Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594567044> ?p ?o ?g. }
- W2594567044 abstract "Abstract Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a series of cellular functions. It has been found that autophagy is closely involved in the physiological process of spermatogenesis and the regulation of sperm survival and motility. However, the role of autophagy in high-fat diet (HFD)-induced impaired spermatogenesis remains unknown. This study was designed to investigate the role of autophagy in HFD-induced spermatogenesis deficiency and employed chloroquine (CQ) to inhibit autophagy and rapamycin (RAP) to induce autophagy. 3-methyladenine (3-MA) and CQ were administered via intratesticular injection in vivo . The effects of CQ and 3-MA on the parameters of spermatozoa co-cultured with palmitic acid (PA) in vitro were also investigated. Human semen samples from obese, subfertile male patients were also collected to examine the level of autophagy. The results suggested that HFD mice subjected to CQ showed improved spermatogenesis. Inhibiting autophagy with CQ improved the decreased fertility of HFD male mice. Moreover, the in vivo and in vitro results indicated that both CQ and 3-MA could suppress the pathological changes in spermatozoa caused by HFD or PA treatment. Additionally, the excessive activation of autophagy was also observed in sperm samples from obese, subfertile male patients." @default.
- W2594567044 created "2017-03-16" @default.
- W2594567044 creator A5056384306 @default.
- W2594567044 creator A5068367269 @default.
- W2594567044 creator A5075430732 @default.
- W2594567044 creator A5079905053 @default.
- W2594567044 creator A5082116190 @default.
- W2594567044 creator A5086664284 @default.
- W2594567044 date "2017-03-09" @default.
- W2594567044 modified "2023-10-16" @default.
- W2594567044 title "Diet-induced obesity impairs spermatogenesis: a potential role for autophagy" @default.
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- W2594567044 doi "https://doi.org/10.1038/srep43475" @default.
- W2594567044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5343591" @default.
- W2594567044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28276438" @default.
- W2594567044 hasPublicationYear "2017" @default.