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- W2595055509 abstract "P49 Stimulation of vascularβ-adrenoceptors leads to smooth muscle hyperpolarization, presumably through theβ-adrenoceptors/Gs protein/adenylate cyclase/ATP-sensitive K + -channels (KATP) signaling cascade, which has been shown to play an important role in the sympathetic control of membrane potential. Impairedβ-adrenoceptor-mediated hyperpolarization has been reported in established stage of hypertension in rat models. However, it is not known whether such an abnormality exists in prehypertensive stage. To clarify this point, we comparedβ-adrenoceptor-mediated hyperpolarization using microelectrodes in mesenteric resistance arteries from 5-week-old, prehypertensive spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats (WKY). Systolic blood pressure did not differ between these rats (137.5±4.3 vs. 138.1±2.3mmHg; P=ns, n=10). Isoproterenol-induced hyperpolarization was significantly less in prehypertensive SHR than in WKY (10 -7 mol/L; -4.6±0.6 vs. -7.8±0.8mV; P -6 mol/L; -7.8±0.5 vs. -9.8±0.6mV; P -6 mol/L; -2.1±0.9 vs. -4.5±0.6mV; P" @default.
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- W2595055509 date "2000-10-01" @default.
- W2595055509 modified "2023-09-24" @default.
- W2595055509 title "Impaired β-Adrenoceptor-Mediated Hyperpolarization in Resistance Arteries from Prehypertensive Shr" @default.
- W2595055509 doi "https://doi.org/10.1161/01.hyp.36.suppl_1.701-e" @default.
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