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- W25951830 abstract "Interleukin-1 (IL-1) stimulates prostaglandin E{sub 2} (PGE{sub 2}) production in human fibroblasts by stimulating arachidonic acid mobilization and cyclooxygenase synthesis. Phorbol ester (PMA) also stimulates PGE{sub 2} production suggesting a positive role for protein kinase C (PKC) activation in PGE{sub 2} synthesis. The PKC inhibitor, sphingosine, had little effect on PGE{sub 2} production. However, when sphingosine was added along with IL-1, or IL-1 was added to sphingosine pretreated cells, PGE{sub 2} production increased synergistically; structural analogs of sphingosine did not mimic this effect. In PKC-deficient cells, IL-1-mediated PGE{sub 2} production was enhanced to a similar degree as those treated with sphingosine suggesting that functional PKC is not required for, and may even down-modulate, IL-1-mediated PGE{sub 2} production. The effect of sphingosine on IL-1-stimulated PGE{sub 2} was rapid; a one minute incubation of cells with sphingosine followed by washing and the addition of IL-1 resulted in about 30% of the stimulatory effect observed when sphingosine and IL01 were present together for 24 hours. Together, these data indicate that sphingosine can profoundly affect IL-1-mediated PGE{sub 2} synthesis, that PMA and IL-1 appear to stimulate PGE{sub 2} synthesis via fundamentally different pathways and, that sphingosine may modulate the ability of IL-1 to stimulatemore » PGE{sub 2} production independent of its effects upon PKC activity.« less" @default.
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- W25951830 date "1991-03-11" @default.
- W25951830 modified "2023-09-24" @default.
- W25951830 title "Sphingosine synergistically enhances interleukin-1-mediated prostaglandin E sub 2 production" @default.
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