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- W2594726729 abstract "Curcumin (diferuloymethane), a yellow colouring agent present in the rhizome of Curcuma longa Linn (Zingiberaceae), has been reported to possess anti-inflammatory, antioxidant and anticarcinogenic activities. Despite such significant anti-tumor efficacies and bio-safety profiles of curcumin, its poor systemic bioavailability originating from sub-optimal absorption, rapid metabolism and fast systemic elimination, is turning out to be one of the major impeding factors retarding its clinical success. Curcumin exerts its chemoprotective and chemopreventive effects via multiple mechanisms. It has been reported to induce expression of the antioxidant enzymes in various cell lines. Curcumin significantly increased expression of Nrf2 as well as phase II detoxifying and antioxidant enzymes. The redox-sensitive transcription factor, nuclear factor erythroid 2 p45 (NF-E2)-related factor (Nrf2) plays a key role in regulating induction of phase II detoxifying or antioxidant enzymes. Thus, activation of Nrf2 is considered to be an important molecular target of many chemopreventive and chemoprotective agents. This review summarizes the molecular basis of chemoprevention and cytoprotection afforded by curcumin with emphasis on its ability to modulate Nrf2-mediated cellular events. In this review, we describe both antioxidant activity and effects of curcumin on biotransformation enzymes involved in carcinogen metabolism." @default.
- W2594726729 created "2017-03-16" @default.
- W2594726729 creator A5009242331 @default.
- W2594726729 creator A5088886451 @default.
- W2594726729 date "2014-01-01" @default.
- W2594726729 modified "2023-09-25" @default.
- W2594726729 title "A review of antioxidant polyphenol curcumin and its role in detoxification" @default.
- W2594726729 cites W1538056938 @default.
- W2594726729 cites W1560004065 @default.
- W2594726729 cites W1877143754 @default.
- W2594726729 cites W1924592317 @default.
- W2594726729 cites W1929788581 @default.
- W2594726729 cites W1935939906 @default.
- W2594726729 cites W1964726348 @default.
- W2594726729 cites W1969415522 @default.
- W2594726729 cites W1971991198 @default.
- W2594726729 cites W1972179974 @default.
- W2594726729 cites W1972512637 @default.
- W2594726729 cites W1986166053 @default.
- W2594726729 cites W1987837071 @default.
- W2594726729 cites W1988339898 @default.
- W2594726729 cites W1988428430 @default.
- W2594726729 cites W1990483354 @default.
- W2594726729 cites W1993872576 @default.
- W2594726729 cites W1994193544 @default.
- W2594726729 cites W1995043836 @default.
- W2594726729 cites W1997149430 @default.
- W2594726729 cites W2003392863 @default.
- W2594726729 cites W2010073511 @default.
- W2594726729 cites W2010425823 @default.
- W2594726729 cites W2011243629 @default.
- W2594726729 cites W2013628781 @default.
- W2594726729 cites W2013830754 @default.
- W2594726729 cites W2018737017 @default.
- W2594726729 cites W2018935876 @default.
- W2594726729 cites W2020374958 @default.
- W2594726729 cites W2021269411 @default.
- W2594726729 cites W2022941860 @default.
- W2594726729 cites W2023398982 @default.
- W2594726729 cites W2024883650 @default.
- W2594726729 cites W2024960745 @default.
- W2594726729 cites W2028594138 @default.
- W2594726729 cites W2029336804 @default.
- W2594726729 cites W2033431239 @default.
- W2594726729 cites W2038796248 @default.
- W2594726729 cites W2045477799 @default.
- W2594726729 cites W2051796025 @default.
- W2594726729 cites W2055966049 @default.
- W2594726729 cites W2057523433 @default.
- W2594726729 cites W2058331808 @default.
- W2594726729 cites W2058780002 @default.
- W2594726729 cites W2071959081 @default.
- W2594726729 cites W2073374523 @default.
- W2594726729 cites W2073730820 @default.
- W2594726729 cites W2074918879 @default.
- W2594726729 cites W2084780635 @default.
- W2594726729 cites W2088352865 @default.
- W2594726729 cites W2089952442 @default.
- W2594726729 cites W2095624924 @default.
- W2594726729 cites W2095637939 @default.
- W2594726729 cites W2095914657 @default.
- W2594726729 cites W2096997867 @default.
- W2594726729 cites W2101356736 @default.
- W2594726729 cites W2101464901 @default.
- W2594726729 cites W2105282783 @default.
- W2594726729 cites W2113192813 @default.
- W2594726729 cites W2117316894 @default.
- W2594726729 cites W2121166735 @default.
- W2594726729 cites W2124122523 @default.
- W2594726729 cites W2129397604 @default.
- W2594726729 cites W2129884254 @default.
- W2594726729 cites W2131813131 @default.
- W2594726729 cites W2135378360 @default.
- W2594726729 cites W2136818071 @default.
- W2594726729 cites W2138508372 @default.
- W2594726729 cites W2139993130 @default.
- W2594726729 cites W2141116781 @default.
- W2594726729 cites W2154748960 @default.
- W2594726729 cites W2156156861 @default.
- W2594726729 cites W2156896504 @default.
- W2594726729 cites W2160770872 @default.
- W2594726729 cites W2161531885 @default.
- W2594726729 cites W2163290644 @default.
- W2594726729 cites W2164036989 @default.
- W2594726729 cites W2171748567 @default.
- W2594726729 cites W2182889158 @default.
- W2594726729 cites W2184338251 @default.
- W2594726729 cites W2187456576 @default.
- W2594726729 cites W2189011617 @default.
- W2594726729 cites W2238003553 @default.
- W2594726729 cites W2323821902 @default.
- W2594726729 cites W2410304359 @default.
- W2594726729 cites W646356056 @default.
- W2594726729 cites W74993898 @default.
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