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- W2594579310 abstract "Scientists have attempted to unravel the mysteries of tumor pathogenesis for over a century. Cytogenetic characterization of solid tumors, however, has lagged significantly behind that of leukemia and lymphoma, primarily because of the feasibility of obtaining tissue and the technical problems associated with culturing them. Fortunately, alterations and adaptations of existing conventional cytogenetic protocols, and the development of molecular cytogenetic techniques, have significantly advanced our knowledge of solid tumor cytogenetics. Human solid tumors represent a diverse group of neoplasms that can arise from various cellular components almost anywhere in the body. More than 100 different diseases have been reported that have little in common biologically except for their hyperproliferative nature, as reflected in their abnormal and uncontrolled cellular growth. In order to accomplish a successful cytogenetic study, it is important to appreciate the tumor type or diagnosis in terms of biology and growth patterns in vivo. Unfortunately for the cytogenetics technologist, tissues often arrive at the clinical laboratory without a diagnosis or with a differential that includes multiple diagnostic possibilities, all with their own optimal culture conditions. In spite of this, being aware of the basic principles will increase the chances of success, which is the subject of Chapter 12, Cytogenetic Methods and Findings in Human Solid Tumors, in the AGT Cytogenetics Laboratory Manual, 4th ed. This chapter will discuss tumor classification, recurrent rearrangements, tumor processing, genetic alterations, and molecular testing, including FISH and RT-PCR (reverse transcriptase polymerase chain reaction). Solid tumor culture and harvests protocols are included with this chapter." @default.
- W2594579310 created "2017-03-16" @default.
- W2594579310 creator A5014862398 @default.
- W2594579310 date "2017-03-04" @default.
- W2594579310 modified "2023-09-23" @default.
- W2594579310 title "Cytogenetic methods and findings in human solid tumors" @default.
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