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• W2594906385 abstract "Ellagic acid (EA), a natural polyphenol evidence several pharmacological benefits. The binding profile of EA with human serum albumin (HSA) has been explored and investigated by Isothermal titration calorimetry (ITC), circular dichroism (CD) spectroscopy, time-correlated single-photon counting (TCSPC), absorbance spectroscopy, steady-state fluorescence spectroscopy, and modelling studies. The ITC data analysis revealed the binding Constant (Ka), ΔH, ΔS and ΔG values to be 15.5×104M−1, −116.2±18.1 Kcal mol−1, −366 cal mol−1K−1 and −7.13 Kcal mol−1 respectively with a unique binding site at HSA. EA effectively quenched the intrinsic fluorescence of HSA by static quenching, whereas TCSPC data also revealed association of dynamic quenching also. Thermodynamic analysis confirmed that hydrophobic and mainly hydrogen bonding interaction played important role in stabilizing the HSA-EA complex. It further dictates the binding reaction to be enthalpy driven. The secondary structure of HSA was altered upon binding with EA. CD spectroscopic data indicated the fraction of alpha helicity to be decreased from 52% to 40% upon binding to EA. This study will provide an insight on evaluation of this bioactive interaction during transport and releasing efficiency at the target site in human physiological system since HSA is the most important carrier protein in blood serum." @default.
• W2594906385 created "2017-03-16" @default.
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• W2594906385 date "2017-07-01" @default.
• W2594906385 modified "2023-10-18" @default.
• W2594906385 title "An insight to the binding of ellagic acid with human serum albumin using spectroscopic and isothermal calorimetry studies" @default.
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• W2594906385 doi "https://doi.org/10.1016/j.bbrep.2017.03.001" @default.
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