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- W2594868051 abstract "2571 Background: Tracking adoptively transfered cells is an essential prerequisite for devising better protocols for cellular therapy. Thus, a highly sensitive method for non-invasive visualization of labeled lymphocytes in vivo by combined PET and magnetic resonance imaging (MRI) has been developed and applied for tracking adoptively transfered tumor-specific T cells in a mouse model system. Methods: C57BL/6J mice carrying subcutaneous tumors of the ovalbumin (OVA)-expressing malignant melanoma cell line B16-OVA were adoptively transfered with OVA-specific CD8+ T cells labeled with 124-iodine-conjugated deoxyuridine (124-IdU). Five days after transfer of T cells, mice were killed and subjected to PET and MR imaging. Using a newly developed method for co-registration of the two image modalities, the anatomical localization of the transfered cells was visualized and the amount of radioactivity in various anatomical locations were very accurately determined. Results: Results showed a clear homing of the tra..." @default.
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- W2594868051 date "2004-07-15" @default.
- W2594868051 modified "2023-09-27" @default.
- W2594868051 title "Monitoring in vivo T cell traficking to tumors by positron emission tomography and magnetic resonance imaging" @default.
- W2594868051 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.2571" @default.
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