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- W2594653735 abstract "Besides inactivating tumour suppressor activity in cells, mutations in p53 confer significant oncogenic functions and promote metastasis and resistance to anticancer therapy. A variety of therapies involving genetic and epigenetic signalling events regulate tumorogenesis and progression in such cases. Pharmacological interventions with HDAC inhibitors have shown promise in therapy. This work explores the changes in efficacy of the four HDAC inhibitors SAHA, MS-275, valproic acid and sodium butyrate on a panel of colon cancer cell lines – HCT116 (p53 wt), HCT116 p53-/-, HT29 and SW480 (with mutations in p53). Clonogenic assays, gene profiling and epigenetic expression done on these cells point to p53 dependent differential activity of the 4 HDAC inhibitors which also elevate methylation levels in p53 mutant cell lines. In silico modelling establishes the alterations in interactions that lead to such differential activity of valproic acid, one of the inhibitors considered for the work. Molecular Dynamic simulations carried out on the valproic acid complex ensure stability of the complex. This work establishes a p53 dependent epigenetic signalling mechanism triggered by HDAC inhibition expanding the scope of HDAC inhibitors in adjuvant therapy for p53 mutant tumours." @default.
- W2594653735 created "2017-03-16" @default.
- W2594653735 creator A5051461795 @default.
- W2594653735 creator A5052580092 @default.
- W2594653735 date "2017-03-28" @default.
- W2594653735 modified "2023-10-10" @default.
- W2594653735 title "HDAC inhibitors show differential epigenetic regulation and cell survival strategies on p53 mutant colon cancer cells" @default.
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- W2594653735 cites W1886063157 @default.
- W2594653735 cites W1890805542 @default.
- W2594653735 cites W1928327536 @default.
- W2594653735 cites W1957739110 @default.
- W2594653735 cites W1965086052 @default.
- W2594653735 cites W1966018333 @default.
- W2594653735 cites W1977068148 @default.
- W2594653735 cites W1979180093 @default.
- W2594653735 cites W1984207046 @default.
- W2594653735 cites W1987172374 @default.
- W2594653735 cites W1987517037 @default.
- W2594653735 cites W1995049733 @default.
- W2594653735 cites W1995068068 @default.
- W2594653735 cites W2010875436 @default.
- W2594653735 cites W2011660168 @default.
- W2594653735 cites W2013305519 @default.
- W2594653735 cites W2015386588 @default.
- W2594653735 cites W2016724097 @default.
- W2594653735 cites W2020430786 @default.
- W2594653735 cites W2024143289 @default.
- W2594653735 cites W2025429202 @default.
- W2594653735 cites W2027171343 @default.
- W2594653735 cites W2030217455 @default.
- W2594653735 cites W2034010972 @default.
- W2594653735 cites W2035569661 @default.
- W2594653735 cites W2041387751 @default.
- W2594653735 cites W2042484101 @default.
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- W2594653735 cites W2069341069 @default.
- W2594653735 cites W2069452349 @default.
- W2594653735 cites W2075514579 @default.
- W2594653735 cites W2085653208 @default.
- W2594653735 cites W2086620037 @default.
- W2594653735 cites W2088010622 @default.
- W2594653735 cites W2088296885 @default.
- W2594653735 cites W2088711557 @default.
- W2594653735 cites W2091487108 @default.
- W2594653735 cites W2099606391 @default.
- W2594653735 cites W2105668062 @default.
- W2594653735 cites W2106900373 @default.
- W2594653735 cites W2108918530 @default.
- W2594653735 cites W2111523470 @default.
- W2594653735 cites W2112257261 @default.
- W2594653735 cites W2112396116 @default.
- W2594653735 cites W2112743424 @default.
- W2594653735 cites W2114455364 @default.
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- W2594653735 cites W2129769331 @default.
- W2594653735 cites W2132629607 @default.
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- W2594653735 cites W2135800465 @default.
- W2594653735 cites W2139505515 @default.
- W2594653735 cites W2146450812 @default.
- W2594653735 cites W2158289038 @default.
- W2594653735 cites W2158747282 @default.
- W2594653735 cites W2160544821 @default.
- W2594653735 cites W2165638033 @default.
- W2594653735 cites W2169908872 @default.
- W2594653735 cites W2170622332 @default.
- W2594653735 cites W2176389780 @default.
- W2594653735 cites W2198705072 @default.
- W2594653735 cites W2258872553 @default.
- W2594653735 cites W2276640786 @default.
- W2594653735 cites W2292287230 @default.
- W2594653735 cites W2409136177 @default.
- W2594653735 cites W2512500289 @default.
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- W2594653735 doi "https://doi.org/10.1080/07391102.2017.1302820" @default.
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- W2594653735 hasPublicationYear "2017" @default.
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