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- W2595191987 abstract "The ovarian reserve, represented by the growing (large primary to antral) and dormant (primordial) follicles, is the most important parameter to determine fertility. Anti-Mullerian hormone (AMH), produced by granulosa cells of growing follicles, is considered as one of the best non-invasive tool to assess ovarian reserve in women. The aim of the present study is to assess serum AMH levels as a biomarker of ovarian reserve, especially for primordial follicles, using exposure to 4-vinylcyclohexene diepoxide (VCD), an industrial ovotoxicant product, to manipulate follicle populations. Groups of CD-1 mice were injected with vehicle (DMSO/saline) or VCD (80-160 mg/kg/d) to induce dose-dependent depletion of primordial and small primary follicles (targets of VCD). Mice were sacrificed 21, 41 and 61 days after the first injection. Body and organ weights showed no toxicity of VCD. We observed a significant decrease of small follicles (primordial and small primary) in all VCD-treated groups at all times examined compared to controls (p<0.05). Growing follicles decrease significantly at 41d (secondary) and 61d (secondary and antral) in VCD-treated groups examined compared to controls (p<0.05). Circulating AMH of VCD-treated groups decreased significantly on days 41 and 61 relative to control groups (p<0.05). Ovarian protein levels of pro-AMH and the mature form also declined in VCD-treated mice (41d and 61d). Serum estradiol, another biomarker of ovarian reserve, was not significantly changed in VCD-treated mice relative to control mice at any time point (p>0.05). With all treatment groups combined, serum AMH levels were correlated with primordial follicle numbers (p<0.05), though this was not the case if only VCD-treated mice. Moreover significant correlations are observed between growing follicles and circulating AMH (p<0.05), improving over time, The partial loss of small follicles in treated groups induced a decrease in growing follicles, suggesting that fewer follicles are activated in order to preserve fertility in spite of loss of primordial follicles. Despite its limitations, AMH is a better biomarker of ovarian reserve than estradiol. Serum AMH measurement is a useful tool to assess ovarian reserve, but not to assess rapid changes in primordial follicle numbers, for example from the impact of ovotoxicants on the female reproductive system. (poster)" @default.
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- W2595191987 date "2009-07-01" @default.
- W2595191987 modified "2023-09-27" @default.
- W2595191987 title "Modulation of Ovarian Reserve Using 4-Vinylcyclohexene Di-Epoxide to Study Anti-Mullerian Hormone as a Biomarker of Follicle Populations." @default.
- W2595191987 doi "https://doi.org/10.1093/biolreprod/81.s1.643" @default.
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