Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595114075> ?p ?o ?g. }
- W2595114075 endingPage "887" @default.
- W2595114075 startingPage "839" @default.
- W2595114075 abstract "Investigations in the last 10 years have revealed a new category of neurological diseases mediated by antibodies against cell surface and synaptic proteins. There are currently 16 such diseases all characterized by autoantibodies against neuronal proteins involved in synaptic signaling and plasticity. In clinical practice these findings have changed the diagnostic and treatment approach to potentially lethal, but now treatable, neurological and psychiatric syndromes previously considered idiopathic or not even suspected to be immune-mediated. Studies show that patients' antibodies can impair the surface dynamics of the target receptors eliminating them from synapses (e.g., NMDA receptor), block the function of the antigens without changing their synaptic density (e.g., GABAb receptor), interfere with synaptic protein-protein interactions (LGI1, Caspr2), alter synapse formation (e.g., neurexin-3α), or by unclear mechanisms associate to a new form of tauopathy (IgLON5). Here we first trace the process of discovery of these diseases, describing the triggers and symptoms related to each autoantigen, and then review in detail the structural and functional alterations caused by the autoantibodies with special emphasis in those (NMDA receptor, amphiphysin) that have been modeled in animals." @default.
- W2595114075 created "2017-03-23" @default.
- W2595114075 creator A5014342106 @default.
- W2595114075 creator A5060587778 @default.
- W2595114075 creator A5089086027 @default.
- W2595114075 date "2017-04-01" @default.
- W2595114075 modified "2023-10-15" @default.
- W2595114075 title "Autoantibodies to Synaptic Receptors and Neuronal Cell Surface Proteins in Autoimmune Diseases of the Central Nervous System" @default.
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