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- W2595440107 abstract "611 Objectives To evaluate the diagnostic performance of Ga68-PSMA lignad PET/CT for initial staging in proven cases of prostatic carcinoma, possible correlation with various clinical parameters and its comparison with conventional imaging. Methods In this retrospective study, we evaluated the 50 consecutive patients (age range 50-88 years; mean age 68.02 years) of prostatic carcinoma for initial staging who underwent Ga68-PSMA ligand PET/CT. PET/CT reports were analyzed by two expert nuclear medicine physicians and any abnormal uptake on PET images were correlated with lesion on CECT and taken as positive. Histopathological examination, clinical and imaging or biochemical follow up were taken as reference standard. Prostate-specific antigen (PSA) level and Gleason score (GS) were evaluated in correlation with the PET results. Conventional anatomical images (USG / CT or MR scans) and FDG PET (if done) were also evaluated for comparison. Results Of the 50 biopsy proven patients for initial staging, primary disease was localized in 49 patients with an average SUVmax of 20.7 (4.2 -52.2) as compared to low background uptake (average SUV max 0.8). Regional metastases (pelvic lymph nodes) were detected in 35 patients while distant metastases were noted in 26 patients. The mean prostate-specific antigen (PSA) value was 51.22 ng/ml (range 0.31-204 ng/ml). PSA value had shown a significant correlation with the SUVmax of the primary lesion (P=0.022) and distant metastases (P=0.0406) but there was no correlation for detection of regional lymph nodes (P=0.3322). When correlated with GS, SUVmax in the primary lesion had no correlation (P=0. 2485) while there was significant correlation for detection of regional lymph nodes (P =0. 0026) and distant disease (P =0. 0084). PET detected more loco-regional metastatic disease than conventional imaging (USG, CT or MR) done in 15 patients and more skeletal lesions than bone scintigraphy (n=14). There was no correlation between PSMA PET and bone scan (P=0.1130) for detection of skeletal lesions. A patient based analysis of PSMA PET had shown sensitivity of 98% and 100% positive predictive value for detection of primary. Conclusions Ga68-PSMA ligand PET/CT is one stop diagnostic modality of choice for initial staging of prostatic carcinoma with high sensitivity and PPV in the localization of primary and detection of distant metastases helping in management strategy. Ga68-PSMA ligand PET examination identified a higher proportional loco-regional metastases than conventional imaging and better than bone scintigraphy for localization of skeletal metastases." @default.
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- W2595440107 date "2016-05-01" @default.
- W2595440107 modified "2023-09-26" @default.
- W2595440107 title "Ga68-labelled PSMA ligand PET/CT in the initial staging of biopsy proven prostatic carcinoma and comparison with conventional imaging" @default.
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