Matches in SemOpenAlex for { <https://semopenalex.org/work/W2595303973> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2595303973 abstract "8534 Background: In phase II trials, postoperative therapy with Canvaxin allogeneic melanoma cell vaccine plus Bacillus Calmette-Guerin (BCG) improved the survival of patients with stage IV melanoma. A multicenter, phase III placebo-controlled study was undertaken to investigate the vaccine’s efficacy. Methods: After complete resection of melanoma involving up to 5 distant sites, patients were randomized to treatment with BCG plus Canvaxin (BCG-Canvaxin) or BCG plus placebo (BCG-placebo). The primary endpoint was overall survival (OS); secondary endpoints were disease-free survival (DFS) and skin test responsiveness to the study agent. Results: Between May 1998 and April 2005, 496 patients were randomized. In April 2005, entry to the study was terminated due to low probability of demonstrating treatment differences. However, 256 patients from sites enrolled in a follow-up study were monitored until March 2010. Median OS and 5-year and 10-year rates of OS were 39.1 months, 43.3% and 33.3%, respectively, in the BCG-placebo group, versus 34.9 months, 42.5% and 36.4%, respectively, in the BCG-Canvaxin group (hazard ratio, 1.053; 95% confidence interval, 0.81 to 1.36; p=0.6964). Median DFS, 5-year DFS, and 10-year DFS were 7.6 months, 23.8% and 21.7%, respectively, for the BCG-placebo group, versus 8.5 months, 30.0%, and 30.0%, respectively, for the BCG-Canvaxin group (hazard ratio, 0.882; 95% confidence interval, 0.708 to 1.097; p=0.2595). Positive skin test results correlated with improved survival. Conclusions: BCG-Canvaxin was not superior to BCG-placebo, but the highly favorable long-term survival for combined groups indicates that complete metastasectomy should be considered as initial therapy for patients with resectable stage IV melanoma (ClinicalTrials.gov identifier: NCT00052156)." @default.
- W2595303973 created "2017-03-23" @default.
- W2595303973 creator A5005041126 @default.
- W2595303973 creator A5005836279 @default.
- W2595303973 creator A5009495362 @default.
- W2595303973 creator A5009506960 @default.
- W2595303973 creator A5012671311 @default.
- W2595303973 creator A5013352105 @default.
- W2595303973 creator A5021355934 @default.
- W2595303973 creator A5021447572 @default.
- W2595303973 creator A5023047936 @default.
- W2595303973 creator A5029428307 @default.
- W2595303973 creator A5035263718 @default.
- W2595303973 creator A5043543502 @default.
- W2595303973 creator A5049324725 @default.
- W2595303973 creator A5064210978 @default.
- W2595303973 creator A5067606220 @default.
- W2595303973 creator A5068690561 @default.
- W2595303973 creator A5073314254 @default.
- W2595303973 creator A5079717318 @default.
- W2595303973 creator A5080404941 @default.
- W2595303973 creator A5087832965 @default.
- W2595303973 date "2012-05-20" @default.
- W2595303973 modified "2023-09-22" @default.
- W2595303973 title "Long-term cure after complete resection and adjuvant immunotherapy for distant melanoma metastases." @default.
- W2595303973 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.8534" @default.
- W2595303973 hasPublicationYear "2012" @default.
- W2595303973 type Work @default.
- W2595303973 sameAs 2595303973 @default.
- W2595303973 citedByCount "1" @default.
- W2595303973 countsByYear W25953039732013 @default.
- W2595303973 crossrefType "journal-article" @default.
- W2595303973 hasAuthorship W2595303973A5005041126 @default.
- W2595303973 hasAuthorship W2595303973A5005836279 @default.
- W2595303973 hasAuthorship W2595303973A5009495362 @default.
- W2595303973 hasAuthorship W2595303973A5009506960 @default.
- W2595303973 hasAuthorship W2595303973A5012671311 @default.
- W2595303973 hasAuthorship W2595303973A5013352105 @default.
- W2595303973 hasAuthorship W2595303973A5021355934 @default.
- W2595303973 hasAuthorship W2595303973A5021447572 @default.
- W2595303973 hasAuthorship W2595303973A5023047936 @default.
- W2595303973 hasAuthorship W2595303973A5029428307 @default.
- W2595303973 hasAuthorship W2595303973A5035263718 @default.
- W2595303973 hasAuthorship W2595303973A5043543502 @default.
- W2595303973 hasAuthorship W2595303973A5049324725 @default.
- W2595303973 hasAuthorship W2595303973A5064210978 @default.
- W2595303973 hasAuthorship W2595303973A5067606220 @default.
- W2595303973 hasAuthorship W2595303973A5068690561 @default.
- W2595303973 hasAuthorship W2595303973A5073314254 @default.
- W2595303973 hasAuthorship W2595303973A5079717318 @default.
- W2595303973 hasAuthorship W2595303973A5080404941 @default.
- W2595303973 hasAuthorship W2595303973A5087832965 @default.
- W2595303973 hasConcept C121608353 @default.
- W2595303973 hasConcept C126322002 @default.
- W2595303973 hasConcept C141071460 @default.
- W2595303973 hasConcept C143998085 @default.
- W2595303973 hasConcept C159110652 @default.
- W2595303973 hasConcept C2777658100 @default.
- W2595303973 hasConcept C2777701055 @default.
- W2595303973 hasConcept C2777863537 @default.
- W2595303973 hasConcept C2779013556 @default.
- W2595303973 hasConcept C2994587330 @default.
- W2595303973 hasConcept C3019926457 @default.
- W2595303973 hasConcept C502942594 @default.
- W2595303973 hasConcept C71924100 @default.
- W2595303973 hasConceptScore W2595303973C121608353 @default.
- W2595303973 hasConceptScore W2595303973C126322002 @default.
- W2595303973 hasConceptScore W2595303973C141071460 @default.
- W2595303973 hasConceptScore W2595303973C143998085 @default.
- W2595303973 hasConceptScore W2595303973C159110652 @default.
- W2595303973 hasConceptScore W2595303973C2777658100 @default.
- W2595303973 hasConceptScore W2595303973C2777701055 @default.
- W2595303973 hasConceptScore W2595303973C2777863537 @default.
- W2595303973 hasConceptScore W2595303973C2779013556 @default.
- W2595303973 hasConceptScore W2595303973C2994587330 @default.
- W2595303973 hasConceptScore W2595303973C3019926457 @default.
- W2595303973 hasConceptScore W2595303973C502942594 @default.
- W2595303973 hasConceptScore W2595303973C71924100 @default.
- W2595303973 hasLocation W25953039731 @default.
- W2595303973 hasOpenAccess W2595303973 @default.
- W2595303973 hasPrimaryLocation W25953039731 @default.
- W2595303973 isParatext "false" @default.
- W2595303973 isRetracted "false" @default.
- W2595303973 magId "2595303973" @default.
- W2595303973 workType "article" @default.