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• W2594684225 abstract "pH responsive polymeric nanoparticles have emerged as a promising technology platform for targeted and controlled drug delivery in recent years. In this paper, endosomal pH-activatable doxorubicin (DOX) and core-crosslinked polymeric nanoparticles (DCNPs) were prepared and investigated for potent growth inhibition of human cancer cells in vitro . In vitro drug release studies, DOX conjugated nanoparticles with hydrazone bond showed a pH sensitive release phenomenon, that is, the releasing is significantly faster at mildly acidic condition with pH of 5.5 than that at physiological condition. Confocal laser scanning microscope (CLSM) observations revealed that DOX conjugated nanoparticles delivered and released DOX into the cytosols as well as cell nuclei of Hela cells following 6 h incubation. MTT assays demonstrated that these pH-sensitive DOX nanoparticles exhibited high antitumor effect to HeLa cells. The conjugated DOX polymeric nanoparticles may be a promising candidate as a nanoscale and pH-sensitive drug delivery vehicle for cancer therapy." @default.
• W2594684225 created "2017-03-16" @default.
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• W2594684225 date "2017-03-01" @default.
• W2594684225 modified "2023-09-27" @default.
• W2594684225 title "A Facile Synthesis of Acid-Activatable Nanoparticles for Efficient Intracellular Doxorubicin Release" @default.
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• W2594684225 doi "https://doi.org/10.4028/www.scientific.net/jnanor.46.20" @default.
• W2594684225 hasPublicationYear "2017" @default.
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