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- W2595126491 abstract "A simple, rapid and accurate high performance liquid chromatography method is described for simultaneous determination of bromhexine hydrochloride and salbutamol sulphate from active pharmaceutical ingredients. The separation of drug was achieved on Zorbax Eclipse C18 (250 x 4.6 mm i.d.) with 5 μ particle size column showed most favorable chromatographic pattern over the other columns. The mobile phase consisted of a mixture of buffer and acetonitrile (65:35 % ( v/v)). The buffer was mixtures of 0.1 % (v/v) tri-ethyl amine solution adjusted the pH 3.0 with ortho-phosphoric acid. The detection was carried out at wavelength 225 nm. The mixture of buffer of pH 3.0 and acetonitrile (65:35% v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze bromhexine hydrochloride from active pharmaceutical ingredients." @default.
- W2595126491 created "2017-03-23" @default.
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- W2595126491 date "2015-01-01" @default.
- W2595126491 modified "2023-09-22" @default.
- W2595126491 title "Simultaneous determination of bromhexine hydrochloride and salbutamol sulphate in pharmaceutical dosage by reverse phase high performance liquid chromatography" @default.
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