;21)AML patients with >3log reduction of MRD conferred a very high relapse and need allo-HSCT to improve outcome. Figure 1 The flowchart of the study. Figure 1. The flowchart of the study. Figure 2 Thecumulative incidence of relapse (CIR) and disease-free survival (DFS) of c-KIT mutated t(8;21)AML patients. .. Note : MMR: major molecular remission; CT: chemotherapy. HSCT: hematopoietic stem cell transplantation. Figure 2. Thecumulative incidence of relapse (CIR) and disease-free survival (DFS) of c-KIT mutated t(8;21)AML patients. .. / Note : MMR: major molecular remission; CT: chemotherapy. HSCT: hematopoietic stem cell transplantation. Figure 3 Figure 3. Disclosures No relevant conflicts of interest to declare." @default.
• W2594530061 created "2017-03-16" @default.
• W2594530061 creator A5001717980 @default.
• W2594530061 creator A5010680257 @default.
• W2594530061 creator A5037029781 @default.
• W2594530061 creator A5052596963 @default.
• W2594530061 creator A5061407928 @default.
• W2594530061 creator A5065894155 @default.
• W2594530061 creator A5088917859 @default.
• W2594530061 date "2016-12-02" @default.
• W2594530061 modified "2023-09-26" @default.
• W2594530061 title "C-KIT- Mutated t(8;21)AML Patients with >3log Reduction of MRD Conferred a Very High Relapse and Need HSCT to Improve Outcome" @default.
• W2594530061 doi "https://doi.org/10.1182/blood.v128.22.1620.1620" @default.
• W2594530061 hasPublicationYear "2016" @default.
• W2594530061 type Work @default.
• W2594530061 sameAs 2594530061 @default.
• W2594530061 citedByCount "0" @default.
• W2594530061 crossrefType "journal-article" @default.
• W2594530061 hasAuthorship W2594530061A5001717980 @default.
• W2594530061 hasAuthorship W2594530061A5010680257 @default.
• W2594530061 hasAuthorship W2594530061A5037029781 @default.
• W2594530061 hasAuthorship W2594530061A5052596963 @default.
• W2594530061 hasAuthorship W2594530061A5061407928 @default.
• W2594530061 hasAuthorship W2594530061A5065894155 @default.
• W2594530061 hasAuthorship W2594530061A5088917859 @default.
• W2594530061 hasConcept C126322002 @default.
• W2594530061 hasConcept C141071460 @default.
• W2594530061 hasConcept C143998085 @default.
• W2594530061 hasConcept C2776694085 @default.
• W2594530061 hasConcept C2777408962 @default.
• W2594530061 hasConcept C2778041864 @default.
• W2594530061 hasConcept C2778461978 @default.
• W2594530061 hasConcept C2778729363 @default.
• W2594530061 hasConcept C2779823535 @default.
• W2594530061 hasConcept C2781413609 @default.
• W2594530061 hasConcept C2911091166 @default.
• W2594530061 hasConcept C71924100 @default.
• W2594530061 hasConcept C90924648 @default.
• W2594530061 hasConceptScore W2594530061C126322002 @default.
• W2594530061 hasConceptScore W2594530061C141071460 @default.
• W2594530061 hasConceptScore W2594530061C143998085 @default.
• W2594530061 hasConceptScore W2594530061C2776694085 @default.
• W2594530061 hasConceptScore W2594530061C2777408962 @default.
• W2594530061 hasConceptScore W2594530061C2778041864 @default.
• W2594530061 hasConceptScore W2594530061C2778461978 @default.
• W2594530061 hasConceptScore W2594530061C2778729363 @default.
• W2594530061 hasConceptScore W2594530061C2779823535 @default.
• W2594530061 hasConceptScore W2594530061C2781413609 @default.
• W2594530061 hasConceptScore W2594530061C2911091166 @default.
• W2594530061 hasConceptScore W2594530061C71924100 @default.
• W2594530061 hasConceptScore W2594530061C90924648 @default.
• W2594530061 hasIssue "22" @default.
• W2594530061 hasLocation W25945300611 @default.
• W2594530061 hasOpenAccess W2594530061 @default.
• W2594530061 hasPrimaryLocation W25945300611 @default.
• W2594530061 hasRelatedWork W1969162104 @default.
• W2594530061 hasRelatedWork W2026726934 @default.
• W2594530061 hasRelatedWork W2079966689 @default.
• W2594530061 hasRelatedWork W2193293559 @default.
• W2594530061 hasRelatedWork W2406230970 @default.
• W2594530061 hasRelatedWork W2972387925 @default.
• W2594530061 hasRelatedWork W2998600066 @default.
• W2594530061 hasRelatedWork W3036847912 @default.
• W2594530061 hasRelatedWork W3187767987 @default.
• W2594530061 hasRelatedWork W4308772545 @default.
• W2594530061 hasVolume "128" @default.
• W2594530061 isParatext "false" @default.
• W2594530061 isRetracted "false" @default.
• W2594530061 magId "2594530061" @default.
• W2594530061 workType "article" @default.