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- W2595236416 abstract "Purpose of review Use of perioperative opioids for surgical pain management of children presents clinical challenges because of concerns of serious adverse effects including life-threatening respiratory depression. This is especially true for children with history of obstructive sleep apnea. This review will explore current knowledge of clinically relevant factors and genetic polymorphisms that affect opioid metabolism and postoperative outcomes in children. Recent findings Within the past several years, an increasing number of case reports have illustrated clinically important respiratory depression, anoxic brain injuries and even death among children receiving appropriate weight-based dosages of codeine and other opioids for analgesia at home setting particularly following tonsillectomy. Several national and international organizations have issued advisories on use of codeine in pediatrics, based on cytochrome P450 family 2 subfamily D type 6 (CYP2D6) pharmacogenetics. We have discussed the pros and cons of alternatives to codeine for pain management. Summary Although routine preoperative genotyping to identify children at risk and personalized opioid use for pediatric perioperative pain management is still a distant reality, current known implications of CYP2D6 pharmacogenetics on codeine use shows that pharmacogenetics has the potential to guide anesthesia providers on perioperative opioid selection and dosing to maximize efficacy and safety." @default.
- W2595236416 created "2017-03-23" @default.
- W2595236416 creator A5049649985 @default.
- W2595236416 creator A5062638610 @default.
- W2595236416 creator A5071252297 @default.
- W2595236416 date "2017-06-01" @default.
- W2595236416 modified "2023-10-07" @default.
- W2595236416 title "Codeine and opioid metabolism" @default.
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- W2595236416 doi "https://doi.org/10.1097/aco.0000000000000455" @default.
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- W2595236416 hasPublicationYear "2017" @default.
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