Matches in SemOpenAlex for { <https://semopenalex.org/work/W2594906900> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2594906900 abstract "Somatostatin-containing neurons have a widespread distribution in the central nervous system. Moreover, the level of somatostatin in bloody cerebrospinal fluid and plasma is elevated patients with stroke. However, there is little evidence to support that somatostatin is a possible factor of vasopasm after stroke. This experiment was to undertaken to evaluate the effects of somatostatin on Ca 2+ currents using the whole-cell voltage-clamp techniques and on Ca 2+ transients using whole-cell fluorescence in cerebral arteries of the rabbit. During rectangular pulses, both peak and steady-state Ca 2+ currents were significantly increased by the application of somatostatin. Somatostatin had little effect on the steady-state activation kinetics, however, significant effect on the time constants for current decay. τ increased monotonically with voltage and was slightly slower in somatostatin-treated cells between 0 and +30 mV. The half maximal concentration of somatostatin was 8.5±1.3 pM in dose-response relation. Moreover, Ca 2+ transients by somatostatin were significantly increased in cells. From these results, the activation of Ca 2+ currents by somatostatin could be involved in pathogenesis of vasospasm after stroke." @default.
- W2594906900 created "2017-03-16" @default.
- W2594906900 creator A5005873228 @default.
- W2594906900 creator A5013079349 @default.
- W2594906900 creator A5018157819 @default.
- W2594906900 creator A5062719341 @default.
- W2594906900 date "2012-05-01" @default.
- W2594906900 modified "2023-09-26" @default.
- W2594906900 title "Abstract 472: Calcium Current by Somatostatin Leads to Vasoconstriction in Rabbit Cerebral Artery" @default.
- W2594906900 doi "https://doi.org/10.1161/atvb.32.suppl_1.a472" @default.
- W2594906900 hasPublicationYear "2012" @default.
- W2594906900 type Work @default.
- W2594906900 sameAs 2594906900 @default.
- W2594906900 citedByCount "0" @default.
- W2594906900 crossrefType "journal-article" @default.
- W2594906900 hasAuthorship W2594906900A5005873228 @default.
- W2594906900 hasAuthorship W2594906900A5013079349 @default.
- W2594906900 hasAuthorship W2594906900A5018157819 @default.
- W2594906900 hasAuthorship W2594906900A5062719341 @default.
- W2594906900 hasConcept C126322002 @default.
- W2594906900 hasConcept C134018914 @default.
- W2594906900 hasConcept C185592680 @default.
- W2594906900 hasConcept C2776297358 @default.
- W2594906900 hasConcept C519063684 @default.
- W2594906900 hasConcept C71924100 @default.
- W2594906900 hasConceptScore W2594906900C126322002 @default.
- W2594906900 hasConceptScore W2594906900C134018914 @default.
- W2594906900 hasConceptScore W2594906900C185592680 @default.
- W2594906900 hasConceptScore W2594906900C2776297358 @default.
- W2594906900 hasConceptScore W2594906900C519063684 @default.
- W2594906900 hasConceptScore W2594906900C71924100 @default.
- W2594906900 hasIssue "suppl_1" @default.
- W2594906900 hasLocation W25949069001 @default.
- W2594906900 hasOpenAccess W2594906900 @default.
- W2594906900 hasPrimaryLocation W25949069001 @default.
- W2594906900 hasRelatedWork W1968094290 @default.
- W2594906900 hasRelatedWork W196991818 @default.
- W2594906900 hasRelatedWork W1980114643 @default.
- W2594906900 hasRelatedWork W1994951002 @default.
- W2594906900 hasRelatedWork W1994959197 @default.
- W2594906900 hasRelatedWork W2011585859 @default.
- W2594906900 hasRelatedWork W2021625741 @default.
- W2594906900 hasRelatedWork W2039195345 @default.
- W2594906900 hasRelatedWork W2042963715 @default.
- W2594906900 hasRelatedWork W2071467078 @default.
- W2594906900 hasRelatedWork W2091630314 @default.
- W2594906900 hasRelatedWork W2092460764 @default.
- W2594906900 hasRelatedWork W2095086099 @default.
- W2594906900 hasRelatedWork W2121352744 @default.
- W2594906900 hasRelatedWork W2128153018 @default.
- W2594906900 hasRelatedWork W2149778573 @default.
- W2594906900 hasRelatedWork W2169352888 @default.
- W2594906900 hasRelatedWork W2187910228 @default.
- W2594906900 hasRelatedWork W2262451570 @default.
- W2594906900 hasRelatedWork W89290949 @default.
- W2594906900 hasVolume "32" @default.
- W2594906900 isParatext "false" @default.
- W2594906900 isRetracted "false" @default.
- W2594906900 magId "2594906900" @default.
- W2594906900 workType "article" @default.