FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594634125> ?p ?o ?g. }

• W2594634125 endingPage "715" @default.
• W2594634125 startingPage "711" @default.
• W2594634125 abstract "Aim: To investigate the levels of G protein-coupled receptor 55 (GPR55) expression in colonic tissue of inflammatory bowel disease (IBD) patients and healthy controls, and its potential implication in IBD treatment.Methods: Fifty patients were enrolled in our prospective study: n = 21 with Crohn’s disease (CD) and n = 16 with ulcerative colitis (UC); 19 women and 18 men. Control consisted of 13 non-IBD patients. In each subject, two biopsies were taken from different colonic locations. In IBD patients, biopsies both from endoscopically inflamed and non-inflamed areas were drawn and the development of inflammation confirmed in histopathological examination. GPR55 mRNA and protein expression were measured using real-time PCR and Western blot, respectively.Results: GPR55 expression at mRNA and protein level was detected in all samples tested. The level of GPR55 mRNA expression in non-inflamed colonic areas was comparable in all analyzed groups (p = .2438). However, in the inflamed tissues GPR55 mRNA expression was statistically significantly (p < .0001) higher (6.9 fold) in CD patients compared to UC. Moreover, CD patients manifested higher (12.5 fold) GPR55 mRNA expression in inflamed compared with non-inflamed colonic tissues (p < .0001). Although no significant differences were stated, GPR55 protein level tends to decrease in IBD as compared to control.Conclusions: Different patterns of GPR55 expression at mRNA level were observed in IBD patients. We speculate that GPR55 is crucial for the mucosal inflammatory processes in IBD, particularly in CD and its expression may affect disease severity, and response to treatment. The GPR55 receptors may become an attractive target for novel therapeutic strategies in IBD." @default.
• W2594634125 created "2017-03-16" @default.
• W2594634125 creator A5011987258 @default.
• W2594634125 creator A5033126398 @default.
• W2594634125 creator A5052006733 @default.
• W2594634125 creator A5054682822 @default.
• W2594634125 creator A5066609339 @default.
• W2594634125 creator A5067306907 @default.
• W2594634125 creator A5070963991 @default.
• W2594634125 creator A5073711716 @default.
• W2594634125 creator A5075326917 @default.
• W2594634125 date "2017-03-08" @default.
• W2594634125 modified "2023-10-03" @default.
• W2594634125 title "G protein-coupled receptor 55 (GPR55) expresses differently in patients with Crohn’s disease and ulcerative colitis" @default.
• W2594634125 cites W1578252886 @default.
• W2594634125 cites W1819429514 @default.
• W2594634125 cites W1824285398 @default.
• W2594634125 cites W1903263117 @default.
• W2594634125 cites W1970813260 @default.
• W2594634125 cites W1977183929 @default.
• W2594634125 cites W1977997231 @default.
• W2594634125 cites W1990276879 @default.
• W2594634125 cites W1991001962 @default.
• W2594634125 cites W1995552285 @default.
• W2594634125 cites W2009968727 @default.
• W2594634125 cites W2015829020 @default.
• W2594634125 cites W2034048156 @default.
• W2594634125 cites W2078621117 @default.
• W2594634125 cites W2113468310 @default.
• W2594634125 cites W2144797452 @default.
• W2594634125 cites W2145159189 @default.
• W2594634125 cites W2165663650 @default.
• W2594634125 cites W2313415277 @default.
• W2594634125 cites W4234676427 @default.
• W2594634125 cites W4254752226 @default.
• W2594634125 cites W86669022 @default.
• W2594634125 doi "https://doi.org/10.1080/00365521.2017.1298834" @default.
• W2594634125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28272905" @default.
• W2594634125 hasPublicationYear "2017" @default.
• W2594634125 type Work @default.
• W2594634125 sameAs 2594634125 @default.
• W2594634125 citedByCount "12" @default.
• W2594634125 countsByYear W25946341252019 @default.
• W2594634125 countsByYear W25946341252020 @default.
• W2594634125 countsByYear W25946341252021 @default.
• W2594634125 countsByYear W25946341252022 @default.
• W2594634125 countsByYear W25946341252023 @default.
• W2594634125 crossrefType "journal-article" @default.
• W2594634125 hasAuthorship W2594634125A5011987258 @default.
• W2594634125 hasAuthorship W2594634125A5033126398 @default.
• W2594634125 hasAuthorship W2594634125A5052006733 @default.
• W2594634125 hasAuthorship W2594634125A5054682822 @default.
• W2594634125 hasAuthorship W2594634125A5066609339 @default.
• W2594634125 hasAuthorship W2594634125A5067306907 @default.
• W2594634125 hasAuthorship W2594634125A5070963991 @default.
• W2594634125 hasAuthorship W2594634125A5073711716 @default.
• W2594634125 hasAuthorship W2594634125A5075326917 @default.
• W2594634125 hasConcept C104317684 @default.
• W2594634125 hasConcept C105580179 @default.
• W2594634125 hasConcept C126322002 @default.
• W2594634125 hasConcept C142724271 @default.
• W2594634125 hasConcept C170493617 @default.
• W2594634125 hasConcept C203014093 @default.
• W2594634125 hasConcept C2775862500 @default.
• W2594634125 hasConcept C2775934546 @default.
• W2594634125 hasConcept C2776415932 @default.
• W2594634125 hasConcept C2776914184 @default.
• W2594634125 hasConcept C2778260677 @default.
• W2594634125 hasConcept C2779134260 @default.
• W2594634125 hasConcept C2779280984 @default.
• W2594634125 hasConcept C2780479503 @default.
• W2594634125 hasConcept C55493867 @default.
• W2594634125 hasConcept C71924100 @default.
• W2594634125 hasConcept C86803240 @default.
• W2594634125 hasConcept C90924648 @default.
• W2594634125 hasConceptScore W2594634125C104317684 @default.
• W2594634125 hasConceptScore W2594634125C105580179 @default.
• W2594634125 hasConceptScore W2594634125C126322002 @default.
• W2594634125 hasConceptScore W2594634125C142724271 @default.
• W2594634125 hasConceptScore W2594634125C170493617 @default.
• W2594634125 hasConceptScore W2594634125C203014093 @default.
• W2594634125 hasConceptScore W2594634125C2775862500 @default.
• W2594634125 hasConceptScore W2594634125C2775934546 @default.
• W2594634125 hasConceptScore W2594634125C2776415932 @default.
• W2594634125 hasConceptScore W2594634125C2776914184 @default.
• W2594634125 hasConceptScore W2594634125C2778260677 @default.
• W2594634125 hasConceptScore W2594634125C2779134260 @default.
• W2594634125 hasConceptScore W2594634125C2779280984 @default.
• W2594634125 hasConceptScore W2594634125C2780479503 @default.
• W2594634125 hasConceptScore W2594634125C55493867 @default.
• W2594634125 hasConceptScore W2594634125C71924100 @default.
• W2594634125 hasConceptScore W2594634125C86803240 @default.
• W2594634125 hasConceptScore W2594634125C90924648 @default.
• W2594634125 hasFunder F4320323482 @default.
• W2594634125 hasIssue "6-7" @default.
• W2594634125 hasLocation W25946341251 @default.
• W2594634125 hasLocation W25946341252 @default.
• W2594634125 hasOpenAccess W2594634125 @default.

• next