FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594651387> ?p ?o ?g. }

• W2594651387 endingPage "28493" @default.
• W2594651387 startingPage "28481" @default.
• W2594651387 abstract "// Ying-fang Guo 1 , Nian-nian Xu 1 , Weijing Sun 1 , Yifan Zhao 1 , Cheng-ye Li 1 , Meng-yao Guo 1 1 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Correspondence to: Meng-yao Guo, email: gmy1985@163.com Keywords: luteolin, mastitis, Staphylococcus aureus (S. aureus), anti-inflammation, inflammatory signal pathway Received: February 01, 2017      Accepted: March 02, 2017      Published: March 10, 2017 ABSTRACT Mastitis is a serious and prevalent disease caused by infection by pathogens such as Staphylococcus aureus . We evaluated the anti-inflammatory effects and mechanism of luteolin, a natural flavonoid with a wide range of pharmacological activities, in a mouse model of S. aureus mastitis. We also treated cultured mouse mammary epithelial cells (mMECs) with S. aureus and luteolin. Histopathological changes were examined by H&E staining and the levels of inflammatory cytokine proteins were analyzed using ELISAs. We determined mRNA levels with qPCR and the level of NF-κB and matrix metalloproteinase (MMP) proteins by Western blotting. The observed histopathological changes showed that luteolin protected mammary glands with S. aureus infection from tissue destruction and inflammatory cell infiltration. Luteolin inhibited the expression of TNF-α, IL-1β, and IL-6, all of which were increased with S. aureus infection of mammary tissues and mMECs. S. aureus -induced TLR2 and TLR4 was suppressed by luteolin, as were levels of IκBα and NF-κB p65 phosphorylation and expression of MMP-2 and MMP-9. Levels of tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 were enhanced. These findings suggest luteolin is a potentially effective new treatment to reduce tissue damage and inflammation from S. aureus -induced mastitis." @default.
• W2594651387 created "2017-03-16" @default.
• W2594651387 creator A5019734570 @default.
• W2594651387 creator A5023110743 @default.
• W2594651387 creator A5035532552 @default.
• W2594651387 creator A5038658584 @default.
• W2594651387 creator A5045070647 @default.
• W2594651387 creator A5051741885 @default.
• W2594651387 date "2017-03-10" @default.
• W2594651387 modified "2023-10-01" @default.
• W2594651387 title "Luteolin reduces inflammation in<i>Staphylococcus aureus</i>-induced mastitis by inhibiting NF-κB activation and MMPs expression" @default.
• W2594651387 cites W111660488 @default.
• W2594651387 cites W148052990 @default.
• W2594651387 cites W1484597289 @default.
• W2594651387 cites W1664158328 @default.
• W2594651387 cites W1669188803 @default.
• W2594651387 cites W173128540 @default.
• W2594651387 cites W1979096652 @default.
• W2594651387 cites W19826679 @default.
• W2594651387 cites W1987781980 @default.
• W2594651387 cites W1988652043 @default.
• W2594651387 cites W1992779539 @default.
• W2594651387 cites W1995976009 @default.
• W2594651387 cites W2000813386 @default.
• W2594651387 cites W2004149652 @default.
• W2594651387 cites W2004773897 @default.
• W2594651387 cites W2008081537 @default.
• W2594651387 cites W2008281819 @default.
• W2594651387 cites W2010807769 @default.
• W2594651387 cites W2012310912 @default.
• W2594651387 cites W2022211106 @default.
• W2594651387 cites W2022676743 @default.
• W2594651387 cites W2025449580 @default.
• W2594651387 cites W2027830774 @default.
• W2594651387 cites W2028195000 @default.
• W2594651387 cites W2037252842 @default.
• W2594651387 cites W2040647275 @default.
• W2594651387 cites W2041253490 @default.
• W2594651387 cites W2046575929 @default.
• W2594651387 cites W2047987364 @default.
• W2594651387 cites W2048636094 @default.
• W2594651387 cites W2052435675 @default.
• W2594651387 cites W2053314848 @default.
• W2594651387 cites W2059790490 @default.
• W2594651387 cites W2061198612 @default.
• W2594651387 cites W2073882423 @default.
• W2594651387 cites W2082426484 @default.
• W2594651387 cites W2092781343 @default.
• W2594651387 cites W2094863064 @default.
• W2594651387 cites W2097991167 @default.
• W2594651387 cites W2107337395 @default.
• W2594651387 cites W2113749884 @default.
• W2594651387 cites W2114132866 @default.
• W2594651387 cites W2115111673 @default.
• W2594651387 cites W2122044177 @default.
• W2594651387 cites W2137063490 @default.
• W2594651387 cites W2147978858 @default.
• W2594651387 cites W2163831264 @default.
• W2594651387 cites W2313869283 @default.
• W2594651387 cites W4250908540 @default.
• W2594651387 doi "https://doi.org/10.18632/oncotarget.16092" @default.
• W2594651387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5438666" @default.
• W2594651387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28415707" @default.
• W2594651387 hasPublicationYear "2017" @default.
• W2594651387 type Work @default.
• W2594651387 sameAs 2594651387 @default.
• W2594651387 citedByCount "47" @default.
• W2594651387 countsByYear W25946513872017 @default.
• W2594651387 countsByYear W25946513872018 @default.
• W2594651387 countsByYear W25946513872019 @default.
• W2594651387 countsByYear W25946513872020 @default.
• W2594651387 countsByYear W25946513872021 @default.
• W2594651387 countsByYear W25946513872022 @default.
• W2594651387 countsByYear W25946513872023 @default.
• W2594651387 crossrefType "journal-article" @default.
• W2594651387 hasAuthorship W2594651387A5019734570 @default.
• W2594651387 hasAuthorship W2594651387A5023110743 @default.
• W2594651387 hasAuthorship W2594651387A5035532552 @default.
• W2594651387 hasAuthorship W2594651387A5038658584 @default.
• W2594651387 hasAuthorship W2594651387A5045070647 @default.
• W2594651387 hasAuthorship W2594651387A5051741885 @default.
• W2594651387 hasBestOaLocation W25946513871 @default.
• W2594651387 hasConcept C142724271 @default.
• W2594651387 hasConcept C203014093 @default.
• W2594651387 hasConcept C2776070231 @default.
• W2594651387 hasConcept C2776080593 @default.
• W2594651387 hasConcept C2776344049 @default.
• W2594651387 hasConcept C2776914184 @default.
• W2594651387 hasConcept C2778004101 @default.
• W2594651387 hasConcept C2779054382 @default.
• W2594651387 hasConcept C2779489039 @default.
• W2594651387 hasConcept C2781236682 @default.
• W2594651387 hasConcept C523546767 @default.
• W2594651387 hasConcept C54355233 @default.
• W2594651387 hasConcept C55493867 @default.
• W2594651387 hasConcept C556039675 @default.
• W2594651387 hasConcept C71924100 @default.
• W2594651387 hasConcept C86803240 @default.

• next