FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595241805> ?p ?o ?g. }

• W2595241805 abstract "3626 Background: The Oncotype DX Colon Cancer Recurrence Score (RS) has been clinically validated as an independent predictor of individual recurrence risk in stage II colon cancer patients following surgery. As a result, physicians have been ordering the Oncotype DX assay for stage II colon cancer patients since January 2010, yet no data exist on the assay’s impact on adjuvant treatment planning in clinical practice. We performed a survey to characterize the impact of the assay on adjuvant treatment recommendations in stage II colon cancer. Methods: U.S. medical oncologists (n=346) who ordered Oncotype DX for ≥3 patients with stage II colon cancer were contacted and asked to complete a web-based survey regarding the single most recent stage II colon cancer patient for whom the assay was ordered. The survey was developed through cognitive interviews with four medical oncologists, and the protocol was institutional review board approved. Results: We analyzed survey results from 116 eligible physicians. Physicians were more often in community (86%) than academic or other practices, and had a median of 14.5 years (range, 2-40) of practice experience. The median patient age was 62 years (range, 32–85). Most patients (81%) had T3 disease. Patients had ≤8, 9-11 and ≥12 nodes examined 3%, 13% and 84% of the time and 38% had comorbidities. Of the 76 patients tested for MMR/MSI, 13 (17%) were MMR-D or MSI-H and 46 (61%) were MMR-P or MSI-L; 17 (22%) unknown. Median RS was 20 (range, 1-77). Before obtaining the RS, chemotherapy was planned in 52 (45%) patients, observation in 40 (34%), and there was no recommendation in 24 (21%). For the 92 patients with pre-assay recommendations, recommended treatment changed after obtaining the RS for 27 patients (29%). Treatment intensity decreased for 18 (67%) and increased for 9 (33%) of 27 changed recommendations. A significant trend of decreasing treatment intensity with lower RS values was observed (p=.0035). Conclusions: These findings indicate that for stage II colon cancer patients, treatment recommendations were changed by RS results in 29% of patients. Use of the Oncotype DX assay may lead to reductions in treatment intensity, contributing to the assay’s cost effectiveness." @default.
• W2595241805 created "2017-03-23" @default.
• W2595241805 creator A5010044319 @default.
• W2595241805 creator A5017807808 @default.
• W2595241805 creator A5026458883 @default.
• W2595241805 creator A5038841214 @default.
• W2595241805 creator A5068614908 @default.
• W2595241805 creator A5074776719 @default.
• W2595241805 date "2012-05-20" @default.
• W2595241805 modified "2023-09-22" @default.
• W2595241805 title "Effect of the 12-gene colon cancer assay results on treatment recommendations in patients with stage II colon cancer." @default.
• W2595241805 cites W1954402484 @default.
• W2595241805 cites W1966481025 @default.
• W2595241805 cites W2012168848 @default.
• W2595241805 cites W2023755107 @default.
• W2595241805 cites W2029738571 @default.
• W2595241805 cites W2035843475 @default.
• W2595241805 cites W2064300359 @default.
• W2595241805 cites W2067493741 @default.
• W2595241805 cites W2083168840 @default.
• W2595241805 cites W2085039931 @default.
• W2595241805 cites W2093871448 @default.
• W2595241805 cites W2098916599 @default.
• W2595241805 cites W2100258195 @default.
• W2595241805 cites W2105915644 @default.
• W2595241805 cites W2108376581 @default.
• W2595241805 cites W2117034433 @default.
• W2595241805 cites W2121708973 @default.
• W2595241805 cites W2122754380 @default.
• W2595241805 cites W2124381835 @default.
• W2595241805 cites W2127951115 @default.
• W2595241805 cites W2154582208 @default.
• W2595241805 cites W2158257131 @default.
• W2595241805 cites W2162102504 @default.
• W2595241805 cites W2162746289 @default.
• W2595241805 cites W2163549507 @default.
• W2595241805 cites W2164132780 @default.
• W2595241805 cites W2167136380 @default.
• W2595241805 cites W2167177168 @default.
• W2595241805 cites W2168680994 @default.
• W2595241805 cites W2219176524 @default.
• W2595241805 cites W2332520832 @default.
• W2595241805 cites W242223401 @default.
• W2595241805 cites W2590628213 @default.
• W2595241805 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.3626" @default.
• W2595241805 hasPublicationYear "2012" @default.
• W2595241805 type Work @default.
• W2595241805 sameAs 2595241805 @default.
• W2595241805 citedByCount "0" @default.
• W2595241805 crossrefType "journal-article" @default.
• W2595241805 hasAuthorship W2595241805A5010044319 @default.
• W2595241805 hasAuthorship W2595241805A5017807808 @default.
• W2595241805 hasAuthorship W2595241805A5026458883 @default.
• W2595241805 hasAuthorship W2595241805A5038841214 @default.
• W2595241805 hasAuthorship W2595241805A5068614908 @default.
• W2595241805 hasAuthorship W2595241805A5074776719 @default.
• W2595241805 hasConcept C104317684 @default.
• W2595241805 hasConcept C121608353 @default.
• W2595241805 hasConcept C126322002 @default.
• W2595241805 hasConcept C143998085 @default.
• W2595241805 hasConcept C146357865 @default.
• W2595241805 hasConcept C151730666 @default.
• W2595241805 hasConcept C502942594 @default.
• W2595241805 hasConcept C526805850 @default.
• W2595241805 hasConcept C54355233 @default.
• W2595241805 hasConcept C71924100 @default.
• W2595241805 hasConcept C86803240 @default.
• W2595241805 hasConceptScore W2595241805C104317684 @default.
• W2595241805 hasConceptScore W2595241805C121608353 @default.
• W2595241805 hasConceptScore W2595241805C126322002 @default.
• W2595241805 hasConceptScore W2595241805C143998085 @default.
• W2595241805 hasConceptScore W2595241805C146357865 @default.
• W2595241805 hasConceptScore W2595241805C151730666 @default.
• W2595241805 hasConceptScore W2595241805C502942594 @default.
• W2595241805 hasConceptScore W2595241805C526805850 @default.
• W2595241805 hasConceptScore W2595241805C54355233 @default.
• W2595241805 hasConceptScore W2595241805C71924100 @default.
• W2595241805 hasConceptScore W2595241805C86803240 @default.
• W2595241805 hasLocation W25952418051 @default.
• W2595241805 hasOpenAccess W2595241805 @default.
• W2595241805 hasPrimaryLocation W25952418051 @default.
• W2595241805 hasRelatedWork W1499647115 @default.
• W2595241805 hasRelatedWork W2009137688 @default.
• W2595241805 hasRelatedWork W2087376532 @default.
• W2595241805 hasRelatedWork W2148623901 @default.
• W2595241805 hasRelatedWork W2320937253 @default.
• W2595241805 hasRelatedWork W2602667116 @default.
• W2595241805 hasRelatedWork W2739326967 @default.
• W2595241805 hasRelatedWork W2791350986 @default.
• W2595241805 hasRelatedWork W2890331057 @default.
• W2595241805 hasRelatedWork W2898501638 @default.
• W2595241805 hasRelatedWork W2900017322 @default.
• W2595241805 hasRelatedWork W2912778798 @default.
• W2595241805 hasRelatedWork W2947509154 @default.
• W2595241805 hasRelatedWork W2947613448 @default.
• W2595241805 hasRelatedWork W2948086565 @default.
• W2595241805 hasRelatedWork W2961657323 @default.
• W2595241805 hasRelatedWork W3009971353 @default.
• W2595241805 hasRelatedWork W3202099490 @default.
• W2595241805 hasRelatedWork W2188502928 @default.

• next