Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594889413> ?p ?o ?g. }
- W2594889413 endingPage "2015" @default.
- W2594889413 startingPage "2007" @default.
- W2594889413 abstract "Due to the anti-proliferative and anti-apoptotic effects of retinoic acid (RA), this hormone has emerged as a target for several diseases, including cancer. However, development of retinoid resistance is a critical issue and efforts to understand the retinoid signaling pathway may identify useful biomarkers for future clinical trials. Apoptotic responses of RA are exhibited through the cellular RA-binding protein II (CRABPII)/retinoic acid receptor (RAR) signaling cascade. Delivery of RA to RAR by CRABPII enhances the transcriptional activity of genes involved in cell death and cell cycle arrest. The purpose of this study was to investigate the role of curcumin in sensitizing RA-resistant triple-negative breast cancer (TNBC) cells to RA-mediated apoptosis. We provide evidence that curcumin upregulates the expression of CRABPII, RARβ and RARγ in two different TNBC cell lines. Co-treatment of the cells with curcumin and RA results in increased apoptosis as demonstrated by elevated cleavage of poly(ADP-ribose) polymerase and cleaved caspase-9. Additionally, silencing CRABPII reverses curcumin sensitization of TNBC cells to the apoptotic inducing effects of RA. These findings provide mechanistic insights into sensitizing TNBC cells to RA-mediated cell death by curcumin-induced upregulation of the CRABPII/RAR pathway." @default.
- W2594889413 created "2017-03-16" @default.
- W2594889413 creator A5028512662 @default.
- W2594889413 creator A5030931892 @default.
- W2594889413 creator A5037121025 @default.
- W2594889413 creator A5071685272 @default.
- W2594889413 creator A5078199692 @default.
- W2594889413 date "2017-03-01" @default.
- W2594889413 modified "2023-10-10" @default.
- W2594889413 title "Activation of the CRABPII/RAR pathway by curcumin induces retinoic acid mediated apoptosis in retinoic acid resistant breast cancer cells" @default.
- W2594889413 cites W1130577162 @default.
- W2594889413 cites W1484870202 @default.
- W2594889413 cites W1551972473 @default.
- W2594889413 cites W1594207405 @default.
- W2594889413 cites W1774777288 @default.
- W2594889413 cites W1781127799 @default.
- W2594889413 cites W1904095165 @default.
- W2594889413 cites W1927684145 @default.
- W2594889413 cites W1966059799 @default.
- W2594889413 cites W1972062117 @default.
- W2594889413 cites W1977920395 @default.
- W2594889413 cites W1978440962 @default.
- W2594889413 cites W1979209078 @default.
- W2594889413 cites W1986591639 @default.
- W2594889413 cites W1989252518 @default.
- W2594889413 cites W1991178530 @default.
- W2594889413 cites W2003318378 @default.
- W2594889413 cites W2009063293 @default.
- W2594889413 cites W2018902607 @default.
- W2594889413 cites W2031201349 @default.
- W2594889413 cites W2034455812 @default.
- W2594889413 cites W2036594769 @default.
- W2594889413 cites W2044640605 @default.
- W2594889413 cites W2047145360 @default.
- W2594889413 cites W2055043067 @default.
- W2594889413 cites W2062256791 @default.
- W2594889413 cites W2064402415 @default.
- W2594889413 cites W2064708887 @default.
- W2594889413 cites W2077872976 @default.
- W2594889413 cites W2090314916 @default.
- W2594889413 cites W2093995222 @default.
- W2594889413 cites W2096098783 @default.
- W2594889413 cites W2106042136 @default.
- W2594889413 cites W2107037828 @default.
- W2594889413 cites W2107277218 @default.
- W2594889413 cites W2114756892 @default.
- W2594889413 cites W2115727543 @default.
- W2594889413 cites W2116071221 @default.
- W2594889413 cites W2122808667 @default.
- W2594889413 cites W2129338773 @default.
- W2594889413 cites W2129884254 @default.
- W2594889413 cites W2133260121 @default.
- W2594889413 cites W2135871242 @default.
- W2594889413 cites W2149566991 @default.
- W2594889413 cites W2164721789 @default.
- W2594889413 cites W2165884519 @default.
- W2594889413 cites W2167639932 @default.
- W2594889413 cites W2170759963 @default.
- W2594889413 cites W2172024684 @default.
- W2594889413 cites W2172184136 @default.
- W2594889413 cites W2187456576 @default.
- W2594889413 cites W2189105333 @default.
- W2594889413 cites W2190337443 @default.
- W2594889413 cites W2192080449 @default.
- W2594889413 cites W2289129640 @default.
- W2594889413 cites W2289693384 @default.
- W2594889413 cites W2310180628 @default.
- W2594889413 cites W2341020835 @default.
- W2594889413 cites W2399528765 @default.
- W2594889413 cites W2464824256 @default.
- W2594889413 cites W2474937375 @default.
- W2594889413 cites W2482793089 @default.
- W2594889413 doi "https://doi.org/10.3892/or.2017.5495" @default.
- W2594889413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5367344" @default.
- W2594889413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28350049" @default.
- W2594889413 hasPublicationYear "2017" @default.
- W2594889413 type Work @default.
- W2594889413 sameAs 2594889413 @default.
- W2594889413 citedByCount "11" @default.
- W2594889413 countsByYear W25948894132018 @default.
- W2594889413 countsByYear W25948894132019 @default.
- W2594889413 countsByYear W25948894132020 @default.
- W2594889413 countsByYear W25948894132021 @default.
- W2594889413 countsByYear W25948894132022 @default.
- W2594889413 crossrefType "journal-article" @default.
- W2594889413 hasAuthorship W2594889413A5028512662 @default.
- W2594889413 hasAuthorship W2594889413A5030931892 @default.
- W2594889413 hasAuthorship W2594889413A5037121025 @default.
- W2594889413 hasAuthorship W2594889413A5071685272 @default.
- W2594889413 hasAuthorship W2594889413A5078199692 @default.
- W2594889413 hasBestOaLocation W25948894131 @default.
- W2594889413 hasConcept C104317684 @default.
- W2594889413 hasConcept C119056186 @default.
- W2594889413 hasConcept C120197328 @default.
- W2594889413 hasConcept C121608353 @default.
- W2594889413 hasConcept C127561419 @default.
- W2594889413 hasConcept C185592680 @default.
- W2594889413 hasConcept C190283241 @default.